DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and C44H9.4

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_506213.2	Gene:	C44H9.4 / 179760	WormBaseID:	WBGene00008099	Length:	1099	Species:	Caenorhabditis elegans

Alignment Length:	1212	Identity:	258/1212 - (21%)
Similarity:	424/1212 - (34%)	Gaps:	320/1212 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   537 EPPKKMLRSRSKSCYIDRPVELDEHITKNEVPLKKKYESVDNSKEELIVTLEAPAMLTTPTKSKT 601
            ||.:::..|.:.|.|                  ::.||..::..::.               ..:
Worm    17 EPTREVQSSYNNSYY------------------RRDYEEEEDDVQQY---------------HTS 48

  Fly   602 QCVKKKATQTRGRRKTIHSRDEIRSLT-AEAEENKKISPAKQTNEEIPIPTKSPLKRNARLLNRS 665
            .....|::||...|.::.....:.|.| :|.|:|.......|     |..|.|..|:.
Worm    49 HIASIKSSQTTSYRSSVVQNSSVYSRTFSEKEQNAFSKFYVQ-----PPETNSRQKKK------- 101

  Fly   666 KSCYMDRLVISETEDPAKKVIKDISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGV 730
                      :|.|...:|.:|  |...||    .:||.....:.||:.    :.||.|...|.:
Worm   102 ----------TEIESEVEKELK--SYKHSD----AINFAARTFSWGPNF----NSPKPRQVFRDI 146

  Fly   731 SAEVKVKDKVLDRQRFIDYQAEMNAKWKQKPKDKKKEDEK--LKECRR--EALKKLSEKPKENSH 791
            |.              ..|:..:.|.::.    ...||.|  |..|..  ..|.:...:..|.:.
Worm   147 ST--------------YSYERGIRAYFRV----LSAEDNKYILIACHANLHGLHRGDLRFVEVND 193

  Fly   792 RSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPKQPPAIETFSQQLQ 856
            |:.|...:|.:.:         |.|..|......:|:|..||        |...|.|:..|
Worm   194 RTITKGSENYSVI---------GMLFPGDVVAVTELSKKSNA--------PSIAPTIKNVS---- 237

  Fly   857 AADKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEME------LYHQKAEDSKKL-QKKLR- 913
                    |...|...|.:.   :...:::..:|.||.:.      ..|.:|.|..:: :|||:
Worm   238 --------PHDPCIWEVNKM---VVLQRKSIIRVNFAMLNNGAAIVEGHTEAMDVIEIDRKKLKT 291

  Fly   914 --------------KVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPV 964
                          ||.|::.......|.:...:||           |.||          :..:
Worm   292 DMMYYGTAFIPEKSKVKFSEGFHRQHWEDLMALTSK-----------LPSY----------SNSL 335

  Fly   965 NDIRQHSRSILKWANQWLKHGSVDA---------------VAEQDVLMPIPP-------EFDSFK 1007
            ..|..|  |:.:......|.| |||               ||::.|:|....       .||. :
Worm   336 GTIYTH--SLCERQTNMFKIG-VDAFNSSIYSLNTEASVLVAQKCVIMGSSAAQTVSNGRFDG-R 396

  Fly  1008 NYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYC 1072
            |::           ::.|.|     ....|..|:.|...|.      |.....|..|..:
Worm   397 NFQ-----------MTNIHR-----KSQNFRFSIDNPSKQP------TEGRWNPNQKIEI----- 434

  Fly  1073 CGMLKETFANLLELKFVSGN--VFDLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAV 1135
             ....|:....:|...:..|  ..::|..|.|   :..||.|. |.....|..|..:|...|...
Worm   435 -NGQGESLKTSIETVVLGNNRKSLEITATIPK---NNNKLLNF-QTGTWIVSQSQFLETPRLDCE 494

  Fly  1136 HQLRSSPLC--RRIL------KPTQTVNEVSLPKQ-PFTFKGCHKLNEHQENIVLHTYQRIIDDL 1191
            ...:.||..  |||:      .|..:...::..|| .|..|....||::|...|    ..|:..:
Worm   495 FLQKMSPSSNGRRIVTALYGGSPINSTGNINWNKQFEFPSKIPIGLNQYQNQYV----SMILSGV 555

  Fly  1192 QPSLTLIQGPPGTGKSRVI--SELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVM 1254
              .|.|...|.|.|||..|  :.:.||..| ..:::.:::.|:...||.|.   |.|:...|::.
Worm   556 --PLILGNSPFGCGKSMTIVTAAVELQKKY-MRSESFNKQQLLVTQSNNAG---VNLIEFALKLH 614

  Fly  1255 NRDQFHLLRFGMH--------EKMSHYSRPFSLEAHFNK-AKEQKLQRVSKENAEILKKQHNDLK 1310
            ..|....||:...        ...:....|..:|..|.: |...::|   |||.|.|.::..  |
Worm   615 KCDHIRFLRYVSESNWNSLPDSSKTELDMPILMEDEFFEWATNTEIQ---KENGENLTREMK--K 674

  Fly  1311 DEIQQLKEKTNLTSTYLLQQLQQKEKKL--QLISNQLSPPLTQ---REEFEISHMCVTRANIICT 1370
            ..::|..:|.:....     |..:.|::  .::.||.....:|   :|.|    ..:...:||.:
Worm   675 AIVEQSTQKYHCKGI-----LVGEAKRIYENILKNQREHKPSQAILKEAF----FALYAPDIIVS 730

  Fly  1371 TLSSCVKLANYVDFFDICIV--DEATQCTEPWTLLPM--RFGLTHMVLVGDMQQLPAVV---LSK 1428
            |..|...|.......|:..:  |||:|..| .||:.:  :|......||||:.||||..   |..
Worm   731 TADSIHNLLENNVLRDVSNIQFDEASQVPE-HTLISLLHKFPNASFGLVGDINQLPAYCDDDLQG 794

  Fly  1429 KAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFK---LSTQYRMHPEICRWPNQYFYEDQL 1490
            ...|:|:..:| .|..|.                |:|.   |...||.||...:..:..||..||
Worm   795 LLKDYGIGKTM-ARASRD----------------KMFPQSILRLVYRCHPTTTKILSDLFYNGQL 842

  Fly  1491 IN-AECTAR----------FASPLIPYCVINLKYTCDSNG-AQNKSISNNEEARFVAK---LLTE 1540
            |: .|...|          :.:...|..|:|    .:.:| ....|::||.|...|.:   |||:
Worm   843 ISGVEKNQRDEFMRMRPDIWPNSSFPILVLN----HEKDGYRMGTSVANNSEKDQVVRIVSLLTK 903

  Fly  1541 MDKHMPSKRFSYGLISPYQNQCYALSQVIPSHMNITPQTVDSYQGLEKDVIIISNARTRGCGFLT 1605
            ..|.........|:||.|:.|...|:..: ...::...|:|::||.|::|:|:.........|:.
Worm   904 KVKGYGLSESDIGIISFYKAQTSLLADAL-KKTDVKCGTIDAFQGTEREVMIVCCTNKNPSLFMQ 967

  Fly  1606 NYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRK 1647
            ...|:|||::|.|:..:|.||...||..:.|..:...|:..|
Worm   968 EGTRVNVAMSRARQATIIIGNIAKLKKAKHWDTIAQSAQINK 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	69/279 (25%)
		AAA_19	1194..1251	CDD:289986	17/58 (29%)
		YtxH	<1293..1347	CDD:295162	12/55 (22%)
		AAA_12	1435..1626	CDD:289832	51/208 (25%)
C44H9.4	NP_506213.2	AAA_11	539..786	CDD:289831	66/271 (24%)
C44H9.4	NP_506213.2	UvrD_C_2	823..988	CDD:304668	45/169 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810