DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7504 and C41D11.6

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_491376.1	Gene:	C41D11.6 / 183377	WormBaseID:	WBGene00016565	Length:	852	Species:	Caenorhabditis elegans

Alignment Length:	1016	Identity:	184/1016 - (18%)
Similarity:	321/1016 - (31%)	Gaps:	356/1016 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 NSKEELIVTLEAPAMLTTPTKSKTQCVKKKATQTRGRRKTIHS----------RDEIRSLTAEAE 632
            |..||:...:|.||          ..|:.:|...||:...|..          ...:.:..|...
Worm    17 NRDEEMPEAVEPPA----------NVVEGQAEANRGQAANIGEVYPPVKAEGPGSPVLAAGAGGA 71

  Fly   633 ENKKISPAKQTNEEIPIPTKSPLKRN----ARLLNRSKSCYMDRLVISETEDPAKKVIKDISPTK 693
            .|..|.|.:   .:|||...:....|    .|:.|..:...|.|       .|..:::::    .
Worm    72 PNVPILPPQ---NQIPINLNNNNHDNEQERERVPNNMRFLRMQR-------RPWAEMVEE----D 122

  Fly   694 SDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLR---GVSAEVKVKDKVLDR----------QR 745
            .|..::...|:::   :||:       |:.....|   |...:::.|..|..|          |.
Worm   123 QDNKEHEFEFLEI---QGPA-------PQRHHPFREHYGAQPDLEPKISVAKRLAAETTLEDVQS 177

  Fly   746 FIDYQAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEKPK----ENSHRSTTNKRKNPTSVPT 806
            |.:|.|                    .|..|.||.:  :||.    |.|....|.....|.::.|
Worm   178 FRNYTA--------------------GEIHRPALHE--DKPPNTMVELSLNFITKLPSEPHALAT 220

  Fly   807 VQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPKQPPAIETFS----------------QQL 855
            :...|          |...|:|...      |:.|....|.:...:                :|.
Worm   221 IVENN----------GTVYKVAMVF------KEVVANDRPDLMYMNFTKWSYDVTSRKYAELKQY 269

  Fly   856 QAADKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDD 920
            ...|..::|      :.|:|::.......:|.:::...:...|.|.:|.| .:|:|:     ::.
Worm   270 YKGDTIMIH------KVVKRRDVAPESFMKTFDQIRNMKAHNYWQVSEFS-LVQRKI-----SEP 322

  Fly   921 VKVHCIERVKGA--SSK--VQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWANQW 981
            .....:.|..|.  |.|  |.|..|.:.:...::.:.|                       |.|.
Worm   323 QPFSLVGRAAGGRHSKKLAVCGVTEIVTVSEDTFNDNR-----------------------APQG 364

  Fly   982 LKHGSVDAVAEQDVLMP----------------------------IPPEFDSF------KNYREI 1012
            .:   .||||...||:|                            :.|:..:|      |.|..:
Worm   365 YR---ADAVAFTPVLIPGQLLKSLLPGTPHIVVRRETAAQSKSWDLRPQVINFGIMGARKAYPFL 426

  Fly  1013 FVP----------------LMKL------ELLSTIERDYKINNKNTFSVSLINVETQD------- 1048
            .:|                :.||      .::||...:   .:|..:..:|.:|...:
Worm   427 HLPNYMAGRSPNTEDAWRGVRKLGHHGLSAMISTSNMN---QDKFHYETTLQHVRELEGSMKVSF 488

  Fly  1049 -MCY--RLVTRVNSK---------PFGKFV------------LYTLYCCGMLKETFANLLELKFV 1089
             :.|  |.|...|.|         |.|.||            ..|...|.:|:..
Worm   489 ALQYPGRPVKACNWKNGTKFSIETPAGTFVPAAVDHAVQSTDAITTIECRILRPA---------- 543

  Fly  1090 SGNVFDLTFEILKQDISEEKLKNIKQ-----LTARPV--VDSLRVELGALSAVHQLRSSPLCRRI 1147
                 |....||........:|..|:     |.|.||  ||::......|:....|...|:.
Worm   544 -----DNAVHILAVGEDAVLIKQTKEADGHLLAATPVVPVDTVLDRNKGLATFAALNGGPII--- 600

  Fly  1148 LKPTQTVNEVSLPKQPFTFKGCHKLNEHQENIVL----HTYQRIIDDLQPSLTLIQGPPGTGKSR 1208
                 ..|.::.|.:.|.:          :|.|.    .|:.:...||:.....:.|..||||::
Worm   601 -----ASNGLNYPHKEFRY----------QNFVCSAQQSTFIQACCDLKLGALSLDGAFGTGKTK 650

  Fly  1209 VISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGS--------VLRVMN---RDQFHLL 1262
            .::...::....|.     ::::|.|::|.||..|...:.|        |:|.|:   ||:
Worm   651 AVAATAIEFSNQNI-----QRVIISANNNGAVKAIHDAIRSLAPRGRVKVVRAMSARLRDE---- 706

  Fly  1263 RFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYL 1327
              ...|.::....|......|.:.    :|.|::.|   ::..|..:.|..:.|.....|.|..|
Worm   707 --AKPEVLTEDDFPILWREVFTEV----VQSVNRPN---VRGTHPAIIDAARHLNAHGLLPSPML 762

  Fly  1328 LQQLQQKEKKLQLISNQLSPPLTQREEFEI--SHMCVTRANIICTTLSSCVKLANYVDF------ 1384
            ..:::.:.|         :|..|:.....|  :.|.:....||..|.:|.....|.:.|
Worm   763 NNEIRVRCK---------APYKTEPPAHTIWTALMKIHETAIIIGTTASIHTALNDIGFASKANE 818

  Fly  1385 FDICIVDEATQCTEPWTLLPM--------RFGLTHMVLVGD 1417
            ..:.::|||:|       :||        .|.....|||||
Worm   819 IGLVMLDEASQ-------IPMIKIGGLATHFPKAKFVLVGD 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	58/278 (21%)
		AAA_19	1194..1251	CDD:289986	13/64 (20%)
		YtxH	<1293..1347	CDD:295162	9/53 (17%)
		AAA_12	1435..1626	CDD:289832
C41D11.6	NP_491376.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810