DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Helz

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_008766536.1	Gene:	Helz / 287773	RGDID:	1307049	Length:	1981	Species:	Rattus norvegicus

Alignment Length:	786	Identity:	173/786 - (22%)
Similarity:	290/786 - (36%)	Gaps:	202/786 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   954 REWIRRENKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMK 1018
            |.| ...:|.:.|...:..:  .|....|....:...|:|.....:..:..:..||:.....|:.
  Rat   404 RRW-EPSSKTIVDFEPNETT--DWEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQSRLHDLLY 465

  Fly  1019 LELLSTIERDYKINNKNTFSVSL--------INVETQDMCYRLVTRV--------NSKPFGKFVL 1067
            :|.::..:...::|......|.:        :.|:.|.:...::|.|        |.:.||:|.|
  Rat   466 IEEIAQYKEVSRLNGIEPVKVPICVHCAKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKL 530

  Fly  1068 Y------TLYCCGMLKETFANLLEL------KFVSG-----NVFDLTFEILKQD-----ISEEKL 1110
            .      ||  .|.|..|..|.:.|      |.|..     .|::.|.|...:|     ||.|
  Rat   531 TETLSEDTL--AGRLVMTRVNAVYLLPVPKEKLVQSQGTKEKVYEATIEEKTKDYVFLRISRE-- 591

  Fly  1111 KNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCR------RILKPTQTVNEVSL-------PKQ 1162
             ..::|:.||..|: :|||     ..||...|||.      ||........::|:       |.:
  Rat   592 -CCEELSLRPDCDT-QVEL-----QFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNR 649

  Fly  1163 PFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLD 1227
            .:..:...:||..|:..||.....:...|.|  .||.||.||||:..:::.....|......
  Rat   650 QWDEQLDPRLNAKQKEAVLAITTPLCIQLPP--VLIIGPYGTGKTFTLAQAVKHILQQQETS--- 709

  Fly  1228 RKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQ 1292
             :||||.|||:|.|..:           :|..|    ...|..:..:||  |..:|.....:.:.
  Rat   710 -RILICTHSNSAADLYI-----------KDYLH----PYVEAGNAQARP--LRVYFRNRWVKTVH 756

  Fly  1293 RVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEI 1357
            .|..:.. ::...|                 ||:   |:.|||.
  Rat   757 PVVHQYC-LISSAH-----------------STF---QMPQKED--------------------- 779

  Fly  1358 SHMCVTRANIICTTLSSCVKLANYVD----FFDICIVDEATQCTEPWTLLPMRFGL--THMVLVG 1416
                :.:..::..||::...|.. :|    ||...::|||.|..|..|::|:....  |.:||.|
  Rat   780 ----ILKHRVVVVTLNTSQYLCQ-LDLEPGFFTHILLDEAAQAMECETIMPLALATKNTRIVLAG 839

  Fly  1417 DMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWP 1481
            |..||...|.|:.|.:..|..|:.||:....      |..:...    ..|...||.|..|..:.
  Rat   840 DHMQLSPFVYSEFARERNLHVSLLDRLYEHY------PAEFPCR----ILLCENYRSHEAIINYT 894

  Fly  1482 NQYFYEDQLI--NAECTARFASPLIPYCVINLKYTCDSNGAQNKSIS---NNEEARFVAKLLTEM 1541
            ::.|||.:|:  ..:...:...||       ..:|......|.|:.:   ||.|...|.:.:.|:
  Rat   895 SELFYEGKLMASGKQPAHKDFYPL-------TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEEL 952

  Fly  1542 DKHMP-----SKRFSYGLISPYQNQCYALSQVIP----SHMNITPQTVDSYQGLEKDVIIISNAR 1597
            .:..|     ....|.|:::||.:|.:.:...:.    |.:|:  :.|.:.||.:..|:.:|..|
  Rat   953 RRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNV--ERVLNVQGKQFRVLFLSTVR 1015

  Fly  1598 TR-GC-----------------------GFLTNYQRLNVALTRPRRCLVICGNFEDLKSV----E 1634
            || .|                       |||:||:.||.|:||.:..:.:.|:...|.|:    :
  Rat  1016 TRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRK 1080

  Fly  1635 MWRNLL 1640
            .|...:
  Rat  1081 FWERFI 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	61/262 (23%)
		AAA_19	1194..1251	CDD:289986	18/56 (32%)
		YtxH	<1293..1347	CDD:295162	8/53 (15%)
		AAA_12	1435..1626	CDD:289832	51/228 (22%)
Helz	XP_008766536.1	zf-CCCH	181..205	CDD:395517
		DEXXQc_HELZ	658..885	CDD:350835	69/306 (23%)
		SF1_C_Upf1	886..1086	CDD:350195	47/208 (23%)
		Atrophin-1	<1195..>1536	CDD:397323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810