DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Setx

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_006498142.1	Gene:	Setx / 269254	MGIID:	2443480	Length:	2701	Species:	Mus musculus

Alignment Length:	1987	Identity:	426/1987 - (21%)
Similarity:	707/1987 - (35%)	Gaps:	594/1987 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SREHANIIVSEKGVEVESLNPLNGLFINGGKLG-----------------DKINRLAVA-EGSTI 89
            ::|...|...:.|.|..|..|.|....||.:.|                 |.:.:::.: |..::
Mouse   700 AQEQVKISAEKSGKESSSYAPSNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSL 764

  Fly    90 SLGVTG--------VNLNEITG--IHAIFILKKKEPVVEEIVLSSDDDDTTPLPAVRCPTGTQP- 143
            ..|..|        :..:||..  .|.|....:|..:|:.|:   |.::.|.:..:...:||..
Mouse   765 KDGSVGKTSKPSFKLQKDEICAKLSHVIKKQIRKSTLVDNII---DLEENTAISDLENCSGTDGG 826

  Fly   144 --TEFNLKQQIPNFGGKQDPGQEE--------------EVLPSSSNLHLPKL------------- 179
              .|.::...:|:.....|..:|:              |.|.:||:....||
Mouse   827 ALKEDSIGHNVPSDPVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVS 891

  Fly   180 -TEVKQEIVKHTSEEIQNIFGEPSD-------AILNSVLE-------LNPYLYNK---LTNKTAN 226
             |||...:||...|....:..|..|       |:.::::|       ..|.:..:   |.|.|..
Mouse   892 FTEVTDTLVKAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLI 956

  Fly   227 NEIT------------RKKIHDGD--CI----------------------ELDTDTDRRSISE-- 253
            ::.|            ..::..||  |:                      |.|.|.|.||.||
Mouse   957 SQTTVIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEEN 1021

  Fly   254 ---------------AQKAEDPSAERE-VDDEEEYDESFAMSQAVIREMKAEMHVSDGEEDFLLT 302
                           ...|.:.|.|:: |.:||.|...|..|::.:.|.::...|....:|..:.
Mouse  1022 IKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVWQDHKID 1086

  Fly   303 NGMGNLPEGSPSNQAYDDIVYVSDSDDDEL--YDKVADWSKLLSQKVVPDVIEMSQTYPLENEHK 365
            :      :.|...:....:.:|:||.::.|  .|.|       |::||.:..|..:.:...:...
Mouse  1087 S------KNSLQGEQKSYVTHVADSTNNNLGCGDSV-------SEEVVRNKAEGVKEHAGPHSSV 1138

  Fly   366 DSDSDLDIGAKKPKRTLRISSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPDLP- 429
            .::.....|.|||||          ...|:|    |.:..:|..|....|.:..:.|.|..||.
Mouse  1139 SAEEFCKTGVKKPKR----------KRYDKV----TAEDPQRPSSSVGTDQLPDRRDLTESDLKS 1189

  Fly   430 -----AVRKLSVSSIDSVYENKQTKLNSKLKSCLKSPT-----KTSVDNMENMTETKSCSNRQRE 484
                 |....||.. ||....|.||..:..|...|.|.     ||..|.....::: ||
Mouse  1190 ADMGMATPSSSVER-DSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKS-SC------ 1246

  Fly   485 QIVASRNEPTNICPQKIETNKTSTRKRFVSTTSRDELSTTSK-EIKDAPKNNVEPPKKMLRSRSK 548
             .::.|..|..:.|:|:......|             ||..| .:|.||:...|     |..||.
Mouse  1247 -YISCRTSPAIVPPKKLRQCPEPT-------------STVEKLGLKKAPRKAFE-----LSQRSL 1292

  Fly   549 SCYIDRPVELDEH---ITKNEVPLKKKY-----ESVDNSKEELIVTLEAPAMLTTPTKS-KTQCV 604
            .|.    |:|.:|   :...:.|.|.|.     .|:.|:| :|:.:.:........::| |.:..
Mouse  1293 ECI----VQLRDHGKTVGVVDAPKKAKLISPQTLSIKNNK-KLLTSQDLQFQRLMRSRSHKKRDF 1352

  Fly   605 KKKATQTRGRRKTIHSRDEIRSLTAEAEENKKISPAKQTNE-----------EIPIPTKSPLKRN 658
            ..|.|.|....:.:...|.:.:.:.|.::::...|...:||           |:...:..|....
Mouse  1353 DYKNTDTVRVSRIVQGSDVLEADSDEPDDHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTG 1417

  Fly   659 AR-LLNRSKSCYM------DRLVISETEDPAK-----------KVIKDISPTKSDTTDNVLNFVD 705
            .. |:|:.:|..:      |.:::|.:|||..           ..:|...|..|..||:..|...
Mouse  1418 ITCLVNQCESRVLSGGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFL 1482

  Fly   706 VRQTRGPSVIEAPSLPKNRGKLRGVSAEVKVKDKVLDRQRFIDYQAEMNAKWKQKPKDKKKEDEK 770
            .:  ..|..::..|..:|:..:.....:...::..|.|.: ::..:....|:|...:..|.:.|
Mouse  1483 TQ--HDPQDMDLCSQLENKTIIVAHKKDTVQREDSLSRPQ-LESLSITKCKYKDCVETTKNQGE- 1543

  Fly   771 LKECRREALKK-----LSEKP-----KENSHRSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPAP 825
              .|.|.:..|     |..||     .....|.||.|..:.:|.....|      |:|.::....
Mouse  1544 --YCPRHSEAKAADDGLFRKPGLPLSVARPLRPTTTKIFSSSSASRTAN------LSKSLESTTL 1600

  Fly   826 KLAKTDNAKPPPKKPVPKQPPAIETFSQQLQAADKAVLHPQPQCSRPVERKEAELARNQRTCNKV 890
            :.:...| |....:|..|..|.....||                 :||       |..:..||
Mouse  1601 QQSALKN-KSSGAQPNLKVTPPSSMGSQ-----------------KPV-------AEVKSLCN-- 1638

  Fly   891 TFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERRE 955
                  ::|.:...|..                                |:..||..|
Mouse  1639 ------IFHFQTPSSSS--------------------------------KQSCKLTFS------- 1658

  Fly   956 WIRRENKPVN-----DIRQHSRSI--------LKWANQWL----KHGSVDAVAEQDVLMPIPPEF 1003
                ||:|.:     :|...|:||        |||..|..    |.|:..::. |.:..|:|..|
Mouse  1659 ----ENRPTSAASPVNILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLC-QSISRPVPVRF 1718

  Fly  1004 DSFKNYREIFVPLMKLELLSTIERDYKIN-NKNTFSVSLINVETQDMCYRLVTR---VNSKPFGK 1064
            .....|..:|:||:.|....|:.:::..: ||..|             |:|..|   .:.|.:.:
Mouse  1719 QDCAEYFNVFLPLIILNAFETVAQEWLSSPNKENF-------------YQLQLRKFPADYKKYWE 1770

  Fly  1065 FVLY-----------------------------------TLYCCGMLKETFANLLELKFVSGNVF 1094
            |::|                                   :.|.||.:.: |.....::  ||..
Mouse  1771 FLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDCSHYYCGYVHK-FRRTSVMR--SGKA- 1831

  Fly  1095 DLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRS-SPLCRRILKPTQTVNEVS 1158
            :.:..|..||.....:||   ||...|:.||......|.|:..|.| :.|.|.:|.|
Mouse  1832 ECSLCIQTQDTLPASVKN---LTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNP-------- 1885

  Fly  1159 LPKQPFTFKGCHK----------------LNEHQENIVLHTYQRIIDDLQPS---LTLIQGPPGT 1204
               .|..|  |.|                .||.|:..:...|..:  ...||   :.||.|||||
Mouse  1886 ---NPMDF--CTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMV--KHSPSVAKICLIHGPPGT 1943

  Fly  1205 GKSRVISELCLQTLYGNA----------AKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQ- 1258
            |||:.|..|..:.|..|.          ||....::|:||.||.|||.::..:....:...:|:
Mouse  1944 GKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKK 2008

  Fly  1259 --------FHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKE---NAEILKKQHNDL--- 1309
                    .:|:|.|..:.::.....|||::..|...::.|....:|   ..|||..|.::|
Mouse  2009 NPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQ 2073

  Fly  1310 --------KDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRAN 1366
                    :.:.|:|.|...:.|.. .|:|..|.|::|      ..|  ||.:..|    :..::
Mouse  2074 RALCRGGREMQRQELDEHIAIVSKE-RQELASKIKEVQ------GRP--QRAQNTI----ILESH 2125

  Fly  1367 IICTTLSSCVKLANYVDF-------FDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLPAV 1424
            :||.|||:...|.....|       |...|||||.|..|..||.|:......::||||.:|||..
Mouse  2126 VICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPT 2190

  Fly  1425 VLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQ 1489
            |:|.||.::|...||..|..:.|:..:::   ..:....:.:|:.||||||:||.:|:.|.|...
Mouse  2191 VISMKAQEYGYDQSMMARFCKLLEENVEQ---NMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKN 2252

  Fly  1490 L------INAECTARFASPLIPYCVINLKYTCDSNGAQ---NKSISNNEEARFV---AKLLTEMD 1542
            |      .:..|::.:  |..||.|.::     .:|::   |.|..|.:|.:.|   .||:.|..
Mouse  2253 LKTNRLTESIRCSSEW--PFQPYLVFDV-----GDGSERRDNDSYINVQEIKLVMEIIKLIKEKR 2310

  Fly  1543 KHMPSKRFSYGLISPYQNQCYALSQVI-----------PSHMNITPQ------------------ 1578
            |.:..:  :.|:|:.|:.|...:.:.:           |..|..:.|
Mouse  2311 KDISFR--NIGIITHYKAQKTMIQKDLEKEFDKKGLLQPIMMGESRQQDSEASKQQQKSSEFMHA 2373

  Fly  1579 ------------------------------TVDSYQGLEKDVIIISNARTR----GCGFLTNYQR 1609
                                          |||::||.:||.||::..|..    ..|||.:.||
Mouse  2374 SDELGSSTVTQSGISSLENGATHTGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQR 2438

  Fly  1610 LNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKR 1646
            |||.:||.:..|.|.|:...|...:.|..|:.||:||
Mouse  2439 LNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKR 2475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017	14/78 (18%)
		FHA	<10..101	CDD:224630	14/83 (17%)
		AAA_11	1171..1428	CDD:289831	85/315 (27%)
		AAA_19	1194..1251	CDD:289986	25/69 (36%)
		YtxH	<1293..1347	CDD:295162	15/67 (22%)
		AAA_12	1435..1626	CDD:289832	61/265 (23%)
Setx	XP_006498142.1	SEN1_N	37..>334	CDD:372274
		DEXXQc_SETX	1910..2235	CDD:350800	94/342 (27%)
		AAA_12	2201..2455	CDD:372468	61/265 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6656
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101455
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.760