DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and smg-2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_490829.1	Gene:	smg-2 / 171696	WormBaseID:	WBGene00004880	Length:	1069	Species:	Caenorhabditis elegans

Alignment Length:	817	Identity:	205/817 - (25%)
Similarity:	337/817 - (41%)	Gaps:	227/817 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   956 WIRRENKPVNDIRQHSRSI-----LKWANQWLKH--GSVDAVAEQDVLMP--------IPPEFDS 1005
            ||  .|.|..:....:|.|     ::....|..|  .:||     |:..|        :...:..
Worm   213 WI--VNVPSEEQVARARKITATQAVRMEELWRDHPEATVD-----DLNKPGLDREPDHVQLRYVD 270

  Fly  1006 FKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTL 1070
            ..:|.::|.||:.:|    .|.|.::....:.:|..:..| |.:...::.         |.....
Worm   271 AHHYSKVFRPLVAIE----AEYDRRVKESASQAVGTVRWE-QGLRQSVLA---------FFHLPQ 321

  Fly  1071 YCCGMLKETFANLLELKFVS----------GNVF--------DLTFEI---LKQDISEEKLKNIK 1114
            :..|::|....:.|.||...          |:||        ::..||   :.:.:.|.::
Worm   322 FADGVMKLAKGDELRLKHSQTVDGSEWTKIGSVFKIPDNHGDEVGIEIRGAVDKSVMESRI---- 382

  Fly  1115 QLTARPVVDSLRVE-----LGALSAVHQLRSSPLCRRIL-KPTQTVN-EVSLPKQPFTFKGCHKL 1172
            ..|...|.::...|     |.||....:..|..|.:::| .|.:.:. :..||:: .:..|..:|
Worm   383 MFTVDVVWNATTFERQYKALAALLNDSKAISPYLYQKLLGHPAEEMMLKFDLPRR-LSVAGLPEL 446

  Fly  1173 NEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSN 1237
            |..|...|.....|       .|:||||||||||:.|.:.:    :|....|| :..:|:|:.||
Worm   447 NSSQMQAVKQVLTR-------PLSLIQGPPGTGKTVVSATI----VYHLVQKT-EGNVLVCSPSN 499

  Fly  1238 TAVDHI------VGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNK----AKEQKLQ 1292
            .||||:      .||  .|:|:..|.:.|          |..:.|:....|..|    |:.|||.
Worm   500 IAVDHLAEKIHKTGL--KVVRLCARSREH----------SETTVPYLTLQHQLKVMGGAELQKLI 552

  Fly  1293 RVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEI 1357
            :               ||||..:|:.|.:      |:.:|.|..|
Worm   553 Q---------------LKDEAGELEFKDD------LRYMQLKRVK-------------------- 576

  Fly  1358 SHMCVTRANIICTTLSSCV-----KLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGD 1417
            .|..:..|::||.|.||..     |:....     .::||:||.|||..|:.:..|:..:|||||
Worm   577 EHELLAAADVICCTCSSAADARLSKIRTRT-----VLIDESTQATEPEILVSIMRGVRQLVLVGD 636

  Fly  1418 MQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPN 1482
            ..||..||:.|||...|||.|:|:|:.              |:..:.|:|..||||||.:..:|:
Worm   637 HCQLGPVVICKKAAIAGLSQSLFERLV--------------LLGIRPFRLQVQYRMHPVLSEFPS 687

  Fly  1483 QYFYEDQLINA------ECTA---RFASPLIP----YCVINLKYTCDSNGAQNKSIS-----NNE 1529
            ..||:..|.|.      ..|.   .:..|..|    :|          :|::..|.|     |..
Worm   688 NVFYDGSLQNGVTENDRHMTGVDWHWPKPNKPAFFWHC----------SGSEELSASGTSFLNRT 742

  Fly  1530 EARFVAKLLTEMDK-----HMPSKRFSYGLISPYQNQCYALSQVIPSHM------------NITP 1577
            ||..|.||::::.|     |      ..|:|:||:.|    ...|.::|            |:..
Worm   743 EAANVEKLVSKLIKAGVQPH------QIGVITPYEGQ----RSFIVNYMHTQGTLNSKLYENVEI 797

  Fly  1578 QTVDSYQGLEKDVIIISNARTR---GCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNL 1639
            .:||::||.|||.||::..|:.   |.|||::.:|||||:||.:..||:.||.:.|...::|..|
Worm   798 ASVDAFQGREKDYIIVTCVRSNDILGIGFLSDPRRLNVAITRAKYGLVLVGNAKVLARHDLWHEL 862

  Fly  1640 LDDARKRKVYFNLDRDDVNDLDRSLIKKMMVNTINLI 1676
            ::..:.:::.:....:.:..|:.:| .|..:.|.|.|
Worm   863 INHYKSKEMLYEGPINALKPLNLAL-PKATIRTKNNI 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	78/271 (29%)
		AAA_19	1194..1251	CDD:289986	25/62 (40%)
		YtxH	<1293..1347	CDD:295162	10/53 (19%)
		AAA_12	1435..1626	CDD:289832	65/228 (29%)
smg-2	NP_490829.1	UPF1_Zn_bind	93..243	CDD:286500	7/31 (23%)
		DNA2	117..874	CDD:224037	199/790 (25%)
		AAA_19	452..>509	CDD:289986	25/68 (37%)
		AAA_12	654..851	CDD:289832	67/230 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820