DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and SLC4A1AP

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_060628.3	Gene:	SLC4A1AP / 22950	HGNCID:	13813	Length:	742	Species:	Homo sapiens

Alignment Length:	734	Identity:	151/734 - (20%)
Similarity:	252/734 - (34%)	Gaps:	201/734 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GARLILHNGTNLMGRHSRCRIILGGQYQFVSREHANIIVSEKGVEVE-----------SLNPLNG 66
            |.|.:......|.||.|.|.:.|  ::..|||.||.:.....|.:.|           .|...:|
Human   125 GTRSLKGTSYCLFGRLSGCDVCL--EHPSVSRYHAVLQHRASGPDGECDSNGPGFYLYDLGSTHG 187

  Fly    67 LFINGGKLGDKINRLAVAEGSTISLGVTGVNLNEITGIHAIFILKKKEPVVEEIVLSSDDDDTTP 131
            .|:|..::..: ....|..|..:..|          |...:|||:..|         .|.:..:.
Human   188 TFLNKTRIPPR-TYCRVHVGHVVRFG----------GSTRLFILQGPE---------EDREAESE 232

  Fly   132 LPAVRCPTGTQPTEFNLKQQI----PNFGGKQDPGQEEEVLPSSSNLHLPKLTEVKQEIVKHTSE 192
            |      |.||..|...:|||    ...|...|   |||.:.:|..    |:....|:      :
Human   233 L------TVTQLKELRKQQQILLEKKMLGEDSD---EEEEMDTSER----KINAGSQD------D 278

  Fly   193 EIQNIFGEPSDAILNSVLELNPYLYNKLTNKTANNEITRKKIHDGDCIELDTDTDRRSISEAQKA 257
            |:...:|...||:.:.. |.||.:                       :|...:.:...|.:.:||
Human   279 EMGCTWGMGEDAVEDDA-EENPIV-----------------------LEFQQEREAFYIKDPKKA 319

  Fly   258 EDPSAEREVDD-EEEYDE-------------------SFAMSQAVIREMKAEMHVSDGEEDFLLT 302
            .....:||.:: |.|:||                   ...:::|:....|.|..:....|...:.
Human   320 LQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMIQCSLEACRIL 384

  Fly   303 NGMGNLPEGSPSNQA-----YDDIVYVSDSDDDELYDK--VADWSKLLSQKVVPDVIEMSQTY-P 359
            :.:|.|.:.:.|.:.     .|:..|  |||||...|:  :.:..:|...|....:.|..:|: .
Human   385 DTLGLLRQEAVSRKRKAKNWEDEDFY--DSDDDTFLDRTGLIEKKRLNRMKKAGKIDEKPETFES 447

  Fly   360 LENEHKDSDSDLDIGAKKPKRTLRI-SSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADS 423
            |..:..|::.:|...:::.|.:.:: |.|..:||.|..:        ...||.|..|.|.|
Human   448 LVAKLNDAERELSEISERLKASSQVLSESPSQDSLDAFM--------SEMKSGSTLDGVSR---- 500

  Fly   424 TTPDLPAVRKLSVSSIDSVYENKQTKLNSKLKSCLKSPTKTSVDNMENMTETKSCSNRQREQIVA 488
                    :||.:.:.:      ..|...:||..:|......:..::. |||         |...
Human   501 --------KKLHLRTFE------LRKEQQRLKGLIKIVKPAEIPELKK-TET---------QTTG 541

  Fly   489 SRNEPTNICPQKIETNKTSTRKRFVSTT------SRDELSTTSKEIKDAPKNNVEPPKKMLRSRS 547
            :.|:...:........|..::.:..:.|      .|.||..|...:||.|:  ||..::......
Human   542 AENKAKKLTLPLFGAMKGGSKFKLKTGTVGKLPPKRPELPPTLMRMKDEPE--VEEEEEEEEEEE 604

  Fly   548 KSCYIDRPVELDEHITKNEVPLKKKYESVDNSKEELIVTLEAPAMLTTPTKSKTQCVKKKATQTR 612
            |        |.:||       .|||.|....|:.:..:..||......|   .|.....|.|||.
Human   605 K--------EKEEH-------EKKKLEDGSLSRPQPEIEPEAAVQEMRP---PTDLTHFKETQTH 651

  Fly   613 GRRKTIHSRDEIRSLTAEAEENKKISPAKQTNEEI--PIPTKSPLKRNARLLNRSKSCYMDRLVI 675
                      |..|..:|.|:||......:|....  |..:|:..:::...|.:.|
Human   652 ----------ENMSQLSEEEQNKDYQDCSKTTSLCAGPSASKNEYEKSRGELKKKK--------- 697

  Fly   676 SETEDPAKKVIKDISPTKS 694
              |..|.|     :.||.|
Human   698 --TPGPGK-----LPPTLS 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017	22/93 (24%)
		FHA	<10..101	CDD:224630	22/98 (22%)
		AAA_11	1171..1428	CDD:289831
		AAA_19	1194..1251	CDD:289986
		YtxH	<1293..1347	CDD:295162
		AAA_12	1435..1626	CDD:289832
SLC4A1AP	NP_060628.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910