DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and DNA2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_006717743.1	Gene:	DNA2 / 1763	HGNCID:	2939	Length:	1090	Species:	Homo sapiens

Alignment Length:	930	Identity:	203/930 - (21%)
Similarity:	358/930 - (38%)	Gaps:	263/930 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   865 PQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLR-----KVH--FNDDVK 922
            ||.|.|.|     ::.:::..|||......|::..........|:.|:.     |:|  :....|
Human   264 PQMQLSLP-----SDNSKDNSTCNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYK 323

  Fly   923 VHCIERVKG-ASSKVQGRKECIKLRLSSYRERRE-------WIRR-ENKPVNDIRQHSRSILKWA 978
            :..:|...| .|:.::.|.:.:...|.|...|.:       :::. :..||.......|.:||..
Human   324 IMPLELKTGKESNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVPANHLDKRELLKLR 388

  Fly   979 NQW---LKHG-SVDAVAEQDVLMPIPPEFDSFKNYREI-----------------------FVPL 1016
            ||.   |.|. |..|..::..|..:|...:..|..:..                       .|.|
Human   389 NQMAFSLFHRISKSATRQKTQLASLPQIIEEEKTCKYCSQIGNCALYSRAVEQQMDCSSVPIVML 453

  Fly  1017 MKLE------------------LLSTIE---RDYKINNKNTFSVSLINVETQDMCYRLVTRVNSK 1060
            .|:|                  |:.|:|   :|.|.|::|.:.:....:|....|...:.|:..
Human   454 PKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSCIGNLIRMEH- 517

  Fly  1061 PFGKFVLYTLYCCGMLKETF---------ANLL--ELKFVSGNVFDLTFEILKQDISEEKLKNI- 1113
                   ..:.|.|.....|         .||:  :...|||....| |.:.:..:.|..:..:
Human   518 -------VKIVCDGQYLHNFQCKHGAIPVTNLMAGDRVIVSGEERSL-FALSRGYVKEINMTTVT 574

  Fly  1114 ----KQLTARPVVDSLRVE-----------LGALSAVHQLRSSPLCRRI------LKPTQTVNEV 1157
                :.|:..|.....|::           ||.||.:  :.::.:.:::      .:..|.::.:
Human   575 CLLDRNLSVLPESTLFRLDQEEKNCDIDTPLGNLSKL--MENTFVSKKLRDLIIDFREPQFISYL 637

  Fly  1158 S--LPKQPFTFKGC--HKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTL 1218
            |  ||........|  ..||:.|...:    ::::  |....|||.|.|||||:..|..| ::.|
Human   638 SSVLPHDAKDTVACILKGLNKPQRQAM----KKVL--LSKDYTLIVGMPGTGKTTTICTL-VRIL 695

  Fly  1219 YGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHF 1283
            |     .....:|:.:::::|||:|       |..:.:.:...||.|..:|:....:.|:
Human   696 Y-----ACGFSVLLTSYTHSAVDNI-------LLKLAKFKIGFLRLGQIQKVHPAIQQFT----- 743

  Fly  1284 NKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPP 1348
                ||::.| ||                        ::.|..||:         :|.::||
Human   744 ----EQEICR-SK------------------------SIKSLALLE---------ELYNSQL--- 767

  Fly  1349 LTQREEFEISHMCVTRANIICTTLSSCVKLANYVDF----FDICIVDEATQCTEPWTLLPMRFGL 1409
                              |:.||   |:.: |:..|    ||.||||||:|.::|..|.|:.|.
Human   768 ------------------IVATT---CMGI-NHPIFSRKIFDFCIVDEASQISQPICLGPLFFS- 809

  Fly  1410 THMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMH 1474
            ...|||||.||||.:||:::|...|:|.|:|.|::::              .:.:.:|:.||||:
Human   810 RRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQN--------------KSAVVQLTVQYRMN 860

  Fly  1475 PEICRWPNQYFYE-------DQLINAECTAR-----------FA------------SPLIPYCVI 1509
            .:|....|:..||       |::.||....|           :|            .|..|.|.:
Human   861 SKIMSLSNKLTYEGKLECGSDKVANAVINLRHFKDVKLELEFYADYSDNPWLMGVFEPNNPVCFL 925

  Fly  1510 NLKYTCDSNGAQNKSISNNEEARFVAKLLTEMDKH--MPSKRFSYGLISPYQNQCYALSQVIPSH 1572
            |..........:...:||..||:.:..|.:...|.  .||   ..|:|:||:.|...::.::...
Human   926 NTDKVPAPEQVEKGGVSNVTEAKLIVFLTSIFVKAGCSPS---DIGIIAPYRQQLKIINDLLARS 987

  Fly  1573 MN-ITPQTVDSYQGLEKDVIIISNARTRGCG----FLTNYQRLNVALTRPRRCLVICGNFEDLKS 1632
            :. :...|||.|||.:|.::::|..|:...|    .|.:::|||||:||.:..|::.|....|..
Human   988 IGMVEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLKDWRRLNVAITRAKHKLILLGCVPSLNC 1052

  Fly  1633 VEMWRNLLDDARKRKVYFNL 1652
            ......||:.....|:..:|
Human  1053 YPPLEKLLNHLNSEKLIIDL 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	69/260 (27%)
		AAA_19	1194..1251	CDD:289986	18/56 (32%)
		YtxH	<1293..1347	CDD:295162	9/53 (17%)
		AAA_12	1435..1626	CDD:289832	54/227 (24%)
DNA2	XP_006717743.1	Dna2	101..312	CDD:285859	11/52 (21%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<291..427	CDD:294426	26/135 (19%)
		TIGR00376	501..1062	CDD:273041	155/676 (23%)
		P-loop_NTPase	655..905	CDD:304359	88/351 (25%)
		AAA_12	835..1047	CDD:289832	55/228 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810