DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7504 and SETX

DIOPT Version :9

Sequence 1:NP_001137907.1 Gene:CG7504 / 38904 FlyBaseID:FBgn0035842 Length:1676 Species:Drosophila melanogaster
Sequence 2:NP_001338457.1 Gene:SETX / 23064 HGNCID:445 Length:2706 Species:Homo sapiens


Alignment Length:1949 Identity:419/1949 - (21%)
Similarity:692/1949 - (35%) Gaps:637/1949 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 IVLSS---DDDDTTPLPAVRCPTGTQPTEFNLKQQ-IPNFGGKQDPGQEEEVLPSSSNLHLPKLT 180
            |::|:   .|..|..|..|    .|...:|:||.. :.....::...|::|:....|  |:.|..
Human   740 IIVSTRLLTDSSTDALEKV----STSNEDFSLKDDALAKTSKRKTKVQKDEICAKLS--HVIKKQ 798

  Fly   181 EVKQEIVKHTSEEIQNIFGEPSDAILNSVLELNPYLYNKLTNKTANNEITRKKIHDGDCIELDTD 245
            ..|..:|.:|....:|:          :|..:..:...|.|.           :..||....:..
Human   799 HRKSTLVDNTINLDENL----------TVSNIESFYSRKDTG-----------VQKGDGFIHNLS 842

  Fly   246 TDRRSISEAQKAEDPS------AEREVDDEEEYDESFAMSQAVIREMKAEMHVSDGEEDFLLTNG 304
            .|...:.:.:..|..|      .|:::.:||....||..:...|:    |.|| ||:|....|. 
Human   843 LDPSGVLDDKNGEQKSQNNVLPKEKQLKNEELVIFSFHENNCKIQ----EFHV-DGKELIPFTE- 901

  Fly   305 MGNLPEGSPSNQAYDDIVYVSDSDDDELYDKVADWSKLLSQKVVPDVIEMSQ------------- 356
            |.|..|...|  .:.|::.|.:|.|:|:.:..:.....|:::..||:...|.             
Human   902 MTNASEKKSS--PFKDLMTVPESRDEEMSNSTSVIYSNLTREQAPDISPKSDTLTDSQIDRDLHK 964

  Fly   357 ----------TYPLENEHKDSDSDLDIGAKKPKR-----------TLR----ISSSSDEDSADEV 396
                      |:|  ::...:.|.|....|:.||           |.|    |.|.||:|..:.:
Human   965 LSLLAQASVITFP--SDSPQNSSQLQRKVKEDKRCFTANQNNVGDTSRGQVIIISDSDDDDDERI 1027

  Fly   397 IVHQ--TKQKGRRSKSKSPNDHV--VRQADSTTP---------------DLPAVRKLSVSSIDSV 442
            :..:  |||.....:.:.|..||  |...:...|               |.......|.|.:.||
Human  1028 LSLEKLTKQDKICLEREHPEQHVSTVNSKEEKNPVKEEKTETLFQFEESDSQCFEFESSSEVFSV 1092

  Fly   443 YENKQTKLNSKL---KSCL----------------KSPTKTSVDNMENMTETKSCS--------- 479
            :::.....||..   |.||                ....|...:.:|..|..:|.|         
Human  1093 WQDHPDDNNSVQDGEKKCLAPIANTTNGQGCTDYVSEVVKKGAEGIEEHTRPRSISVEEFCEIEV 1157

  Fly   480 ----NRQREQIVAS---------RNEPTNICPQKIETNK--------------TST------RKR 511
                .::.|:.:|.         |||..:      :|||              |||      |..
Human  1158 KKPKRKRSEKPMAEDPVRPSSSVRNEGQS------DTNKRDLVGNDFKSIDRRTSTPNSRIQRAT 1216

  Fly   512 FVSTTSRDELSTTSKEIKDAPKNN---------------------------VEPPKKM------- 542
            .||.....:|.|.::.|:..|.:.                           :.||||.       
Human  1217 TVSQKKSSKLCTCTEPIRKVPVSKTPKKTHSDAKKGQNRSSNYLSCRTTPAIVPPKKFRQCPEPT 1281

  Fly   543 -------LRSRSKSCY------IDRPVELDEH-ITKNEVPLKKKYE-------SVDNSKEELIVT 586
                   |:...:..|      :|...:|.:| .|...|..:||.:       ||.|:|:     
Human  1282 STAEKLGLKKGPRKAYELSQRSLDYVAQLRDHGKTVGVVDTRKKTKLISPQNLSVRNNKK----- 1341

  Fly   587 LEAPAMLTTPTKSKTQCVKKKATQTRGRRKTIHSRDEIR--SLTAE------------------- 630
                 :||:......:.::.|:.:.|.|.....|.|..|  |.||:                   
Human  1342 -----LLTSQELQMQRQIRPKSQKNRRRLSDCESTDVKRAGSHTAQNSDIFVPESDRSDYNCTGG 1401

  Fly   631 ----AEENKK--ISPAKQTNEEIPIPTKSPLKRNARLLNRSKSCYM------DRLVISETEDP-- 681
                |..|:|  |.......|.|.....||...:|..||:..|..:      :.:::|.:|||  
Human  1402 TEVLANSNRKQLIKCMPSEPETIKAKHGSPATDDACPLNQCDSVVLNGTVPTNEVIVSTSEDPLG 1466

  Fly   682 -----AKKV----IKDISP-------------TKSDTTDNVL-------NFVDVRQTRGPSVIEA 717
                 |:.:    :|:..|             |::|..|..|       |:..:....|...:|.
Human  1467 GGDPTARHIEMAALKEGEPDSSSDAEEDNLFLTQNDPEDMDLCSQMENDNYKLIELIHGKDTVEV 1531

  Fly   718 PSLPKNRGKLRGVS-AEVKVKDKVLDRQRFIDYQAEMNAKWKQKPKDKKKEDEKLKECRREALKK 781
            .....:|.:|..:| .:.|.||.:        ...:...::..|..:.|..||.:  .|:..|..
Human  1532 EEDSVSRPQLESLSGTKCKYKDCL--------ETTKNQGEYCPKHSEVKAADEDV--FRKPGLPP 1586

  Fly   782 LSEKP-----KENSHRSTT-----NKRKNPTSV--PTVQNTNRGGFLTKGVDGPAPKLAKTDNAK 834
            .:.||     |..|.:||:     :|....:|.  |:::|.::|......|..|.|.:|      
Human  1587 PASKPLRPTTKIFSSKSTSRIAGLSKSLETSSALSPSLKNKSKGIQSILKVPQPVPLIA------ 1645

  Fly   835 PPPKKPVPKQPPAIETFSQQLQAADKAVLHPQ-PQCSRPVERKEAELARNQRTCNKVTFAEMELY 898
               :|||.:...:..            ||||| |..|            |::.| ||.|.|.:.:
Human  1646 ---QKPVGEMKNSCN------------VLHPQSPNNS------------NRQGC-KVPFGESKYF 1682

  Fly   899 HQKAEDSKKLQKKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKP 963
            ...:.                                       :.:.|||            :.
Human  1683 PSSSP---------------------------------------VNILLSS------------QS 1696

  Fly   964 VNDIRQHSRSILKWA-NQWLKHGSVDAVAE--QDVLMPIPPEFDSFKNYREIFVPLMKLELLSTI 1025
            |:|  ...:.:|||. ..:|..|.....|.  |.:..|:|..|.::.:|..:|.|||.|....|:
Human  1697 VSD--TFVKEVLKWKYEMFLNFGQCGPPASLCQSISRPVPVRFHNYGDYFNVFFPLMVLNTFETV 1759

  Fly  1026 ERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYC--CGMLKETFANLLELKF 1088
            .:::            :|...::..|:|..|.....:.|:..:.:|.  |.:.|:.:....:|.|
Human  1760 AQEW------------LNSPNRENFYQLQVRKFPADYIKYWEFAVYLEECELAKQLYPKENDLVF 1812

  Fly  1089 VS-------------GNVFDL---------------------TFEILKQDISEEKLKNIKQLTAR 1119
            ::             .::.||                     |...|.....|....|:.:|...
Human  1813 LAPERINEEKKDTERNDIQDLHEYHSGYVHKFRRTSVMRNGKTECYLSIQTQENFPANLNELVNC 1877

  Fly  1120 PVVDSLRVELGALSAVHQLRS-SPLCRRILKPTQTVNEVSLPKQPFTFKGCHK------------ 1171
            .|:.||......|.|:..|.| :.|.|.:|.|           .|..|  |.|            
Human  1878 IVISSLVTTQRKLKAMSLLGSRNQLARAVLNP-----------NPMDF--CTKDLLTTTSERIIA 1929

  Fly  1172 ----LNEHQENIVLHTYQRIIDDLQPS---LTLIQGPPGTGKSRVISELCLQTLYGNA------- 1222
                .||.|:..:...|..:  ...||   :.||.||||||||:.|..|..:.|..|.       
Human  1930 YLRDFNEDQKKAIETAYAMV--KHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDE 1992

  Fly  1223 ---AKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQ---------FHLLRFGMHEKMSHYSR 1275
               ||....::|:||.||.|||.::..:....:...:|:         .:|:|.|..:.::....
Human  1993 NSNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVL 2057

  Fly  1276 PFSLEAHFN---------------KAKE---QKLQRVSKENA------EILKKQHNDLKDEIQQL 1316
            .|||::..|               |.||   .:|..:|::.|      ||   |..:|.:.|.::
Human  2058 KFSLDSQVNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQRALCRGGREI---QRQELDENISKV 2119

  Fly  1317 -KEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLAN 1380
             ||:..|.|.  ::::|.:.:|.|.|                   .:..::|||.|||:...|..
Human  2120 SKERQELASK--IKEVQGRPQKTQSI-------------------IILESHIICCTLSTSGGLLL 2163

  Fly  1381 YVDF-------FDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNS 1438
            ...|       |...|||||.|..|..||.|:......::||||.:|||..|:|.||.::|...|
Human  2164 ESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQS 2228

  Fly  1439 MFDRIQRSLQTQLDKPGSYHLMHTKL--FKLSTQYRMHPEICRWPNQYFYEDQL-INAECTA-RF 1499
            |..|..|.|:..::     |.|.::|  .:|:.||||||:||.:|:.|.|...| .|.:..| |.
Human  2229 MMARFCRLLEENVE-----HNMISRLPILQLTVQYRMHPDICLFPSNYVYNRNLKTNRQTEAIRC 2288

  Fly  1500 AS--PLIPYCVINLKYTCDSNGAQ---NKSISNNEEARFVAKLLTEM-DKHMPSKRFSYGLISPY 1558
            :|  |..||.|.::     .:|::   |.|..|.:|.:.|.:::..: ||.......:.|:|:.|
Human  2289 SSDWPFQPYLVFDV-----GDGSERRDNDSYINVQEIKLVMEIIKLIKDKRKDVSFRNIGIITHY 2348

  Fly  1559 QNQCYALSQVI--------PSHMNITPQTVDSYQGLEKDVIIISNARTR----GCGFLTNYQRLN 1611
            :.|...:.:.:        |:.::    |||::||.:||.:|::..|..    ..|||.:.||||
Human  2349 KAQKTMIQKDLDKEFDRKGPAEVD----TVDAFQGRQKDCVIVTCVRANSIQGSIGFLASLQRLN 2409

  Fly  1612 VALTRPRRCLVICGNFED-----------------------------LKSVEMWRNLLDDARKR 1646
            |.:||.:..|.|.|:...                             ||..:.|..|:.||:||
Human  2410 VTITRAKYSLFILGHLRTLMQLLPRSFCVHVNHSPFFSPEPKYLHWALKENQHWNQLIQDAQKR 2473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7504NP_001137907.1 FHA 4..96 CDD:238017
FHA <10..101 CDD:224630
AAA_11 1171..1428 CDD:289831 85/326 (26%)
AAA_19 1194..1251 CDD:289986 25/69 (36%)
YtxH <1293..1347 CDD:295162 15/60 (25%)
AAA_12 1435..1626 CDD:289832 63/212 (30%)
SETXNP_001338457.1 SEN1_N 37..>351 CDD:315409
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1158..1219 12/66 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1237..1258 1/20 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1385 9/33 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1604 6/24 (25%)
AAA_11 1933..2218 CDD:315699 84/310 (27%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2070..2087 3/16 (19%)
AAA_12 2225..2424 CDD:315700 63/212 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2503..2525
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2585..2606
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2626..2706
Necessary for nuclear localization 2690..2706
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 79 1.000 Domainoid score I8722
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 218 1.000 Inparanoid score I3591
Isobase 1 0.950 - 0 Normalized mean entropy S6656
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D62494at2759
OrthoFinder 1 1.000 - - FOG0000219
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101455
Panther 1 1.100 - - LDO PTHR10887
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.820

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