DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and AgaP_AGAP005926

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_315956.4	Gene:	AgaP_AGAP005926 / 1276593	VectorBaseID:	AGAP005926	Length:	1738	Species:	Anopheles gambiae

Alignment Length:	1902	Identity:	469/1902 - (24%)
Similarity:	775/1902 - (40%)	Gaps:	470/1902 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GRHSRCRIILGGQYQFVSREHANIIVSEKGVEVESLNPLNGLFINGGKLGDKI--NRLAVAEGST 88
            |:.:.|: ...|:|..|||.|..:.:.:....:...:...|.|:||.:: ||.  .|:.:.||..
Mosquito    43 GKDANCQ-FKPGKYFLVSRNHCMVQIVDGKPTITDCHSRRGTFVNGDRI-DKFQPGRIELKEGDL 105

  Fly    89 ISLGVTGVNLNEITGIHAIFILKKKEPVV---EEIVLSSDDDDTT--------PLPAVRCPTGTQ 142
            :.:......:.:....|...:..:....:   |.:|:|.|:.:..        |.|.:..|:...
Mosquito   106 VGIAHKNEEIQQYFKFHDEVLRYRVCRTIGKDEAVVISDDEQEEAVDVKCAILPEPDLDIPSTAS 170

  Fly   143 PTEFNLKQQ----IPNFGGKQDPGQEEEVLPSSSNLHLPKLTEVKQEIVKHTSEEIQNIFGEPSD 203
            .::....|.    :.| |.::....:    |..|.|.|..:..:.:|:::.:|.|.|      .|
Mosquito   171 SSQSEASQSDTEPVEN-GSERSASPQ----PGPSGLQLSAVVSIPEELMRKSSFERQ------YD 224

  Fly   204 AILNSVLELNPYLYNKLTNKTANNEITRKKIHDGDCIELDTDTDRRSISEAQKAEDPSAEREVDD 268
            .::....:|||                     ||    .::||:.........|.|.|....:.|
Mosquito   225 DMMLCASKLNP---------------------DG----YESDTEPEPCVVQPVAYDTSDVIVLSD 264

  Fly   269 EEEY-DESFAMSQAVIREMKAEMHVSDGEEDFLLTNGMGNLPEGSPSNQAYDDIVYVSDSDDDEL 332
            ::|| |..:  ||.||.|::.|:     |:|..|.    .||:             :.:.::|
Mosquito   265 DDEYIDVQY--SQMVIEEVQQEL-----EDDVELV----ELPD-------------LGEEEED-- 303

  Fly   333 YDKVADWSKLLSQKVVPDVIEMSQTYPLENEHKDSDSDLDIGAKKPKRTLRISSSSDEDSADEVI 397
                   :.|.:.|:.||| :.::.|...             ||:.|.....|.....|:.::..
Mosquito   304 -------TSLWALKLKPDV-DATRRYKKR-------------AKEAKEEKEASKRERPDAFEKQN 347

  Fly   398 VHQTKQKGRRSKS--KSPNDHVVRQADSTTPDLPAVRKLSVSSIDSVYENKQTK-LNSKLKSCLK 459
            .|....|..||.|  .|..::|..|.:....:......|..:|.|:.:::.:|| :::|..|  :
Mosquito   348 HHHHHHKKHRSSSSRSSEEENVAVQREDAGKESSLKVVLKRNSTDAKWDDIETKTVDAKKPS--R 410

  Fly   460 SPTKTSVDNMENMTETKSCSNRQREQIVASRNEPTNICPQKIETNKTSTRKRFVSTTSRDELSTT 524
            ..|::|.|:..:..:.|....|..|.|.::.:......|...:.:|..|......||:....|..
Mosquito   411 HTTESSKDSKRDAGDAKKLHRRTTEPIASTSSPAVEPIPSTSKHSKEPTPSSSRHTTNGPSTSAA 475

  Fly   525 SKEIKDAPKNNVEPPKKMLRSRSKSCYIDRPVELDEHITKNEVP--LKKKYESVDNSKEELIVTL 587
            ....:..|..:.:..|:...|.|:  :.:.||......|....|  .::.||
Mosquito   476 RHTHEPTPSTSSKHTKEPTPSTSR--HTNGPVASTSRHTAEPTPSTSRQSYE------------- 525

  Fly   588 EAPAMLTTPTKSKTQCVKKKATQTRGRRKTIHSRDEIRSLTAEAEENKKISPAKQTNEEIPIPTK 652
              ||   ||:.||                   .||.:    .:.|.|:   ||.....:.|...|
Mosquito   526 --PA---TPSTSK-------------------HRDSV----TDPERNR---PALDDKTKKPPQQK 559

  Fly   653 SPLKRNARLLNRSKSCYMDRLVISETE-------------------DPAKKVI-------KDISP 691
            .|.....||.||..|      |.:.||                   .|:|:|.       :...|
Mosquito   560 QPEDEPNRLKNRRHS------VANWTEIGPHRPSGTIEIAMPEKPKPPSKEVAAGPLWMQQAAKP 618

  Fly   692 TKS--DTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRG-----------VSAEVKVKDKVLDR 743
            ..:  :::.|.        :..|....|.|.||:..|.||           :..::|.:..|.||
Mosquito   619 AVAGENSSSNA--------SAAPEESTAASAPKSNLKRRGSVSSVGEVQAMIQKKLKRRYSVSDR 675

  Fly   744 QRFIDYQAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEKPKENSHRSTTN-------KRKNP 801
            ..| |:|..           |..:|:  ||.|:..|.:::||.|:...:....       .||..
Mosquito   676 NVF-DFQPV-----------KVSKDQ--KEQRKSRLMQINEKKKQQERQGPVMLFEPQPLGRKTG 726

  Fly   802 TSVPTVQNT--NRGGFLTKGVDGPAPKLAKTDNAKPP---------------------------- 836
            |:.|.|:.|  |||.|||..|  |.|..::..:...|
Mosquito   727 TTKPKVKFTPNNRGSFLTAPV--PLPSTSRAPSTSRPAATDESIVCTQSTTLEQLPTANGVEEEV 789

  Fly   837 ----PKK--------------PVP------KQPPAIET-FSQQLQAADKAVL-HPQ-PQCSRPVE 874
                |||              |||      |||.|..: .|..::......| .|| |..|..:.
Mosquito   790 IDMRPKKLTFQSVARVSNVDRPVPSGSGLNKQPLATSSNRSTNMEPPPPVTLAKPQHPSTSGGIS 854

  Fly   875 RKEAE------------------LARNQRTCNKVTFAEMELYHQKAEDSKKL---QKKLRKVHFN 918
            ...:.                  .:.|..|.:..|.|      ..|..|:::   |.|:|
Mosquito   855 NSSSNSHSSSTTTTTSTSSSNSASSSNTATTSATTAA------PTASTSQRVLPPQVKIR----- 908

  Fly   919 DDVKVHCIERVKGASSKVQGR----KECIKLRLSSYRER--------------REWIRRENKPVN 965
               |...::.:..:..|..|.    |:.:.:||...:.|              .:.:.....|..
Mosquito   909 ---KKQPLQGILKSYDKPNGENPAPKKSVTIRLELNKTRYIENCLDKSESPPPEKELPEPKLPQK 970

  Fly   966 DIRQH--------SRSILKWANQWLKHGSVDAV-----AEQDVLMPIPPEFDSFKNYREIFVPLM 1017
            :|::.        ...:|:|..:||:....:.:     |.:..|:|....:||::::|...:|.:
Mosquito   971 EIQEQILWQELDLLAEVLEWPTKWLQQQESELLANGPFASEGKLLPKLDNYDSYESFRNFHLPFL 1035

  Fly  1018 KLELLSTIERDYKINNK--NTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETF 1080
            |.||...|....|:...  ....|::...|..::| :|..:|.....|| ..:.|:..|:::  :
Mosquito  1036 KRELWQEIYTCAKVAKSFLTLHDVTVGKAEHVELC-KLFCKVRINTHGK-DFFPLFDFGIVE--Y 1096

  Fly  1081 ANLLELK---FVS----------------------GNVFDLTFEILKQDISEEKLKNIKQLTARP 1120
            .:||..|   |||                      |..|.||.....:::  |.|::.:....||
Mosquito  1097 HSLLGHKTSLFVSVRAQNKDDSVPLRDSNGVQQQPGLAFVLTLYAAGREL--EGLRSGRNFVYRP 1159

  Fly  1121 VVDSLRVEL--GALSAVHQLRSSPLCRRILKPTQT---VNEVS--LPKQPFTFKGCHKLNEHQEN 1178
            :.   ||.|  ...:|:..|..|||...|:.|...   :.|:.  |.:||          |.:.|
Mosquito  1160 LA---RVHLYMRRCNAISLLEHSPLLPNIICPVTNRAKLEEIDRRLQQQP----------EMRTN 1211

  Fly  1179 IVLH------------TYQRIIDDLQ----PSLTLIQGPPGTGKSRVISELCLQTL-YGNAAKTL 1226
            :..|            ....::|:.|    |:::||.|||||||||||..|.|:.: .|:.:|..
Mosquito  1212 VARHMEAGALNPGQMEIVSAVLDECQCWEEPTISLIHGPPGTGKSRVIGNLVLELMRLGHKSKER 1276

  Fly  1227 DRKILICAHSNTAVDHIV-GLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQK 1290
            .| :|:||.||||||.|| .|:....|....::|.|:|.|...|:.....|..::    |..:::
Mosquito  1277 MR-VLVCASSNTAVDVIVKNLMKLQQRKAANERFKLVRTGTRSKVDQECAPVFID----KLVQEE 1336

  Fly  1291 LQRVSK--------ENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSP 1347
            :.|.::        .:.:.::::.|.|.:.|:..:.:.:...:..::.|:..::||..:...|:|
Mosquito  1337 VNRQNRVPDARKNDGSLQNIERERNVLANRIKMAQAELSSGRSVNMEMLKVMKRKLHSLEEVLNP 1401

  Fly  1348 PLTQ--------REEFEI-SHMCVTR-ANIICTTLSSCVKLANYVD--FFDICIVDEATQCTEPW 1400
            ..|.        |::.|| :.:|:.: |:|:||||.||..||:|..  .|.:||:||||||||..
Mosquito  1402 GGTSSASATTDGRKKQEIKARICILQGADIVCTTLGSCSTLASYCTNLRFSVCIIDEATQCTELC 1466

  Fly  1401 TLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLF 1465
            :|||:::.|:.||||||:.||||.||.::.||.|...|:|.|:.:|......:|....|   |:.
Mosquito  1467 SLLPLQYHLSKMVLVGDINQLPATVLDQQCIDAGFRASLFSRLYQSYAGAGGQPPEDGL---KML 1528

  Fly  1466 KLSTQYRMHPEICRWPNQYFYEDQLINAECT--ARFASPLIPYCVINLKYTCDSNGAQNKSISNN 1528
            |  |||||||:||.|||:|||..||.||.||  .|...||.||.||:|.|..:...||.: |.|.
Mosquito  1529 K--TQYRMHPKICHWPNRYFYGGQLKNATCTEAMRKTIPLKPYMVISLSYDQELTQAQYE-IYNK 1590

  Fly  1529 EEARFVAKLLTEM----DKHMPSKRFSYGLISPYQNQCYALSQVIPSHM--NITPQTVDSYQGLE 1587
            :|..||.:|:.::    |||.     |:.:|:||......:.|.:.|..  .:...::||.||.|
Mosquito  1591 DEILFVVELMKQVVRCCDKHA-----SFAIITPYARHKEEMIQSLRSTQLKRVEVHSIDSVQGKE 1650

  Fly  1588 KDVIIISNARTRGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFNL 1652
            .||:|||.||:.|.|||.|.:|:||||||.|:|||:||||..||...:|.:||:||.|||||::|
Mosquito  1651 FDVVIISLARSNGAGFLNNPERINVALTRARQCLVLCGNFGSLKHKTVWSSLLEDAEKRKVYYHL 1715

  Fly  1653 DRDDVNDLDRSLIKKMM 1669
            :..|.....:.::|.:|
Mosquito  1716 EEHDAQVDGQKMVKNIM 1732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017	17/71 (24%)
		FHA	<10..101	CDD:224630	17/76 (22%)
		AAA_11	1171..1428	CDD:289831	96/294 (33%)
		AAA_19	1194..1251	CDD:289986	30/58 (52%)
		YtxH	<1293..1347	CDD:295162	8/61 (13%)
		AAA_12	1435..1626	CDD:289832	84/198 (42%)
AgaP_AGAP005926	XP_315956.4	FHA	<26..115	CDD:224630	17/73 (23%)
		FHA	39..108	CDD:278899	17/66 (26%)
		PHA03193	<435..568	CDD:177555	33/178 (19%)
		AAA_11	1221..1492	CDD:289831	91/275 (33%)
		AAA_19	1244..>1296	CDD:289986	29/52 (56%)
		AAA_12	1504..1689	CDD:289832	84/195 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	136	1.000	Domainoid score	I10064
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	343	1.000	Inparanoid score	I4600
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	1	1.000	-	-		oto107632
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X15329
TreeFam	1	0.960	-	-
	11	10.930