Protein Alignment Setx and hzl-1

DIOPT Version :10

• Sequence 1: NP_001137907.1
• Gene: Setx / 38904
• FlyBaseID: FBgn0035842
• Length: 1676
• Species: Drosophila melanogaster
• Sequence 2: NP_506213.2
• Gene: hzl-1 / 179760
• WormBaseID: WBGene00008099
• Length: 1099
• Species: Caenorhabditis elegans
• Alignment Length: 1212
• Identity: 258/1212 - (21%)
• Similarity: 424/1212 - (34%)
• Gaps: 320/1212 - (26%)

  Fly   537 EPPKKMLRSRSKSCYIDRPVELDEHITKNEVPLKKKYESVDNSKEELIVTLEAPAMLTTPTKSKT 601
            ||.:::..|.:.|.|                  ::.||..::..::.               ..:
 Worm    17 EPTREVQSSYNNSYY------------------RRDYEEEEDDVQQY---------------HTS 48

  Fly   602 QCVKKKATQTRGRRKTIHSRDEIRSLT-AEAEENKKISPAKQTNEEIPIPTKSPLKRNARLLNRS 665
            .....|::||...|.::.....:.|.| :|.|:|.......|     |..|.|..|:.
 Worm    49 HIASIKSSQTTSYRSSVVQNSSVYSRTFSEKEQNAFSKFYVQ-----PPETNSRQKKK------- 101

  Fly   666 KSCYMDRLVISETEDPAKKVIKDISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGV 730
                      :|.|...:|.:|  |...||    .:||.....:.||:.    :.||.|...|.:
 Worm   102 ----------TEIESEVEKELK--SYKHSD----AINFAARTFSWGPNF----NSPKPRQVFRDI 146

  Fly   731 SAEVKVKDKVLDRQRFIDYQAEMNAKWKQKPKDKKKEDEK--LKECRR--EALKKLSEKPKENSH 791
            |.              ..|:..:.|.::.    ...||.|  |..|..  ..|.:...:..|.:.
 Worm   147 ST--------------YSYERGIRAYFRV----LSAEDNKYILIACHANLHGLHRGDLRFVEVND 193

  Fly   792 RSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPKQPPAIETFSQQLQ 856
            |:.|...:|.:.:         |.|..|......:|:|..||        |...|.|:..|
 Worm   194 RTITKGSENYSVI---------GMLFPGDVVAVTELSKKSNA--------PSIAPTIKNVS---- 237

  Fly   857 AADKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEME------LYHQKAEDSKKL-QKKLR- 913
                    |...|...|.:.   :...:::..:|.||.:.      ..|.:|.|..:: :|||:
 Worm   238 --------PHDPCIWEVNKM---VVLQRKSIIRVNFAMLNNGAAIVEGHTEAMDVIEIDRKKLKT 291

  Fly   914 --------------KVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPV 964
                          ||.|::.......|.:...:||           |.||          :..:
 Worm   292 DMMYYGTAFIPEKSKVKFSEGFHRQHWEDLMALTSK-----------LPSY----------SNSL 335

  Fly   965 NDIRQHSRSILKWANQWLKHGSVDA---------------VAEQDVLMPIPP-------EFDSFK 1007
            ..|..|  |:.:......|.| |||               ||::.|:|....       .||. :
 Worm   336 GTIYTH--SLCERQTNMFKIG-VDAFNSSIYSLNTEASVLVAQKCVIMGSSAAQTVSNGRFDG-R 396

  Fly  1008 NYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYC 1072
            |::           ::.|.|     ....|..|:.|...|.      |.....|..|..:
 Worm   397 NFQ-----------MTNIHR-----KSQNFRFSIDNPSKQP------TEGRWNPNQKIEI----- 434

  Fly  1073 CGMLKETFANLLELKFVSGN--VFDLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAV 1135
             ....|:....:|...:..|  ..::|..|.|   :..||.|. |.....|..|..:|...|...
 Worm   435 -NGQGESLKTSIETVVLGNNRKSLEITATIPK---NNNKLLNF-QTGTWIVSQSQFLETPRLDCE 494

  Fly  1136 HQLRSSPLC--RRIL------KPTQTVNEVSLPKQ-PFTFKGCHKLNEHQENIVLHTYQRIIDDL 1191
            ...:.||..  |||:      .|..:...::..|| .|..|....||::|...|    ..|:..:
 Worm   495 FLQKMSPSSNGRRIVTALYGGSPINSTGNINWNKQFEFPSKIPIGLNQYQNQYV----SMILSGV 555

  Fly  1192 QPSLTLIQGPPGTGKSRVI--SELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVM 1254
              .|.|...|.|.|||..|  :.:.||..| ..:::.:::.|:...||.|.   |.|:...|::.
 Worm   556 --PLILGNSPFGCGKSMTIVTAAVELQKKY-MRSESFNKQQLLVTQSNNAG---VNLIEFALKLH 614

  Fly  1255 NRDQFHLLRFGMH--------EKMSHYSRPFSLEAHFNK-AKEQKLQRVSKENAEILKKQHNDLK 1310
            ..|....||:...        ...:....|..:|..|.: |...::|   |||.|.|.::..  |
 Worm   615 KCDHIRFLRYVSESNWNSLPDSSKTELDMPILMEDEFFEWATNTEIQ---KENGENLTREMK--K 674

  Fly  1311 DEIQQLKEKTNLTSTYLLQQLQQKEKKL--QLISNQLSPPLTQ---REEFEISHMCVTRANIICT 1370
            ..::|..:|.:....     |..:.|::  .::.||.....:|   :|.|    ..:...:||.:
 Worm   675 AIVEQSTQKYHCKGI-----LVGEAKRIYENILKNQREHKPSQAILKEAF----FALYAPDIIVS 730

  Fly  1371 TLSSCVKLANYVDFFDICIV--DEATQCTEPWTLLPM--RFGLTHMVLVGDMQQLPAVV---LSK 1428
            |..|...|.......|:..:  |||:|..| .||:.:  :|......||||:.||||..   |..
 Worm   731 TADSIHNLLENNVLRDVSNIQFDEASQVPE-HTLISLLHKFPNASFGLVGDINQLPAYCDDDLQG 794

  Fly  1429 KAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFK---LSTQYRMHPEICRWPNQYFYEDQL 1490
            ...|:|:..:| .|..|.                |:|.   |...||.||...:..:..||..||
 Worm   795 LLKDYGIGKTM-ARASRD----------------KMFPQSILRLVYRCHPTTTKILSDLFYNGQL 842

  Fly  1491 IN-AECTAR----------FASPLIPYCVINLKYTCDSNG-AQNKSISNNEEARFVAK---LLTE 1540
            |: .|...|          :.:...|..|:|    .:.:| ....|::||.|...|.:   |||:
 Worm   843 ISGVEKNQRDEFMRMRPDIWPNSSFPILVLN----HEKDGYRMGTSVANNSEKDQVVRIVSLLTK 903

  Fly  1541 MDKHMPSKRFSYGLISPYQNQCYALSQVIPSHMNITPQTVDSYQGLEKDVIIISNARTRGCGFLT 1605
            ..|.........|:||.|:.|...|:..: ...::...|:|::||.|::|:|:.........|:.
 Worm   904 KVKGYGLSESDIGIISFYKAQTSLLADAL-KKTDVKCGTIDAFQGTEREVMIVCCTNKNPSLFMQ 967

  Fly  1606 NYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRK 1647
            ...|:|||::|.|:..:|.||...||..:.|..:...|:..|
 Worm   968 EGTRVNVAMSRARQATIIIGNIAKLKKAKHWDTIAQSAQINK 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Setx	NP_001137907.1	FHA	12..94	CDD:438714
		AAA_11	1175..1428	CDD:404072	67/275 (24%)
		DNA2	<1299..1646	CDD:440729	94/376 (25%)
hzl-1	NP_506213.2	AAA_11	544..786	CDD:404072	64/266 (24%)
		DNA2	<693..993	CDD:440729	84/326 (26%)