DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and cwf11

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_595360.1	Gene:	cwf11 / 2541124	PomBaseID:	SPBC646.02	Length:	1284	Species:	Schizosaccharomyces pombe

Alignment Length:	934	Identity:	174/934 - (18%)
Similarity:	301/934 - (32%)	Gaps:	359/934 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   909 QKKLRKVHFN--DDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHS 971
            :|...||.|.  .:|.::..:|.:    .|....|.|...|......|..:.:||...|.....:
pombe   362 EKYAIKVDFEFLKNVFINTYDRTR----LVNDYDEIINFTLKDVLGERSVMDQENSLTNYFLLQN 422

  Fly   972 RSILKWANQWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNT 1036
            .:|     |:|   |:.....|           ..|.|:::.:..:..|||:..|:..:::.||.
pombe   423 TAI-----QYL---SISFFMRQ-----------QSKAYKKLLLRSLYAELLNFSEQYRRLSIKNA 468

  Fly  1037 FSVSLINVETQDMCYRL----VTRVNSKPFGKFVLYTLYCCGM------------------LKET 1079
            ..    |: |:|..:.|    ||.|.....|: ||.....|.|                  :|..
pombe   469 TK----NL-TKDNFFSLNNFKVTSVAPPQIGQ-VLPQFVKCQMGLSRPGPFHSALRDLKNSIKSP 527

  Fly  1080 FANL------LELKFVSGN-------VFDLT-----------FEILKQDISEEKLKNI------- 1113
            |..|      :|.|.:.||       |.|.|           |:...|..|:.|..|:
pombe   528 FLCLIYISKDMEYKLLHGNALDPLEGVTDFTIATICNDDVGMFQSDMQSDSDNKSINVYLSPFYY 592

  Fly  1114 -----------KQ------LTARPVVDSLRVELGAL-SAVHQLRSSP--------------LC-- 1144
                       ||      |...|..:...::|..| |.:::.:..|              :|
pombe   593 HSLAGLGEYRPKQLKFNFALVLSPEANKYWLDLNILVSLLNRAKEFPKWFEDLFLGFGTPDICAF 657

  Fly  1145 ----------RRILKPTQTVNEVSLPKQPFTFKGCH------------KLNEHQENIV------- 1180
                      |.:....:.:..| ||       .||            |...:|..|.
pombe   658 PNAGLNSIYARNLFNTVEQLQSV-LP-------NCHVPSNLSTESLLIKFYTNQNKISADVTASD 714

  Fly  1181 ---------LHTY-----QRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKIL 1231
                     |:||     :.|:...||.||::.||...||..::.:| |:.|...:..  ||.::
pombe   715 RHFLLPSNRLYTYNDKQLESILRGSQPGLTMVNGPTRCGKHVLVCKL-LEVLQDTSPN--DRTVV 776

  Fly  1232 I------------------CAH-------SNTAVDHIV---GLLGS-------VLRVMNRDQFHL 1261
            :                  |.|       |:...|..:   |.|.|       :||.:.|....:
pombe   777 LSDSNFSMNTLFTLLEKARCFHQGHLLYLSDEGKDETLERYGTLSSWISKLPGLLREIGRLAASI 841

  Fly  1262 LRFGMH-----------------------------EKMSHYSRPFSLEAHFNKAKEQKLQRVSKE 1297
            ...|.|                             :.:..|:| |...::|....::.::..:|:
pombe   842 QAPGSHDASPDTALYFRDAYIKRLWEKYLNTVDDKDSVDAYNR-FPFHSYFGDKSKRPIETYNKD 905

  Fly  1298 N-AEILKKQHNDLKDEIQQLKE--KTNLTSTYLLQQLQ---QKEKKLQLISNQLSPPL-TQREE- 1354
            | .:...|.:.:|:...|||:|  ...|...|..|:|.   |:.:.:......||..| |.:|:
pombe   906 NFFDYATKLYGELEYMFQQLEEIRPFGLLRYYEDQELYALCQQSRIIGCTWTSLSTRLGTLKEKG 970

  Fly  1355 FEISHMCVTRANIICTTLSSCVKLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQ 1419
            |..:::.|..:..|..:..:.:.|:|               | ||       .|...:||:|: |
pombe   971 FCFNNLIVMNSQNISESSITSILLSN---------------C-EP-------TGFDRLVLLGN-Q 1011

  Fly  1420 QLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQY 1484
            .|.:   ..:.|:...:.|:|.|::              .:.:::..|:|||.:.
pombe  1012 YLTS---GNQDINNTSNGSLFKRLR--------------YLKSRIIDLNTQYNVR---------- 1049

  Fly  1485 FYEDQLINAECTARFASPLIPYCVINLKYTCDSNGAQNKSISNNEEARFVAKLLTEMDKHMPSKR 1549
                     |..:...|.:.|   :::| |.||:                           |:||
pombe  1050 ---------ESISSLCSSIYP---LDIK-TVDSS---------------------------PNKR 1074

  Fly  1550 FSYGLISPYQNQCYALS-QVIPSHMNITPQTVDSYQGLEKDVIIISNARTRG----CGFLTNYQR 1609
            ..||      |..:|.. |.|         .|.:::|.::...:....:..|    ...|..|.|
pombe  1075 LDYG------NSGFAHEVQFI---------NVGAFKGSQETEPVSGYKQNLGEAEYAVALFQYMR 1124

  Fly  1610 LNVALTRPRRCLVICGNFEDLKSV 1633
            :   |..|...:|||..:|...|:
pombe  1125 M---LGYPTNEIVICTLYESQVSL 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	68/349 (19%)
		AAA_19	1194..1251	CDD:289986	18/91 (20%)
		YtxH	<1293..1347	CDD:295162	14/59 (24%)
		AAA_12	1435..1626	CDD:289832	34/195 (17%)
cwf11	NP_595360.1	Aquarius_N	49..>526	CDD:293008	39/192 (20%)
		TIGR00376	<728..1153	CDD:273041	99/531 (19%)
		UvrD_C_2	1027..1193	CDD:304668	36/201 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910