DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and C05C10.2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001364625.1	Gene:	C05C10.2 / 174546	WormBaseID:	WBGene00007329	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1779	Identity:	335/1779 - (18%)
Similarity:	581/1779 - (32%)	Gaps:	617/1779 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 PTEFNLKQQIPNFGGKQDPGQE----------EEVLPSSSNLHLPKLTEVKQEIVKHTSEEIQNI 197
            ||.|:..:::.::   |.|...          .::.|::|      :.|.:..|:..|..:
Worm    20 PTHFDTWERLSDY---QKPSSSTTDDAYGKPVAKISPTAS------IDERETGIIGSTLRQ---- 71

  Fly   198 FGEPSDAILNSVLELNPYLYNKLTNKTANNEITRKKIHDGDCIELDTDTDRRSISE--------- 253
              :.:|:.......:|||      ::.....|::|..|        |::.|..:.|
Worm    72 --DSTDSDSTGSSNMNPY------DRLDKEVISKKNAH--------TNSYRNDVDELEGSLRTLG 120

  Fly   254 AQKAEDP-----SAEREVDDEEEYDESFAMSQAVIREMKAEMHVSDGEEDFLLTNGMGNLPEGSP 313
            .||...|     ||.:..........|...|:.|..|:||                    |:...
Worm   121 LQKVNAPTISSFSAWKSQSSALPAPSSSETSKIVKAEIKA--------------------PQQPM 165

  Fly   314 S-NQAYDDIVYVSDSDDDELYDKVADWSKLLSQKVVPD---VIEMSQTYPLE---NEHKDSDSDL 371
            | |..|.|::...:...: ::.|:...|::.::..:|.   ::...|.:..:   ..|...::.:
Worm   166 SLNPNYFDVMREMEKSMN-IFTKLFRGSQIRNKNDLPSGRHLVNYRQNHAFDFAAMSHIWKENKM 229

  Fly   372 DIGAKKPKR-----TL---RISSS----------SDEDSADEVIVHQTKQKGRRSKSKSPNDHVV 418
            :...|.|.|     ||   |:.:|          ..||....|..|             .|.|..
Worm   230 ENLPKLPHRANLVMTLPSSRVRNSKICAFYRVLEKKEDKYILVACH-------------VNIHGF 281

  Fly   419 RQADSTTPDL---PAVRKLSVSSI-------DSVYENKQTKLNSKLKSCLKSPTKTSVDNMENMT 473
            .:.|....::   ..::....||:       |.:...:.|:.|..:.:...|        :|:.:
Worm   282 HRGDLRFVEVNNRTVLKGFERSSVIGHLFLGDILTVTELTRCNETVSNVASS--------VEDAS 338

  Fly   474 ETKSCSNRQREQIVASRNEPTNICPQKIETNKTSTRKRFVSTTSRDELSTTSKEIKDAPKNNVEP 538
            ....|.....:.::..|:||.|: ..|...|..::   .|||  .:.:|.....:.:| |.|||.
Worm   339 PDAPCQWMASKVVLFPRHEPVNV-QFKFTCNGMAS---VVST--NEPMSVILNNLTEA-KTNVEY 396

  Fly   539 PKKMLRSRSKSCYIDRPVELDEHITKNEVPLKKKYESVDNSKEELIVTLEAPAMLTT----PTKS 599
            .....:|.|             :....|...||.||.:   :||:...:..|..|:|    ...:
Worm   397 TGIAFKSAS-------------YTVHTEDYTKKWYERI---QEEISNIMIYPKALSTIYQYEEYT 445

  Fly   600 KTQCVKKKATQTRGRRKTIHSRDEIRSLTAEA-----------EENKKISPAKQ----------- 642
            ....|:|:..:....::.:...|..|....:.           .|.:|..|.|.
Worm   446 PNFVVEKQEQEEHPYQQDLEDLDLYRQHEMQTNVFTKFFDIGKSEKRKFGPGKSISNCRHSDAID 510

  Fly   643 ----------------------TNEEIPIPTKSPLKRNA----RLL--NRSK----SCYMD---- 671
                                  .|..:|:||..||....    |:|  |:||    :|:|:
Worm   511 FAAMSYIWKNIRQQHLPKLPKLPNMVLPLPTSMPLDSEICAFYRVLVENKSKYILIACHMNVHGY 575

  Fly   672 ---------------------RLVISE---------TE--------DPAKKVIKDISPTKSDTTD 698
                                 |.||.:         ||        ..|.|:..|:|.:..:|.
Worm   576 HRGDLRFLEINESTKLYGFEGRSVIGQLFLGDIVAVTELARCNGHGSDAFKIPFDVSMSSQNTC- 639

  Fly   699 NVLNFVDVRQTRGPSVIEAPSLP----------KNR-GKLRGVSAEVKVKDKVLDRQRFIDYQAE 752
                      |...|.|..||.|          ||| ..::|....:.|:.|.:.       ..|
Worm   640 ----------TWMASKITLPSRPPPASVLFSFMKNRMAVVKGCDEPMNVEVKSIQ-------NVE 687

  Fly   753 MNAKWKQ---KPKDKKKEDEKLKECRREALKKLSEKPKENSHRSTTNKRKN------------PT 802
            .:..:|.   ||                      |||:.|.......|:::            |.
Worm   688 PDLIYKGTAFKP----------------------EKPELNFTEGFIKKKRHQIGSITLRIASYPN 730

  Fly   803 SVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPKQPPAIETFSQQLQAADKAVLHPQP 867
            |..|:.|     |....:|....|:                   .|..||
Worm   731 SFGTIYN-----FQESDIDNEHYKI-------------------GINAFS--------------- 756

  Fly   868 QCSRPVERKEAELARNQR-----TCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKVHCIE 927
                  |.|..|::.::|     ||:.:.|:..........|.:..  |:.::..|....:.|||
Worm   757 ------EEKFTEISLDEREKIVETCSLMGFSAANTIFNGRFDCRAF--KMEEIKKNGMTVMFCIE 813

  Fly   928 R-----------------VKGASSKVQGRKECI-------KLRLSSYRERREWIRRENKPVNDIR 968
            .                 :.|.:..|.|..|.:       .||:::...|
Worm   814 NPTSQPTLGLWCAGNRIVIGGPNGDVNGAIETVIDDPDIGYLRIAARLSR--------------- 863

  Fly   969 QHSRSILKWANQWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINN 1033
                                         .||.:| |||...|.||                 :.
Worm   864 -----------------------------DIPKKF-SFKGDGEFFV-----------------SQ 881

  Fly  1034 KNTFSVSLIN---VETQDM-CYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVF 1094
            :..|...:::   .:|.|. |.           |:.::.|||....|:....:
Worm   882 REVFENEILDDGYFKTLDPGCN-----------GRRIIETLYGGKPLERVVVD------------ 923

  Fly  1095 DLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQTVNEVSL 1159
                   |:|.|.|::  :.||            .|..|.:.:.::|.     .|...|..:...
Worm   924 -------KRDSSIERM--MSQL------------FGVGSGISEHKTSG-----KKSEDTPTQFYF 962

  Fly  1160 PKQPFTFKGCHKLNEHQENIVLHTYQ----RIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYG 1220
            |..|             |.:.|:.||    :::.|..| |.:...|.|.|||..|....|: ||
Worm   963 PSTP-------------EPLALNKYQCEYVQMLLDGNP-LIIGSSPFGCGKSMTIITAALE-LY- 1011

  Fly  1221 NAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRF-------GMHEKMSHYSRPFS 1278
              ....:||.|:...||.|..:::.:...|. :...|....|:|       ..:|..|:......
Worm  1012 --KLKKNRKQLLITQSNYASVNLIDIAQRVC-LSGDDDLKDLKFVRFVSEKNWNELPSNCRTDSD 1073

  Fly  1279 LEAHFNKA-KEQKLQRVSKENAEILKKQHNDLKDEIQQLKE--KTNLTSTYLL-QQLQQKEKKLQ 1339
            :....||. |:..:.|:...|...||..|     .:|.:..  |.:|.:..|. ..:.|...||.
Worm  1074 MPYLMNKLFKDWAMGRIDLTNLTCLKTHH-----YVQMVSHIIKNDLVNPMLFGDHIAQIYDKLS 1133

  Fly  1340 LISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDFFDICIV--DEATQCTEPWTL 1402
            ...::.....|..|.|    ..:.:.:::..|..|...|.|.:.  |:|.|  |||:|..| .||
Worm  1134 ADFSRAPHAQTLVEAF----FMIYKPDLVMVTADSAKGLLNILR--DVCAVQIDEASQLAE-CTL 1191

  Fly  1403 LPM--RFGLTHMVLVGDMQQLPAVV---LSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHT 1462
            |.:  .|......|:||:.|||...   |..|..|||:.|:|    :|:::             .
Worm  1192 LGLLKSFNNASFGLIGDIHQLPPYCEEGLEGKLKDFGIGNTM----ERAIK-------------E 1239

  Fly  1463 KLFKLST---QYRMHPEICRWPNQYFYEDQLINAE--------CTAR---FASPLIPYCVINLKY 1513
            |:|.:.|   .||.||:.....::.||:..|::..        .|.|   :.:|..|...:|
Worm  1240 KMFPVCTLRNVYRCHPKTTELLSELFYDGALVSGVSELARSDFMTKRDDFWPNPKFPMMFVN--- 1301

  Fly  1514 TCDSNGAQNK---SISNNEEARFVAKLLTEM--DKHMPSKRFSYGLISPYQNQCYALSQVIPSHM 1573
               :.||..|   |.||:.|...|.:::..:  |...|......|:||.|..|    :.::..|:
Worm  1302 ---NTGASTKMGTSTSNSSEKSIVGEIVQNLINDPRNPVNPSDIGVISFYSAQ----TSILTEHL 1359

  Fly  1574 ---NITPQTVDSYQGLEKDVIIISNARTRGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEM 1635
               .:...|||::||.||::||:.:...|...|:....|||||::|.::..:|.|:.:.|:....
Worm  1360 RGSGVKCGTVDAFQGSEKEIIIMCSTNERISDFMQLSNRLNVAMSRAKQVTIIIGHLDGLRRANY 1424

  Fly  1636 WRNLLDDARKRKVYFNLDRDDVND 1659
            |..:::     |:..|.:..:.||
Worm  1425 WSTIVN-----KIEQNGNLVNAND 1443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	69/278 (25%)
		AAA_19	1194..1251	CDD:289986	16/56 (29%)
		YtxH	<1293..1347	CDD:295162	12/56 (21%)
		AAA_12	1435..1626	CDD:289832	52/212 (25%)
C05C10.2	NP_001364625.1	DNA2	<941..1442	CDD:224037	136/568 (24%)
C05C10.2	NP_001364625.1	SF1_C_Upf1	1253..1433	CDD:350195	48/194 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910