DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Aqr

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_033832.2	Gene:	Aqr / 11834	MGIID:	1276102	Length:	1481	Species:	Mus musculus

Alignment Length:	1527	Identity:	280/1527 - (18%)
Similarity:	525/1527 - (34%)	Gaps:	469/1527 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 DELYDKVADWSKLLSQKVVPDVIEMSQTYPLENEHKDSDSDLDIGAKKPKRTLRISSSSDEDSAD 394
            :|:|:|....|:...:|::  ::|.||.  ||| :...:...::.:|  ...:.|....:|...:
Mouse    47 EEIYEKEIVKSRFAIRKIM--LLEFSQY--LEN-YLWMNYSPEVSSK--AYLMSICCMVNEKFRE 104

  Fly   395 EVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPD-----LPAVRKLSVSSIDSVYE-NKQTKLNSK 453
            .|...:|.:|                    .||     ...:.|.:::..|..:. ::||.|...
Mouse   105 NVPAWETFKK--------------------KPDHFPFFFKCILKAALAETDGEFSLHEQTLLLLF 149

  Fly   454 LKSCLKSPTKTSVDNMENMTETKSCSNRQREQIVA----SRNEPTNICPQKIETNKTSTRKRFVS 514
            |..|..|   ..||.:.:          |.:|:::    ...:|..:   ::|..||...::|.:
Mouse   150 LDHCFNS---LEVDLIRS----------QVQQLISLPMWMGLQPARL---ELELKKTPKLRKFWN 198

  Fly   515 TTSRDELSTTSKEIKDAPKNNVEPPKKMLRSRSKSCYIDRPVELDEHITKNEVPLKKKYESVDNS 579
            ...:::    .|...:|.:...:..:.:.|...|...:.:.:.|.|.:|.::|...:::
Mouse   199 LIKKND----EKMDPEAREQAYQERRFLSRLIQKFISVLKSIPLSEPVTMDKVHYCERF------ 253

  Fly   580 KEELIVTLEAPAMLTTPTKSKTQCVKKKATQTRGRRKTIH-------SRDEIRSLTAEAEENKKI 637
             .||::.|||    ..||:.....:...:      ...:|       .|:|...|.::..:..|.
Mouse   254 -IELMIDLEA----LLPTRRWFNTILDDS------HLLVHCYLSSLVHREEDGHLFSQLLDMLKF 307

  Fly   638 SPAKQTNEEIPIPTKSPLKRNARLLNRSKSCYMDRLV--------------------ISETEDPA 682
            ....:.|::         ..||...|...:.:.||:.                    ::|. |..
Mouse   308 YTGFEINDQ---------TGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEV-DAR 362

  Fly   683 KKVIKDISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGVSAEVKVKDKVLDRQRFI 747
            ..::|...|..|:|...|.:::.:          .|:||||             :|...|::..:
Mouse   363 DSLVKFFGPLSSNTLHQVASYLCL----------LPTLPKN-------------EDTTFDKEFLL 404

  Fly   748 DY----------QAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEKPKENSH----------- 791
            :.          |.:...:....|.:|...||.:......:.:.....||.|..
Mouse   405 ELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRN 469

  Fly   792 ------RSTTNKRKN-PTSVPTVQ--NTNRGGFLTKG---VDGPAPKLAKTDNAKPPPKKPVPKQ 844
                  .||...|:: ..||..::  .:..||.:..|   :..|.......:.|||...:..|.:
Mouse   470 FNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTR 534

  Fly   845 PPAIETFSQQLQAADKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQ 909
            ..|..|.:  |...|..             :.|.|..|....|..:|....:.|..|.:..:...
Mouse   535 VRADVTIN--LNVRDHI-------------KDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFI 584

  Fly   910 KKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRS- 973
            :::..|:            |:|.  ::||..:          ::...|....:|..::|..||:
Mouse   585 EQVGLVY------------VRGC--EIQGMLD----------DKGRVIEDGPEPRPNLRGESRTF 625

  Fly   974 -ILKWANQW-------LKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLEL-----LSTI 1025
             :....||:       :::|:.|.....:|:|...|:.::||...|....||..:.     |..|
Mouse   626 RVFLDPNQYQQDMTNTIQNGAEDVYDTFNVIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDI 690

  Fly  1026 ERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELK--F 1088
            ...|...:...:|.....:.|.|                           ..:||.::..||  |
Mouse   691 ILGYGDPSSAHYSKMPNQIATLD---------------------------FNDTFLSIEHLKASF 728

  Fly  1089 VSGNV-------------FDLTFEILK--------QDISEEKLKNIKQLTARPVVDSLRVELGAL 1132
            ...||             |.:||.:..        .|..|:..:..|.|...|.|
Mouse   729 PGHNVKVTVSDPALQIPPFRITFPVRSGKGKKRKDADGEEDDTEEAKTLIVEPHV---------- 783

  Fly  1133 SAVHQLRSSPLCRRILKPTQTVNEVSLPKQPFTFKGCHKLNEHQENIVLHTY---QRIIDDLQPS 1194
                                      :|.     :|.:..|:.:.|.:..|:   :.|...:||.
Mouse   784 --------------------------IPN-----RGPYPYNQPKRNTIQFTHTQIEAIRAGMQPG 817

  Fly  1195 LTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQF 1259
            ||::.|||||||:.|..:: :..:|.|..   :::.||..|||.|::.    |...:..::.|:.
Mouse   818 LTMVVGPPGTGKTDVAVQI-ISNIYHNFP---EQRTLIVTHSNQALNQ----LFEKIMALDIDER 874

  Fly  1260 HLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNL-- 1322
            ||||.|..|:.....:.||.....|....:::                :|.:|:::|::...:
Mouse   875 HLLRLGHGEEELETEKDFSRYGRVNYVLARRI----------------ELLEEVKRLQKSLGVPG 923

  Fly  1323 -------TSTY--LLQQLQQKEKKLQLISN----------------------------------- 1343
                   |:.|  |.|.:.:.|:.:..:.|
Mouse   924 DASYTCETAGYFFLYQVMSRWEEYMSRVKNSGTACPDAAPDAAQVATFFPFHEYFANAPQPIFKG 988

  Fly  1344 ---------------QLSPPLTQREEFEIS-----------HMCVTRANIICTTLS-SCVKLANY 1381
                           .:....||.|||..|           ::.|..|.||..|.: :.:|..:.
Mouse   989 RSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDL 1053

  Fly  1382 VDF---FDICIVDEATQCTEPWTLLPMRF--------GLTHMVLVGDMQQLPAVVLSKKAIDFGL 1435
            |..   :|..:::||.|..|..|.:|:..        .|...:::||..|||.|:.:       :
Mouse  1054 VKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKN-------M 1111

  Fly  1436 SNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYED-------QLINA 1493
            :...:..:::||.|:..:.|      .....|..|.|....:|...| :.|::       ||:..
Mouse  1112 AFQKYSNMEQSLFTRFVRVG------VPTVDLDAQGRARASLCNLYN-WRYKNLGNLPHVQLLPE 1169

  Fly  1494 ECTARFASPLIPYCVINLKYTCDSNGAQNKS-----ISNNEEARFVAKLLTEMD-KHMPSKRFSY 1552
            ..||. |..|..:.:||::   |..|.....     ..|..||.:|..|...|. ...|:.:.|
Mouse  1170 FSTAN-AGLLYDFQLINVE---DFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKIS- 1229

  Fly  1553 GLISPYQNQCYALSQVIPSHMNITP--------QTVDSYQGLEKDVIIISNARTRGCGFLTNYQR 1609
             :::.|..|.:.:..:|.......|        .|||.:||.:.|.|::|..|||..|.|.:.:|
Mouse  1230 -ILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRR 1293

  Fly  1610 LNVALTRPRRCLVICGNFEDLKSVEMWRNLLD 1641
            |.||::|.|..|.|      ...|.:::|..:
Mouse  1294 LVVAMSRARLGLYI------FARVSLFQNCFE 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	71/343 (21%)
		AAA_19	1194..1251	CDD:289986	19/56 (34%)
		YtxH	<1293..1347	CDD:295162	9/114 (8%)
		AAA_12	1435..1626	CDD:289832	53/211 (25%)
Aqr	NP_033832.2	Helical region with structural similarity to ARM repeat domains. /evidence=ECO:0000250\|UniProtKB:O60306	1..416		76/465 (16%)
		Aquarius_N	18..802	CDD:293008	156/958 (16%)
		Required for assembly of the IB complex. /evidence=ECO:0000250\|UniProtKB:O60306	417..1481		204/1060 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..773		2/18 (11%)
		AAA_11	805..1111	CDD:289831	68/336 (20%)
		AAA_19	808..880	CDD:289986	27/79 (34%)
		UvrD_C_2	1119..1308	CDD:304668	53/207 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1396..1481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910