Protein Alignment CG7504 and SPBC29A10.10c

DIOPT Version :9

• Sequence 1: NP_001137907.1
• Gene: CG7504 / 38904
• FlyBaseID: FBgn0035842
• Length: 1676
• Species: Drosophila melanogaster
• Sequence 2: NP_596055.1
• Gene: SPBC29A10.10c / 2540523
• PomBaseID: SPBC29A10.10c
• Length: 1944
• Species: Schizosaccharomyces pombe
• Alignment Length: 1844
• Identity: 411/1844 - (22%)
• Similarity: 705/1844 - (38%)
• Gaps: 503/1844 - (27%)

  Fly   111 KKKEPVVEEIVLSSDDDDTTPLPAVRCPTGT-QPTEFN-----LKQQIPNFGGKQDPGQEEEV-- 167
            |...|.|..::.|.||:......::.....| ...||.     |.|:|.:...|::...|.::
pombe   186 KNLVPGVISLLFSRDDELRRWACSILSDVKTISDNEFKILEGPLLQEIRSLDQKKENENEMQIFL 250

  Fly   168 ------LPSSSNLHLPKLT----EVKQEIVKHTSEEIQNIFGEPSDAI-LNSVLELNPYLY--NK 219
                  |....:|:...||    .|...|:.....:..|:.  ||..: |:|:|    |.|  |.
pombe   251 KGLSLLLKHVDHLYFRGLTGKNFNVADFILSGLQSDHTNLC--PSFLVCLHSLL----YCYGRNF 309

  Fly   220 LTNKTANNEITRKKIHDGDCIELDTDTDRRSISEAQKAEDPSAEREVDDEEEYDESFAMSQAVIR 284
            .|.:.:.:|:. .||.:|:..:..|:.:..:.|..||||:|.         |:..|...:.::|.
pombe   310 WTPEISPSEVI-DKIFNGNAYKRWTEENTSNFSNDQKAENPF---------EWATSLLKTISIID 364

  Fly   285 EM--------------KAEMHVSDGEEDFLLTNGMGNLPEGSPSNQAYDDIVYVSDSDDDELYDK 335
            |:              |.|:.|  |.::..|...:.::     .:..:.:...:....|..|.:|
pombe   365 EVELINKILINYTMQYKKELEV--GFKNVQLLQSLADI-----FSVLFSEYFMIFPHSDQSLQNK 422

  Fly   336 VADWSKLLSQKVVPDVIEMSQTYPLENEHK----------DSDSDLDIGAKKP----------KR 380
            |.:....|:.|    ..|:.:...||||..          :...:||:...|.          |.
pombe   423 VFELHSTLAIK----FDELFRLLNLENEESVEWRLIKKVFEYRLNLDLYILKQFYCHYLDRNRKP 483

  Fly   381 TLRISSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPDLPAVRKLSVSSIDSVYEN 445
            .|.|.|.|:......|.:....:     :.|.....:|.:|.||           |..||.:...
pombe   484 PLNIKSVSESFKNFWVYLQNVFR-----EEKFFMVRIVFRACST-----------VCLIDKLPPK 532

  Fly   446 KQTKLNSKLKSCLKSPTKTSVDN---------MENMTETKSCSNRQREQIVASRNEPTNICPQKI 501
            |           :..|.|:..:|         .|.:.:|:......:.|:|
pombe   533 K-----------VDIPFKSDFENALNGFVATFSEMLIQTQCWHLSAQTQLV-------------- 572

  Fly   502 ETNKTSTRKRF---------VSTTSRDELSTTSKEIKDAPKNNVEPPKKMLRSR-----SKSCYI 552
             :|..:.|..|         :||.|...:.:.|  :.|:.   |:...::|||:     :.|||:
pombe   573 -SNPLTFRGIFSLVFSPILEISTGSISIIKSIS--LSDSV---VDTIGELLRSQFSNTLNSSCYV 631

  Fly   553 ------DRPVELDEHITK-NEVPLKKKYESVDNSKEELIVTLEAPAMLTTPTKSKTQCVKKKAT- 609
                  .|.....:||.. |::.:...::|||.              ||:...:..:.|:||.:
pombe   632 LLQWLKVRNFGGAKHIVYFNKLIINTIFDSVDG--------------LTSKDATFAKQVEKKESL 682

  Fly   610 ----QTRGRRKT----------IHSRDEIRSLTAE----------------------AEENKKIS 638
                ::..:..|          :|.:|.:..|..:                      ::.:.||.
pombe   683 KNFWESLWKFFTHFFIVLPTWPVHDKDNLVDLMRDTLDFCDMLINIFEEVNGFIFGLSDNDIKIV 747

  Fly   639 PAKQTNEEIPIPTKSPLKRNARLLNRSKSCYMDRLV---------ISETEDPAKKVIKDISPTKS 694
            .|......:.:.....|...:..|..:.|..:..:|         ..:.|.|..:.:.||....|
pombe   748 SANDKGSALAMCIADSLVTVSYWLKLTDSSLLTSVVKVICKMLKICKKLECPISQNVIDIIHRAS 812

  Fly   695 DTTD--NVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGVSAEVKVKDKVLDRQRFIDYQAEMNAKW 757
            .|:|  .:|.|.:                  |..| .:|....:.:.||:...|.|... :..|.
pombe   813 ITSDEQTILTFTE------------------REDL-FISLTPYLSEDVLNHSPFNDTNT-LETKL 857

  Fly   758 KQKPKDKKKEDE------KLKECR----------------REALKKLSEKPKE----NSHRSTTN 796
            :...:....:|:      ||.|..                .:|:.:.::|.:.    .|.:.||.
pombe   858 QSDDRGLLSKDQTIGIAKKLPESNISTSNHFLLPPKAISASKAINRNAQKSQNLNFLKSKQETTQ 922

  Fly   797 KRKNPTSVPTVQNTNRGGFLTKGV--DGPAPK-LAKTDNAKPPPKKPVPKQPPAIETFSQQLQAA 858
            :.:....||   .|:.|..|::.:  |...|| |.|.|:| .|.:||
pombe   923 RIRESAKVP---RTSAGNHLSEKLNSDNHIPKALQKLDSA-DPIRKP------------------ 965

  Fly   859 DKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEME-----LYHQKAEDSKKLQKKL---RKV 915
              ::||.....|.|.:       :|..|.::.|....|     |:....|.:....|.|   |::
pombe   966 --SLLHTSKSYSNPDD-------KNTSTSDEDTSESEEESSNGLFSLAREANSHASKSLPQRRQI 1021

  Fly   916 HF--NDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWA 978
            .|  .|.:|...:..........|...:..:|||:.                |:::..:.||.|
pombe  1022 QFLDFDSLKTKNVVHPTQLRRNTQQSAQLARLRLNP----------------DVQEFYKVILGW- 1069

  Fly   979 NQWLKHGSVDAVAEQDVLMP-IPPEF---DSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSV 1039
                 :...|:.:..:|.|. :..:|   || ..|.::|.|::..|..:.::.  .:..|....:
pombe  1070 -----NPLADSFSASNVEMQCVQAKFTYNDS-NAYEKVFKPMLFHECWAQVKS--AVEEKQYPPI 1126

  Fly  1040 SLINVETQDMCYRLVTRVNSKPFGKFV-LYTLYC----CGMLKETFANLLELKFVSGNVFD-LTF 1098
            .||          |.||   .....|| :|...|    ...|.:|...||.....||:..: .:|
pombe  1127 DLI----------LNTR---STVDNFVDIYFTSCSPTEVSFLSDTDICLLSKSQSSGDTNNPKSF 1178

  Fly  1099 EILK-QDISEEK-------LKNIKQLTARPVVDSLR----------VELGALSAVHQLRSSPLCR 1145
            ::.| |.||.:|       ..||:.:..:....::|          ..|...:|:..||..||.:
pombe  1179 QLCKIQSISRKKESLELCLRMNIESIDLQEYAPNIRFTAQKLFNATTSLREFAALKSLRHLPLSQ 1243

  Fly  1146 RILKPTQTVNEVSLPKQPFTFKGCHKL------NEHQENIVLHTYQRIIDDLQPSLTLIQGPPGT 1204
            |||    ..|...||.. ||.....|:      ||.|...:   |...::|   ..|||||||||
pombe  1244 RIL----DANVTRLPSN-FTDDKKQKIMKSYGVNEPQAYAI---YASSVND---GFTLIQGPPGT 1297

  Fly  1205 GKSRVI----------SELCLQ-TLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQ 1258
            ||::.|          |...|| .:.|...||...||||||.||.|:|.|      :||:.....
pombe  1298 GKTKTILGMIGAVLTSSSQGLQFNVPGQTRKTSKNKILICAPSNAAIDEI------LLRIKAGVY 1356

  Fly  1259 FH--------LLRFGMHEKMSHYSRPFSLEAHF-------NKAKEQKLQRVS---KENAEILKKQ 1305
            .|        ::|.|..:.:|.:::.|:||...       |..|:|:....|   |:...|:||:
pombe  1357 DHEGIKFFPKVIRVGFGDSISVHAKEFTLEEQMIKQMELTNLKKDQEANNSSDTRKKYDSIIKKR 1421

  Fly  1306 HNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQRE----------EFEISHM 1360
             :.|::::::.: .|...|:.|..||::..|:..::...|. .:.:|:          :.:|.:.
pombe  1422 -DSLREDLEKFR-STGKNSSILEAQLREITKQKNMLEQSLD-DMRERQRSTNRNLDVLKKQIQNQ 1483

  Fly  1361 CVTRANIICTTLSSC--VKLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLPA 1423
            .:..|:|:|.|||:.  ..|.|....|...|:|||.|..|..:::|:::|....|:|||..|||.
pombe  1484 LLQEADIVCATLSASGHELLLNAGLTFRTVIIDEAAQAVELSSIIPLKYGCESCVMVGDPNQLPP 1548

  Fly  1424 VVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFK--------LSTQYRMHPEICRW 1480
            .||||.:..||.|.|::                     .::||        ||.||||:|||.|:
pombe  1549 TVLSKTSAKFGYSQSLY---------------------VRMFKQHNESACLLSIQYRMNPEISRF 1592

  Fly  1481 PNQYFYEDQLINAECTARFAS-------PLIPYCVINLKYT-CDSNGAQNKSISNNEEARFVAKL 1537
            |:::||..:|::....:...|       .|..|...|:..| ..||   :||:.|.|||.|:..|
pombe  1593 PSKFFYNSKLLDGPNMSAVTSRPWHEDPQLGIYRFFNVHGTEAFSN---SKSLYNVEEASFILLL 1654

  Fly  1538 LTEMDKHMPSKRF--SYGLISPYQNQCYAL--------SQVIPSHMNITPQTVDSYQGLEKDVII 1592
            ...:.:...:..|  ..|:::||::|...|        ..:|..|::|  .|||.:||.|||:||
pombe  1655 YERLIQCYLNIDFEGKIGVVTPYRSQVQQLRSQFQRKYGSIIFKHLDI--HTVDGFQGQEKDIII 1717

  Fly  1593 ISNARTR---GCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFNLDR 1654
            .|..|:.   |.|||.:.:||||||||.:..|.|.||.:.|...:::.:|::||:.|.|:.:|..
pombe  1718 FSCVRSSMSGGIGFLQDLRRLNVALTRAKSSLYIVGNSKPLMQEDIFYSLIEDAKTRGVWRDLSA 1782

  Fly  1655 DDVNDLDRSLIK---KMMVNTINL 1675
            :...: .:|:..   .:..|.:||
pombe  1783 NQFKN-SKSISNVSTHLASNNLNL 1805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	88/303 (29%)
		AAA_19	1194..1251	CDD:289986	29/67 (43%)
		YtxH	<1293..1347	CDD:295162	13/56 (23%)
		AAA_12	1435..1626	CDD:289832	68/219 (31%)
SPBC29A10.10c	NP_596055.1	SEN1_N	75..784	CDD:289496	123/685 (18%)
		AAA_11	1270..1553	CDD:289831	87/297 (29%)
		AAA_19	1277..1355	CDD:289986	33/89 (37%)
		AAA_12	1560..1756	CDD:289832	70/221 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	96	1.000	Domainoid score	I1915
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101455
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.770