DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and AgaP_AGAP006939

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_308817.4	Gene:	AgaP_AGAP006939 / 1270145	VectorBaseID:	AGAP006939	Length:	1223	Species:	Anopheles gambiae

Alignment Length:	1492	Identity:	285/1492 - (19%)
Similarity:	488/1492 - (32%)	Gaps:	483/1492 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 KDSDSDLDIGAKKPKRTLRISSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPDLP 429
            |.||..|.: |::.|:........||:| .|:.....||      :..|.|     ...||..:.
Mosquito    15 KSSDQQLSL-AERIKQCEEKLQQEDEES-KEIKAEIVKQ------AMEPTD-----CFQTTGTIT 66

  Fly   430 AVRKLSVSSIDSVY-------EN----KQTKLNSKLKSCLKSPTKTSVDNMENMTETK------S 477
            .| |.....||.:|       :|    |..:.|:||:......|    |.:.....||      .
Mosquito    67 EV-KADYFIIDGIYFVPRAMLKNTEAAKHVEENTKLQFLANRKT----DPVSGEVSTKVVKVLSV 126

  Fly   478 CSNRQREQIVASRNEPTNICPQKIETNKTST-----RKRFVSTT---SRDELSTTSKEIKDAPKN 534
            ..|.......|:..|...   |..:|..|.|     |:|...|.   .||.| |...:..|....
Mosquito   127 VDNVWNHGAAAAEEEDWT---QPADTASTVTYFKKNRRREPGTVIGKDRDIL-TVETDAGDPISV 187

  Fly   535 NVEPPKKMLRSRSKSCYIDRPVELDEHIT--------------KNEVPLKKKYESVDNSK----E 581
            |::        ::...::.   .|.:::|              |.||   .:.||::.|:    .
Mosquito   188 NID--------KTSMTFVP---ALGDYVTLACMVQMDGKFVDFKGEV---LEVESIEPSRIVNGT 238

  Fly   582 ELIVTLEAP-AMLTTPTKSKTQCVKKKATQTR-GRRKTIHSRDEIRSLTAEAEENKKI------- 637
            .:|:.||.. ..:.|.|......:.:..|..| |:...:..|         |.|||.:
Mosquito   239 GVIIALEEDGGEIRTTTNGTVIFMVETLTDYRPGKGDRVEFR---------AVENKHVRLRCINL 294

  Fly   638 ---------------SPAKQTNEEIPIPTKSPLKRNARLLNRSKSCYMDRLVISETEDPAKKVIK 687
                           ||:.||||     |.....||.. ..|:.|.:.|:..|:        :..
Mosquito   295 KLLAAGVTKTLDMATSPSHQTNE-----TGRGSVRNGS-DERAGSLWADKHGIN--------ITG 345

  Fly   688 DISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGVSAEVKVKDKVLDRQRF------ 746
            |...|..|..|..|..|.::............||.     |..:.:|.:|......|.:
Mosquito   346 DFDVTLKDGQDRELRKVVIKNESRKQHKILKMLPP-----RSEAPQVCLKSPFAHTQSYLFPGES 405

  Fly   747 IDYQAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEKPKENSHRSTTNKRKNPTSVPTVQ--N 809
            ::|:.|:.....     ..:.:|....|...:.:      .....|.|..:..:...:||:.  .
Mosquito   406 VEYEFEITGAGL-----FGRNEESCIWCFGGSFR------IGRIFRITVGQETSNGKLPTINTIG 459

  Fly   810 TNRGGFLTKGVDGPA----PKLAKTDNAKPPPKKPVPKQPPAIETFSQQLQAADKAVLHPQPQCS 870
            :|.||    |.:|.:    .:||..:..:.|  .||...|        ::......:.:|.|..:
Mosquito   460 SNVGG----GYNGKSSYCKKQLALLNMRRAP--GPVLNGP--------RIGMRANFIANPMPSYN 510

  Fly   871 RPVERKEAELARNQR--TCNKVTFAEMELYHQKAEDSKKLQKKLRK--VHFND-----DVKVHCI 926
            .|.|..:..|....|  .||.:   |...|....|.|.|...:::|  :|..:     :.:.|.:
Mosquito   511 VPSELYDLILTSPSRAEVCNAL---ERPPYCLSEELSPKNYARIKKTLIHLEEIRLQIEFRKHDL 572

  Fly   927 ERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWAN-QWLKHGSVDAV 990
            :|     :.....:..:.|.:::..|.|..|.     |.|.   .|:...|.| ..:..|.:..|
Mosquito   573 DR-----AHFTPEESFLALEVANIAEARPSIL-----VGDC---VRATAPWTNDSTIYQGVIHRV 624

  Fly   991 AEQDVLMPIPPEFDSFKN--------------YREIFVPLMKLELLSTIERDYKINNKNTFSVSL 1041
            ....||:.....|.|..|              :|:....:.:::|...:|  |....:......:
Mosquito   625 LHSRVLIKFDQTFHSRYNGESYAIQFTFGRSSFRKQHHAIKRMQLTHGLE--YLFPERINVQEPM 687

  Fly  1042 INVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQDIS 1106
            :||           |:|::  |:.||.                              |.::.|.:
Mosquito   688 LNV-----------RLNAR--GELVLE------------------------------ESMEGDCT 709

  Fly  1107 EEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQTVNEVSLPKQPFTFKGCHK 1171
            :.                              |..|.|..                        .
Mosquito   710 KG------------------------------RVLPWCNA------------------------A 720

  Fly  1172 LNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHS 1236
            ||.:|:..:::..:   .:.:|...:|.|||||||:..|.||..|.:    |.....::::...|
Mosquito   721 LNRYQKQAIVNVLR---GEARPMPHIIFGPPGTGKTVTIVELIHQLI----ANVPSARLIVVTPS 778

  Fly  1237 NTAVDHIV------GLL--GSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQR 1293
            |:|...|.      |:|  |..:|::...|..  |..:.|.::.|.      |..:.|:|:
Mosquito   779 NSAAYLITERLARGGVLEPGDFIRLVAMSQVE--REAVPEHLAQYC------ATVDVAEER---- 831

  Fly  1294 VSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEIS 1358
                                          ||:               .:.|......|.:|:..
Mosquito   832 ------------------------------STF---------------GDVLVTESGLRMKFQAK 851

  Fly  1359 HMCVTRANIICTTLSSCVKLANYV------DFFDICIVDEATQCTEPWTLLPM-RFGLT--HMVL 1414
            |:...|     .|:|:|:.:.:.:      :.|...|||||.|..||..|:|: :...|  .:.|
Mosquito   852 HIGRHR-----VTISTCLGIGSLMMMHFDPNHFTHVIVDEAGQGLEPEVLIPICQVSRTVGSVTL 911

  Fly  1415 VGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDK------PGSYHLMHTKLFKLSTQYRM 1473
            |||.:||..:|...:...:....|:.:|:.......:|:      ...|......|.:::  ||.
Mosquito   912 VGDPKQLGPMVHFNEEQTWTSHLSLLERLLSLRLYSIDRQRFTGDTAGYDPRLVTLLRIN--YRS 974

  Fly  1474 HPEICRWPNQYFYEDQLINAECTARFASPLIPYC----------------VINLKYTCDSNGAQN 1522
            .|.:....|..||:             |.|.||.                ::.|....||:....
Mosquito   975 IPNVLSLYNDMFYD-------------SALEPYVKEVADEDIQLLGAIRDILKLPKPSDSSEDSR 1026

  Fly  1523 K------------------SISNNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALSQVI 1569
            |                  |..|:.||..|.|::..:.:.........|:|:||..|..::.:..
Mosquito  1027 KGFFFCGIDGTNKQSPDSPSWFNSAEACMVHKIVERLYRGERCGPADIGIITPYVMQVRSIRRTF 1091

  Fly  1570 PSHMNITPQ--TVDSYQGLEKDVIIISNARTRGC----------GFLTNYQRLNVALTRPRRCLV 1622
            .:.|...|:  :|:.:||.|:.|||:|..|:...          ||::..:|:||||:|.:..|:
Mosquito  1092 DAAMLEPPKIGSVEEFQGQERKVIIVSTVRSSSAYLAHDSNTKIGFISAPKRINVALSRAKVALI 1156

  Fly  1623 ICGNFEDLKSVEMWRNLLDDARKRKVYF---------------------NLDR--DDVNDLD 1661
            :.||.:.|.:.:.|..:|..|.....|.                     ||.|  ||.:|.|
Mosquito  1157 VIGNPKLLATDKTWMRVLQRALDDGTYCGCTLGSAILRNVSTATRREGNNLQRQYDDDDDED 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	61/273 (22%)
		AAA_19	1194..1251	CDD:289986	20/64 (31%)
		YtxH	<1293..1347	CDD:295162	3/53 (6%)
		AAA_12	1435..1626	CDD:289832	50/242 (21%)
AgaP_AGAP006939	XP_308817.4	AAA_11	721..923	CDD:289831	60/270 (22%)
		AAA_19	743..790	CDD:289986	17/50 (34%)
		AAA_12	962..1162	CDD:289832	48/214 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810