DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Helz2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_006500664.1	Gene:	Helz2 / 229003	MGIID:	2385169	Length:	2970	Species:	Mus musculus

Alignment Length:	1439	Identity:	287/1439 - (19%)
Similarity:	488/1439 - (33%)	Gaps:	500/1439 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   511 RFVSTTSRDELSTTSKE----IKDAPKNNVEPPKK----------------MLRSR--SKSCYID 553
            ||..:..|.:...:.:|    ||..|...:|.|..                |||.:  |.:||.:
Mouse  1677 RFAPSIIRSDRQLSYEEAEELIKRHPGAGLELPAHLDSVEACVVAACYFSWMLRRQRLSAACYYE 1741

  Fly   554 RPVELDE---------HITKNEVPLKKKYESVDNSKEELIVTLEAPAMLT------TPTKSKTQC 603
            .|   ||         ||...|..::     .::...|.:|:.:....||      ||::.:...
Mouse  1742 PP---DEDSVLGFRTAHIMVQEYMIQ-----FNSHVAEFLVSNKHTQTLTPLRWQPTPSRQQLDS 1798

  Fly   604 VKKKATQTRGRRKTIHSRDEIRSLTAEAEENKKISPAKQTNEEIPIPTKSPLKRNARLLNRSKSC 668
            |.||   .||....        ||......|...:|.||                   |:...|.
Mouse  1799 VFKK---YRGLVPL--------SLHLCHHSNTDYTPNKQ-------------------LHLLTSL 1833

  Fly   669 YMDRLVISETEDPAKKV----IKDISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLR- 728
            :....:.:.|:|.::.|    ..|:.|:.:...      :|:|:..|.||....|..|.:..:.
Mouse  1834 WKQVQLAAGTQDYSQMVDLIAADDMHPSLAPAC------LDLRRALGRSVFGRSSQGKQQPAVHH 1892

  Fly   729 ---------GVSAEVKVKDKVLDR--------------QRFID--------------------YQ 750
                     ..|...:..|.||.|              .|.||                    |.
Mouse  1893 SLQVDWYTWATSPIRRYLDVVLQRLILLALGHRGSTYSNRDIDGLCLDFSRQYASAQSYQRRAYS 1957

  Fly   751 AEMNAKWKQKPKDK---KKEDEKLKEC-------RREALK----------KLSEKPKENSHRSTT 795
            ..:..:.|.:|::|   ..:.|....|       .||.|.          :|:|.|:|...::..
Mouse  1958 LHLAIQLKSQPQNKLGFVVDVEMGARCFKVLFPINRETLPDPCPIHYHSLQLAEHPQELVSQTGV 2022

  Fly   796 NK--RKNPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPKQPPAIETFSQQLQAA 858
            ..  |:...||                  .|.||            |:|....:::..:|.:.||
Mouse  2023 RLVWRRRMYSV------------------QASKL------------PLPLLGTSLDPHTQTVDAA 2057

  Fly   859 DKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKV 923
                          :..|...|.:.||.               .|.:..:|::.::.|..:.||:
Mouse  2058 --------------LWMKLLMLLKEQRW---------------PEIAALIQEQDKRFHPREKVKI 2093

  Fly   924 H---C---IERVKGASSKVQGRKECIKLRLSSYRER-------REW---------IRRENKPVND 966
            |   |   :|.|...     |..:.::::|.|..:|       :.|         :....:|.:.
Mouse  2094 HQSRCGHFVEVVYEL-----GSGDTLQVQLGSSLQRGFLAPTLKLWTVVPGFSLCLEHMERPGDC 2153

  Fly   967 IRQHSRSILKWANQWLKHGS--------------VDAVAEQD--VLMPIPPEFDSFKNYREIFVP 1015
            ...|....|:  :|:|:.|.              .:||.|.|  ||..:...:|:.:.
Mouse  2154 FSSHVHQALQ--DQYLQVGEYSGAWGPRCALESLTNAVTENDSIVLHDVHISWDTSQG------- 2209

  Fly  1016 LMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKP------------FGKFV-- 1066
                :|..|.:.:.....:...::..      ..|| |..|:...|            .|.|:
Mouse  2210 ----QLQGTFQLEAAFLQEKCINIHF------GCCY-LCIRLEGLPLPLDSSLPGPSGLGPFLNI 2263

  Fly  1067 ---LYTLYCCGMLKETFANLLELKFVSGNVFD------------------------------LTF 1098
               .||....|:..:....|....:...||.|                              .|.
Mouse  2264 DPNTYTWVAHGLSGDWDHELAGGDWDQENVDDRQEAPKQVYFLIHHMTMEKVPEEVLRPSARFTV 2328

  Fly  1099 EILKQDI----SEEKLKNIKQLTARPVVDSLRVEL----------GALSAVHQLR---------- 1139
            |:|.:.:    .||.::.:|  ||.|:|.|:.:.|          |....|.:||
Mouse  2329 EVLSKQLPDLRKEEAVRQLK--TASPLVISIALGLPIPEIRWPISGPRRLVSELRWPIPGPRRPV 2391

  Fly  1140 -------SSPLCRRILKPTQTVNEV---SLPKQPFTFK----------------GCHKLNEHQEN 1178
                   |.| |..|.:|.:::.|.   :.|:|....|                |.||||:.|:.
Mouse  2392 SEPHRPMSGP-CGPISEPCRSIPEPCRGNWPRQHSFHKASTSRFLERQNYNIPAGHHKLNQSQDR 2455

  Fly  1179 IVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCL-------QTLYGNAAKTLDRK-----IL 1231
            .|...       ||...|:|||||||||:.|...:..       :.:..:::.:.:.:     :|
Mouse  2456 AVRSA-------LQKQFTVIQGPPGTGKTVVGFHIVYWFHRSNQEQMPTDSSPSGEEQLGGPCVL 2513

  Fly  1232 ICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLR-FGMHEKMSHYSRP-FSLEAHFNKAKE-----Q 1289
            .|..||.:||.:.|||     :..:.:...|| :|...:.:.:..| .|..:.|.|..:     |
Mouse  2514 YCGPSNKSVDVLGGLL-----LRRKTEMKPLRVYGEQAEATEFPLPGVSNRSLFGKTSQEGRPNQ 2573

  Fly  1290 KLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREE 1354
            .|:.::..:.  :::..|....||::.             ..|.:|.|           :..:|:
Mouse  2574 SLRSITLHHR--IRQAPNPYAAEIRKF-------------DAQLREGK-----------IFSKED 2612

  Fly  1355 FEISHMCVTRAN---------IICT---TLSSCVKLANYVDFFDICIVDEATQCTEPWTLLPM-R 1406
            ..:....:.:|.         |:||   ..|..:|:.|....    ::|||...|||.||:|: .
Mouse  2613 LRVYRRVLGKARKHELERHSVILCTCSCAASKSLKILNVRQI----LIDEAGMATEPETLIPLVC 2673

  Fly  1407 FGLT--HMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLST 1469
            |..|  .:||:||.:||..||.|::....|:..|:|:|                 .|.....|.|
Mouse  2674 FSKTVEKVVLLGDHKQLRPVVKSEQLQSLGMDRSLFER-----------------YHRDAIMLDT 2721

  Fly  1470 QYRMHPEICRWPNQYFYEDQLINAECTARFASPL----IPYCVI--------NLKYTCDSNGAQN 1522
            |||||.:||.:|:..||..:|.......|..|.|    .|.|.:        ..|....:.....
Mouse  2722 QYRMHKDICSFPSVEFYGGKLKTWSDLRRLPSILGHTGKPSCSVIFGSVQGHEQKLLVSTEDGNE 2786

  Fly  1523 KSISNNEEARFVAKLLTE--MDKHMPSKRFSYGLISPYQNQCYALSQVIPSH--MNITPQTVDSY 1583
            .|.:|.||...|.:::.:  :|:.:..|  ...:::||..|..|:|:.:...  ..:|..::...
Mouse  2787 NSRANPEEVTQVVRIIKQLTLDRTVDPK--DIAVLTPYNAQAAAISRGLMQRGVTGVTVTSITKS 2849

  Fly  1584 QGLEKDVIIISNART----------------RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKS 1632
            ||.|...:|:|..||                :..||:.:..::|||:||.:..|.|.|:...|:.
Mouse  2850 QGSEWRYVIVSTVRTCPRSDVDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEALCIIGDHLLLRC 2914

  Fly  1633 VEMWRNLLD 1641
            ..:|..|||
Mouse  2915 CPLWHRLLD 2923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	69/290 (24%)
		AAA_19	1194..1251	CDD:289986	20/68 (29%)
		YtxH	<1293..1347	CDD:295162	6/53 (11%)
		AAA_12	1435..1626	CDD:289832	52/222 (23%)
Helz2	XP_006500664.1	DEAD-like_helicase_N	760..990	CDD:391939
		AAA_12	961..1161	CDD:372468
		RNB	1567..1924	CDD:214935	57/290 (20%)
		DEXXc_HELZ2-C	2448..2724	CDD:350798	78/334 (23%)
		AAA_12	2704..2909	CDD:372468	53/223 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740