DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and dna2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_596499.2	Gene:	dna2 / 2540148	PomBaseID:	SPBC16D10.04c	Length:	1397	Species:	Schizosaccharomyces pombe

Alignment Length:	1633	Identity:	323/1633 - (19%)
Similarity:	570/1633 - (34%)	Gaps:	504/1633 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 ILN--SVLELNPYLYNKLTNKTANNEITRKKIHDGDCIELDTDTDRRSISEAQKAEDP--SAERE 265
            :||  :.|:|..:.||      |:.||:..||.:.....|.... :.:.:|:..:..|  .|.:|
pombe    39 LLNGRTKLKLENFAYN------ASTEISSPKISEKKHSSLPIKR-KNTFNESSTSFSPFTKAHKE 96

  Fly   266 VDDEEEYDESFAMSQAVIREMKAEMHVSD-------GEEDFLLTNGMGNLPEGSPSNQAYDDIVY 323
            :.|:.:.|:||.        .|::::..|       ..:|...::...:|.:...::....|:..
pombe    97 ITDDLKPDKSFT--------RKSDLNSQDMPVCFQETSKDLCRSSSTQHLLDHQTTDSTIIDMKP 153

  Fly   324 VSDSDDDELYDKVADWSKLLSQKVVPDVIEMSQTYPLENEHKDSDSDLDIGAKKPKRTLRISSSS 388
            ||.:...:::....|.:.||.:..       |...||.|.:..|.:            :..:.|.
pombe   154 VSTNSKSDVFTLYTDETVLLRRCA-------SDNKPLINNNLSSSN------------VSENQSR 199

  Fly   389 DEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPDLPAVRKLSVSSIDSVYENKQTKLNSK 453
            ...|.|||            |::..|.|.|       |.|       ||.|.:...::|:::.:.
pombe   200 SFGSYDEV------------KNQGNNLHKV-------PSL-------VSIIRNARSSEQSRIAAN 238

  Fly   454 LKSCLKSPTKTSVDNMENMTETKSCS-----NRQREQIVASRNEPTNICPQKIETNKTSTRKRFV 513
             .|||...:.|.:|..:...|.:..:     .||..|:      |.:......:..:.:.:...|
pombe   239 -SSCLLKGSDTEIDEDDFALEAEDLAALDSLERQYSQL------PNSTVTASAKDIEKTAKVNHV 296

  Fly   514 STTSRDELSTTSKEIKDAPKNNVEPPKKMLRSRSKSC---------YID---------RPVELDE 560
            ....:...|.|  :..||..|. ||....|   .|:|         :||         .|.||.|
pombe   297 GGDLQSYCSAT--KASDATINE-EPVNLAL---DKACNSLPDINSDFIDDWDDSCDGCTPGELCE 355

  Fly   561 HITKNEVPLKKKYESV----DNSKEELIVTLEAPAMLTTPTKSKTQCVKKKATQTRGRRKTIHSR 621
            .  .:|..:.:.:|..    .|...:|.:.|||..:|      ....::...|:|     :|...
pombe   356 F--SSEYTVLEVHEDFIFHEGNHFRQLKLILEANDIL------HQLFLRGDWTET-----SIFVG 407

  Fly   622 DEIRSLTAEAEENKKISPAKQTNEEIPIPTKSPLKRNARLLNRSKSCYM--DRLVISETEDPA-- 682
            |.||   .||..:|.                     |..:::..|...:  .::::|.|...:
pombe   408 DSIR---VEATFDKD---------------------NTAIVDNDKGLIIIHPKILMSATAVASSF 448

  Fly   683 ----KKVIKDI-----SPTKSDTTDNVL-NFVDVRQTRGPSVIEAPSLPKNRGKLRGVSAEVKVK 737
                |.||.|.     .|||:..|.|:| :|......||...:|...          ::.|..:|
pombe   449 PCLRKAVISDRVGIYGPPTKAMVTGNILHDFFQHALYRGIDALENVD----------INLETSIK 503

  Fly   738 DKVLDRQRFIDYQAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEK---PKENSHRSTTNKRK 799
            ..:.|     .|.|:::.       |:.:|:   .:.|...||.:.|:   .|:|
pombe   504 TYISD-----IYFADLSL-------DEIREE---LDARLPLLKSIVERYLISKKN---------- 543

  Fly   800 NPTSVPTVQNTNRGGFLTKGVDGP----APKLAKTDNAKPPPKKPVPKQPPAIETFSQQLQAADK 860
                    .|.|....:::.:|..    :|:.....|                      :.|..:
pombe   544 --------DNNNESIHISRLLDIEESIWSPRFGLKGN----------------------IDATVE 578

  Fly   861 AVLHPQPQCSR----PVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDV 921
            .||..:|:.|.    |:|.|......|..     .||:..||.....|         :...|.:.
pombe   579 VVLTEKPESSSTLTLPLELKTGRYVDNIS-----HFAQSLLYTLLISD---------RYGINTNQ 629

  Fly   922 KVHC------IERVKGASSKVQG-----------------------RKECIKLRLSSYRERREWI 957
            .:.|      |:.:..::|:::|                       ||.|....|.|  |...:.
pombe   630 ALLCYLENSTIKNLVASNSQLRGLIMTRNSLAQHNFRRSLPEMISNRKICDHCSLVS--ECLFFQ 692

  Fly   958 RRENKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELL 1022
            :..:|.|    .:|..:.:..|:|::.     |.::|  :....:::...|..|..:.|.:.::|
pombe   693 KMSDKGV----ANSNGLTESWNEWMRE-----VKDED--LEFYKKWEKLLNQEERLLLLKRGDVL 746

  Fly  1023 STIERDYKINNKNTFSVSLINVETQDMCYRLVTRV--------NSKPFGKFVLYTLYCCGMLKET 1079
            :....:.:...|..:.:.:...:.  :|..:..||        |...:.:..|::.:..|
pombe   747 TFDTEELEAYGKTLYPLYITKEDI--VCLEIDDRVFHYKFAFLNDNGYPRNFLHSGFSVG----- 804

  Fly  1080 FANLLELKFVS----------GNVFDL---------------------TFEILKQDI-----SEE 1108
                 |..|:|          |::..:                     .|:..|..:     .:.
pombe   805 -----ERVFISDEHGHWSLAKGHIVHIQDSCIEVRTRHRLHIPWLKMPNFDFKKNQVFFGNYEDS 864

  Fly  1109 KLKNIKQLTARPVVDSLRVELGALSAVHQLRSS-----PLCRR----ILKPTQTVNEVSLPKQPF 1164
            ||..|.....|..:|......|..|....|.||     ||..|    .|||.:..|...:..:
pombe   865 KLSFIGSNHTRYRIDKDEFSSGIASIRGTLMSSVLPDAPLIIRDMIIRLKPPKFCNSALIDPE-- 927

  Fly  1165 TFKGCHKLNEHQENIV--LHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLD 1227
             |..|  |||.|...:  .|..:.        .:||.|.|||||:..||.|....|    ||  .
pombe   928 -FLKC--LNEDQITALKKCHAAEH--------YSLILGMPGTGKTTTISSLIRSLL----AK--K 975

  Fly  1228 RKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQ 1292
            :|||:.:.::.|||:|      ::::...|. .::|.|...|:....:.|.|
pombe   976 KKILLTSFTHLAVDNI------LIKLKGCDS-TIVRLGSPHKIHPLVKEFCL------------- 1020

  Fly  1293 RVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEI 1357
                        ......|::..||
pombe  1021 ------------TEGTTFDDLASLK---------------------------------------- 1033

  Fly  1358 SHMCVTRANIICTTLSSCVKLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLP 1422
             |.......:.|::|.....:.|... ||.||:|||:|...|..|.|::.. ...|||||..|||
pombe  1034 -HFYEDPQIVACSSLGVYHSIFNKRK-FDYCIIDEASQIPLPICLGPLQLA-EKFVLVGDHYQLP 1095

  Fly  1423 AVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTK-LFKLSTQYRMHPEICRWPNQYFY 1486
            .:|.:.:....|||.|:|..:...              |.: :..|..||||:.:|....::..|
pombe  1096 PLVKNSRTSKDGLSLSLFKLLSEK--------------HPEAVTTLRLQYRMNEDINSLSSELIY 1146

  Fly  1487 EDQLINAECTARFASPLIPYC------------------VINLKY------TCDSNGAQNKS--- 1524
            ...|:....|......::|..                  :||..:      |.|..|.::|:
pombe  1147 GGNLVCGSKTISQKKLILPKAHLSDGLPDSSSSLHWVNKLINPSHSVIFFNTDDILGVESKTNNI 1211

  Fly  1525 ISNNEEARFVAKLLTE-MDKHMPSKRFSYGLISPYQNQCYALSQVIPSHMNITPQTVDSYQGLEK 1588
            :.|:.||..:.:.::. :::.:  |:.|.|:||.|::|...||:.:.|...|...|||.|||.:|
pombe  1212 LENHTEAFLIEQAVSSFLERGV--KQSSIGIISIYKSQVELLSKNLKSFTEIEINTVDRYQGRDK 1274

  Fly  1589 DVIIISNARTRGCG----FLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVY 1649
            |:|:||..|:....    .|.::.||||||:|.:...::.|:...|.|..:..:||....|.|..
pombe  1275 DIILISFVRSNSKNLVGELLRDWHRLNVALSRAKVKCIMFGSLSTLSSSNIVSHLLKLLEKNKWI 1339

  Fly  1650 FNLDRDDV 1657
            |.|:.:|:
pombe  1340 FTLNENDI 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	59/258 (23%)
		AAA_19	1194..1251	CDD:289986	21/56 (38%)
		YtxH	<1293..1347	CDD:295162	3/53 (6%)
		AAA_12	1435..1626	CDD:289832	55/223 (25%)
dna2	NP_596499.2	Dna2	385..579	CDD:285859	49/293 (17%)
		DNA2	444..1352	CDD:224037	225/1118 (20%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<558..689	CDD:294426	27/168 (16%)
		P-loop_NTPase	932..>1096	CDD:304359	57/252 (23%)
		AAA_12	1118..1316	CDD:289832	51/213 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810