DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Ighmbp2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_113774.2	Gene:	Ighmbp2 / 29532	RGDID:	68325	Length:	988	Species:	Rattus norvegicus

Alignment Length:	709	Identity:	177/709 - (24%)
Similarity:	291/709 - (41%)	Gaps:	199/709 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1011 EIFVPLMKLELLSTIERDYKINNKNTFS--VSLINVETQDMC---------------YRLVTRVN 1058
            |.|| ..:|:||. :|||.::..:.::.  .||..::::.:|               .|||| ..
  Rat     7 ESFV-AQQLQLLE-LERDAEVEERRSWQEHSSLKELQSRGVCLLKLQVSGQRTGLYGQRLVT-FE 68

  Fly  1059 SKPFGKFVL-----YT------LY--------CCGMLKETFANLLELKFVSGNVFDL------TF 1098
            .:.||..|:     :|      ||        ..|:|.......:.:.|...:.|.|      |:
  Rat    69 PRKFGPAVVLPSNSFTSGDIVGLYDTNESSQLATGVLTRITQKSVIVAFDESHDFQLNLDRENTY 133

  Fly  1099 EILK--QDISEEKLK----NIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQTVNEV 1157
            .:||  .|::.::||    .:|:..:.|....:.|.||.        |:|      .|...:
  Rat   134 RLLKLANDVTYKRLKKALLTLKKYHSGPASSLIDVLLGG--------STP------SPATEI--- 181

  Fly  1158 SLPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNA 1222
                .|.||... .|:..|:..|....      .|..:.:|.|||||||:..:.|:.||
  Rat   182 ----PPLTFYNT-TLDPSQKEAVSFAL------AQKEVAIIHGPPGTGKTTTVVEIILQ------ 229

  Fly  1223 AKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAK 1287
            |.....|:|.||.||.|||::|..|....:       .:||.|...::....:..||:|...::
  Rat   230 AVKQGLKVLCCAPSNIAVDNLVERLALCKK-------QILRLGHPARLLESVQQHSLDAVLARS- 286

  Fly  1288 EQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKK------LQLISNQLS 1346
                     :||:|:.    |::.:|.|:..|...|        |.|.:|      ::|:..:|.
  Rat   287 ---------DNAQIVA----DIRRDIDQVFGKNKKT--------QDKREKSNFRNEIKLLRKELK 330

  Fly  1347 PPLTQREEFEISHMCVTRANIICTTLSSC-----VKLANYVDFFDICIVDEATQCTEPWTLLPMR 1406
                :|||..|. ..::.|:::..|.:..     :||.. .|:||:.:|||..|..|....:|:
  Rat   331 ----EREEAAIV-QSLSAADVVLATNTGASTDGPLKLLP-EDYFDVVVVDECAQALEASCWIPL- 388

  Fly  1407 FGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQY 1471
            ......:|.||.:|||...:|.||...|||.|:.:|:       .:|.|:     ..:..|:.||
  Rat   389 LKAPKCILAGDHKQLPPTTVSHKAALAGLSRSLMERL-------AEKHGA-----AVVRMLAVQY 441

  Fly  1472 RMHPEICRWPNQYFYEDQL-----------------INAECTARFASPLIPYCVINLKYTCDSNG 1519
            |||..|.||.::..|..||                 .:.|.|:      :|..:|      |:.|
  Rat   442 RMHQAITRWASEAMYHGQLTAHPSVAGHLLKDLPGVADTEETS------VPLLLI------DTAG 494

  Fly  1520 A--------QNKSISNNEEARFVAKLLTEMDKHMPS------KRFSYGLISPYQNQCYALSQVIP 1570
            .        .::|..|..|.|.|.       .|:.:      :.....:|:||..|...|.|.:.
  Rat   495 CGLLELEEEDSQSKGNPGEVRLVT-------LHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLS 552

  Fly  1571 S-HMNITPQTVDSYQGLEKDVIIISNART--RG-CGFLTNYQRLNVALTRPRR-CLVIC 1624
            : |..:..::||.:||.||:.:|::..|:  :| .|||...:|:|||:||.|| ..|||
  Rat   553 NKHPELEIKSVDGFQGREKEAVILTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVIC 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	69/267 (26%)
		AAA_19	1194..1251	CDD:289986	23/56 (41%)
		YtxH	<1293..1347	CDD:295162	13/59 (22%)
		AAA_12	1435..1626	CDD:289832	60/226 (27%)
Ighmbp2	NP_113774.2	TIGR00376	19..640	CDD:273041	171/695 (25%)
		SS DNA-binding. /evidence=ECO:0000250	637..783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..722
		R3H_Smubp-2_like	724..782	CDD:100070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..872
		Nuclear localization signal. /evidence=ECO:0000255	857..861
		ZnF_AN1	890..930	CDD:197545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810