DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and AgaP_AGAP006235

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_316302.4	Gene:	AgaP_AGAP006235 / 1276895	VectorBaseID:	AGAP006235	Length:	1049	Species:	Anopheles gambiae

Alignment Length:	1102	Identity:	225/1102 - (20%)
Similarity:	404/1102 - (36%)	Gaps:	331/1102 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 DKKKEDEKLK---ECRREALKKLSEKPKENSHRSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPA 824
            :|.:||..:|   :...::..:..:..::::....|:.|:...::....|...|.::........
Mosquito    18 NKDEEDFVVKIPSQTSADSFDEAGDDKEDDAQGPGTSVRELLENLKFTLNDVGGSYVDSIKSAGT 82

  Fly   825 PKLAKTDNAKPPPKK-----PVPKQPPAIETFSQQLQAADKAVLHPQPQCSRPVERKEAELARNQ 884
            .:.||.:..|.||.|     |:.|....:|..:..: .||..|            :||..||
Mosquito    83 DRTAKFELPKGPPGKYVQTIPLTKLANILENETLSM-FADICV------------QKEEFLA--- 131

  Fly   885 RTCNKVTFAE---------------------------------------MELYHQKAEDSKKLQK 910
             |..|.|:.|                                       ::.:.|.||..||.:|
Mosquito   132 -TLAKKTYGEELLLVLMKIMNKLATLPLYETVRQLFGVLLEQAHFWEQLLKYFQQPAEGEKKKKK 195

  Fly   911 KLR----KVHFND----------DVKVH------------CIERVKGA--------------SSK 935
            |.:    .|..||          :.|.|            |.:..|||              :..
Mosquito   196 KSKIIRPTVARNDMMEVLLKFLLEAKRHVAPPLPQQAVEFCEKLRKGAPPDDKAQVELLQELTRD 260

  Fly   936 VQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWANQWLKHGSVDA---VAEQDVLM 997
            .|.::|....::|.|...||.......|:| ::|   :|:|...|.::| .::.   :.::|.|:
Mosquito   261 TQTQQEQATKQISIYPTIRELKDGAGPPIN-LKQ---NIVKGKYQSVQH-YLEVHLNLLKEDFLI 320

  Fly   998 PIPPEFDSFKNYRE--------------IFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQ- 1047
            |:....:.::.:.:              :..| :||.|.||:       |:.|....||.|:..
Mosquito   321 PLRTGMEKYRKHVDTKGSGKSFVGENVRVHYP-VKLLLPSTV-------NRRTAKEQLILVDLDP 377

  Fly  1048 --------DMCYRLVTRVNSKPF--GKFVLYTLYCCG-----MLKETFANLLELKFVSGNVFDLT 1097
                    ...|:.:...|:|.|  |..|   |:|.|     ::....:|....:.::|.::
Mosquito   378 TERGYSNLSARYKRLALPNTKRFMNGSMV---LFCDGPELNELVVAVISNRDAAQLLNGYIY--- 436

  Fly  1098 FEILKQDISEE-------KLKNIKQLTARPVVDSLRVEL------GALSAVHQLRSS--PLCRRI 1147
            .|:::.:...|       ...:...|..||:: .:..|:      ...:|:.:||..  ||...|
Mosquito   437 VELIRMEKQREGGQDQPMGADHGMNLFNRPLL-MIESEIFFEPYHQTFNALSRLREDNFPLKSYI 500

  Fly  1148 LKPTQTVNEVSLPKQ--P----------FTFKGCH----KLNEHQENIV-----LHTYQRIIDDL 1191
            :       :|:||.:  |          |.:.|..    |.:|.....:     |:..|  .|..
Mosquito   501 V-------DVTLPGKCLPGYLYQGGGHLFNYAGIQFDLKKPDEWPTEALTAAAGLNVSQ--FDAY 556

  Fly  1192 QPSLT----LIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSNTAVDH----IVGLLG 1248
            :.:||    ||||||||||: .|....::||..|..:.:   :|||. :|.|:|.    :.....
Mosquito   557 RMALTSRFSLIQGPPGTGKT-FIGLRIVETLLANTGEQI---LLICL-TNHALDQFLCGVTRFTD 616

  Fly  1249 SVLRVMNRDQFHLL------------RFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEI 1301
            |::|:..:.:..||            |.....::|:|:           ||::.|:.|  |..:.
Mosquito   617 SIVRMGGQSKHPLLDAYNVKQLQEDERIDRRLRISYYN-----------AKQEYLKLV--ERFDA 668

  Fly  1302 LKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRA- 1365
            |:::...|....|.::|        .:::|....::|..:|...:..|.|  .|.:..|..|.|
Mosquito   669 LQQEQETLDGMTQAMQE--------CMEELLDASRRLSELSQLNTLKLIQ--GFRVVAMTTTFAA 723

  Fly  1366 -NIICTTLSSCVKLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQL----PAVV 1425
             |   .||...::.       .|.:::||.:..|...:..:.......:|:||.:||    ...|
Mosquito   724 RN---RTLLELLRT-------PIVVIEEAAEVLEAHIVAALTRHTAQCILIGDHKQLRPTTSTYV 778

  Fly  1426 LSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLST---QYRMHPEICRWPNQYFYE 1487
            ||.:   :.:..|:|:|                 |....|.::|   |:||.||:........|
Mosquito   779 LSSR---YRMDLSLFER-----------------MINNRFSVATMTVQHRMRPEMADLLRPLIY- 822

  Fly  1488 DQLINAECTARFASPLIPYCVINLKY---------------TCDSNGAQNKSISNNEEARFVAKL 1537
            ..|.:||..|  ..|.:...:.|:.:               :...:|...||..|..|.||:..|
Mosquito   823 PVLDDAETVA--TRPNVAGMMRNMFFLTHNYPEGGGPANDSSVGDDGGDEKSKKNIFECRFLLGL 885

  Fly  1538 ---LTEMDKHMPSKRFSYGLISPYQNQCYALSQVI------PSHMNITPQTVDSYQGLEKDVIII 1593
               |.....:.|.   ...:::.|..|   :.|.:      ||...:....:|:|||.|..::::
Mosquito   886 CEYLLAQGTYTPE---DIVILTAYNGQ---MLQFVAEKKNRPSLHGVRIAVIDNYQGEESKIVLL 944

  Fly  1594 S--------NARTRGCGFLTNYQRLNVALTRPRRCLVICGNFEDL-KSVEMWRNLLDDARKR 1646
            |        |..|...|||.:..|:.|||:|.|..|.|.||...| |..:.|..:....|::
Mosquito   945 SLVRSGTGGNGGTDTIGFLAHENRICVALSRAREGLYIVGNMTLLAKCSKTWHRIEGKLREQ 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	66/287 (23%)
		AAA_19	1194..1251	CDD:289986	23/64 (36%)
		YtxH	<1293..1347	CDD:295162	9/53 (17%)
		AAA_12	1435..1626	CDD:289832	52/225 (23%)
AgaP_AGAP006235	XP_316302.4	AAA_11	547..774	CDD:289831	62/266 (23%)
		AAA_19	562..>607	CDD:289986	20/49 (41%)
		UvrD_C_2	785..986	CDD:304668	53/226 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810