DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Mov10

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001156912.1	Gene:	Mov10 / 17454	MGIID:	97054	Length:	1077	Species:	Mus musculus

Alignment Length:	807	Identity:	190/807 - (23%)
Similarity:	304/807 - (37%)	Gaps:	246/807 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   936 VQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMPIP 1000
            ::.|...:||||..:.|       |.:..:|||               |..:|:|         |
Mouse   405 LKSRNYEVKLRLLLHLE-------ELQMEHDIR---------------HYDLDSV---------P 438

  Fly  1001 PEFDSF-KNYREIFVPLMKLELLSTIE-RDYKINNKNTFSVSLINVETQD---MCYR-LVTRVNS 1059
            ..:|.. :|.|     |:.||:....| |...:...:.|  :|::.|||.   :.|: .|.:|.
Mouse   439 MTWDPVDQNPR-----LLTLEVPGVAESRPSVLRGDHLF--ALLSSETQQDDPVTYKGFVHKVE- 495

  Fly  1060 KPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDS 1124
                         ...:|.:|:..|..:||.|..|.:.|...:|                    .
Mouse   496 -------------LDRVKLSFSTSLLSRFVDGLTFKVNFTFNRQ--------------------P 527

  Fly  1125 LRVELGALSAVHQLRSSPLCRRILKPTQTVNEVSLPKQPFTFKGCHK-LNEHQENIVLHTYQRII 1188
            |||:..||....:....|:    |.|..: ..|||......||...: |..:.|.  |...:.|:
Mouse   528 LRVQHRALELTGRWVLWPM----LFPVAS-RGVSLLPSDVKFKLYDRSLESNPEQ--LQAMKHIV 585

  Fly  1189 -DDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDR-KILICAHSNTAVDHIVGLLGSVL 1251
             ...:|:..:|.|||||||:..:.|...|.:     |.|.: .||.||.||:..|    ||...|
Mouse   586 RGTTRPAPYIIFGPPGTGKTVTLVEAIKQVV-----KHLPKAHILACAPSNSGAD----LLCQRL 641

  Fly  1252 RVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQL 1316
            ||      ||              |.|:         .:|...|::    ::....|:|......
Mouse   642 RV------HL--------------PSSI---------YRLLAPSRD----IRMVPEDIKTCCNWD 673

  Fly  1317 KEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANY 1381
            .:|.        :.:...:|.||                        :..::.|||.:..:|.:.
Mouse   674 AKKG--------EYVYPAKKHLQ------------------------QYRVLITTLITASRLVSA 706

  Fly  1382 ---VDFFDICIVDEATQCTEPWTLLPMRFGLT----------HMVLVGDMQQLPAVVLSKKAIDF 1433
               :|.|....:|||..|.||.:|:.:. ||.          .:||.||.:||..|:.|..|:..
Mouse   707 QFPIDHFTHIFIDEAGHCMEPESLVAIA-GLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKH 770

  Fly  1434 GLSNSMFDRIQRSLQTQLDKPGSYHLMHTK---------LFKLSTQYRMHPEICRWPNQYFYEDQ 1489
            ||..|:.:|:.           :|:.::.|         :.||...||.||.|...|||.:|:.:
Mouse   771 GLGYSLLERLL-----------AYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGE 824

  Fly  1490 L------INAECTARFAS------PLIPYCVINLKYTCDSNGAQNKSISNNEEARFVAKLLTEM- 1541
            |      ::.|...|:..      |:|.:.|:..    |.....:.|..|.|||..|...|.::
Mouse   825 LQACADVVDRERFCRWEGLPQQGFPIIFHGVMGK----DEREGNSPSFFNPEEAATVTSYLKQLL 885

  Fly  1542 ------DKHMPSKRFSYGLISPYQNQC----YALSQV------IPSHMNITPQTVDSYQGLEKDV 1590
                  .|...|.| :.|:||||:.|.    |.::::      :....::...:|:.:||.|:.|
Mouse   886 APSSKKGKARLSPR-NVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSV 949

  Fly  1591 IIISNARTR----------GCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARK 1645
            |:||..|:.          ..|||.|.:|.|||:||.:..|::.||...|.....|:..|:..::
Mouse   950 ILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKE 1014

  Fly  1646 RKVY------FNLDRDDVNDLDRSLIK 1666
            ...|      ..||.....||.:.|.|
Mouse  1015 NGGYTGCPFPAKLDLQQGQDLLQGLSK 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	63/272 (23%)
		AAA_19	1194..1251	CDD:289986	21/57 (37%)
		YtxH	<1293..1347	CDD:295162	7/53 (13%)
		AAA_12	1435..1626	CDD:289832	60/238 (25%)
Mov10	NP_001156912.1	AAA_11	574..765	CDD:289831	62/267 (23%)
		P-loop_NTPase	574..>761	CDD:304359	61/263 (23%)
		AAA_12	772..996	CDD:289832	61/239 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810