DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and upf1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_593080.1	Gene:	upf1 / 2542327	PomBaseID:	SPAC16C9.06c	Length:	925	Species:	Schizosaccharomyces pombe

Alignment Length:	831	Identity:	207/831 - (24%)
Similarity:	340/831 - (40%)	Gaps:	232/831 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   939 RKECIKLRLSSYRERREWIRRENKPVNDIRQH--------------------SRSILKWANQWLK 983
            |:.|.:   :|..:...|...:.:|:...||.                    |:.:::....|.|
pombe   131 RQPCAR---ASIAKDMNWDLTQWQPIISDRQFLPWLITPPSEEEQKLAIPITSQQMVRLEELWRK 192

  Fly   984 HGS-----VDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLIN 1043
            ..:     :|...|.|.|..:...:.....|:.:..||::      .|.||....|.:
pombe   193 DPNANLEDLDKPIEDDSLPSVELRYKDAHAYQAVLSPLIQ------AEADYDKRLKES------- 244

  Fly  1044 VETQ-DMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFE-------- 1099
             :|| |:..|....:|.:....|:|..|           ...|::...|:...||:|
pombe   245 -QTQKDVVVRWDQAINKRYTAWFLLPKL-----------ESGEIRLAIGDEMKLTYEGELRAPWS 297

  Fly  1100 ----ILK--QDISEEKLKNIKQLTARPV----------------VDSLRVEL-------GALSA- 1134
                ::|  .::|:|....:|:....|:                .|.::..|       ..||:
pombe   298 STGYVIKIPNNVSDEVGLELKRSDKVPIECTHNFSVDYVWKSTSFDRMQTALRLFATDGSRLSSF 362

  Fly  1135 -VHQLRSSPLCRRILKPTQTVNEVSLPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLI 1198
             .|:|....:....||| :..:::|:|..|       |||..|...|     |.:  |...|:||
pombe   363 LYHKLLGHDIPPSFLKP-KLPSDLSVPNLP-------KLNASQSEAV-----RAV--LSKPLSLI 412

  Fly  1199 QGPPGTGKSRVISELC--LQTLYGNAAKTLDRKILICAHSNTAVD------HIVGLLGSVLRVMN 1255
            ||||||||:...:.:.  |.|:.....|: ...:|:||.||.|||      |..||  .|:||..
pombe   413 QGPPGTGKTVTSASVVYHLATMQSRKRKS-HSPVLVCAPSNVAVDQLAEKIHRTGL--RVVRVAA 474

  Fly  1256 RDQFHL---LRF-GMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQL 1316
            :.:..:   :.| .:||::.:|.        ||    .:|||:.|     |:.::|:|.
pombe   475 KSREDIESSVSFLSLHEQIKNYK--------FN----PELQRLLK-----LRSENNELS------ 516

  Fly  1317 KEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCV----- 1376
                           .|.||||::        |....|.|:    :..|::||.|   ||
pombe   517 ---------------IQDEKKLRI--------LVAAAEKEL----LRAAHVICCT---CVGAGDR 551

  Fly  1377 KLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFD 1441
            :::.|.  |...::|||||.:||..::|:..|...:|||||.|||..||::||.....||.|:|:
pombe   552 RISKYK--FRSVLIDEATQASEPECMIPLVLGAKQVVLVGDHQQLGPVVMNKKVALASLSQSLFE 614

  Fly  1442 RIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTA-RFA----- 1500
            |:              .::....|:|..||||||.:..:|:..|||..|.|...|: |.|
pombe   615 RL--------------IILGNSPFRLVVQYRMHPCLSEFPSNTFYEGTLQNGVTTSERIARHVDF 665

  Fly  1501 ------SPLIPYCVINLKYTCDSNGAQNKSISNNEEARFVAKLLTEM--DKHMPSKRFSYGLISP 1557
                  |||:.|.    .:..:...|...|..|..||....|::|..  ...:|.:   .|:::|
pombe   666 PWIQPDSPLMFYA----NFGQEELSASGTSFLNRTEASTCEKIVTTFLRSNVLPEQ---IGIVTP 723

  Fly  1558 YQNQCYALSQVIPS--------HMNITPQTVDSYQGLEKDVIIISNART---RGCGFLTNYQRLN 1611
            |..|...:.|.:.:        :..:...:||::||.|||.||:|..|:   :|.||:.:.:|||
pombe   724 YDGQRSYIVQYMQNNGSMQKDLYKAVEVASVDAFQGREKDFIILSCVRSSEHQGIGFVNDPRRLN 788

  Fly  1612 VALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFNLDRDDVNDLDR 1662
            |||||.:..:::.||.:.|....:|.:.:... |.|.|  |....:|.|.:
pombe   789 VALTRAKYGVIVLGNPKVLAKHALWYHFVLHC-KEKGY--LVEGTLNSLQK 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	83/273 (30%)
		AAA_19	1194..1251	CDD:289986	25/64 (39%)
		YtxH	<1293..1347	CDD:295162	10/53 (19%)
		AAA_12	1435..1626	CDD:289832	61/215 (28%)
upf1	NP_593080.1	UPF1_Zn_bind	44..193	CDD:286500	9/64 (14%)
		DNA2	66..839	CDD:224037	207/831 (25%)
		P-loop_NTPase	392..>597	CDD:304359	81/269 (30%)
		AAA_12	608..805	CDD:289832	63/217 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810