DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and znfx1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_021333001.1	Gene:	znfx1 / 100536767	ZFINID:	ZDB-GENE-110804-2	Length:	2018	Species:	Danio rerio

Alignment Length:	1358	Identity:	252/1358 - (18%)
Similarity:	450/1358 - (33%)	Gaps:	535/1358 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   598 KSKTQCVKKKATQTRGRRKTIHSRD---EIRSL---TAEAEENKKISPAKQTNEEIPIPTKS--- 653
            :::|:..:.:....|||     .||   |:|:|   |.|....|:.|       |:.|...|
Zfish   212 EARTESQRGRGGHWRGR-----GRDGPPEVRTLGYKTLEGLLEKEAS-------EVAITLSSSTG 264

  Fly   654 -------PLKRN------ARLLNRSKSCYMDRLVISETEDPAKKVIKD----ISPTKSDTTDNVL 701
                   .:.||      .::|.::....:||..:..    ..:|:||    :|......|..:.
Zfish   265 LRNLLEEKVMRNDLVQLVCQVLCKAFQSRIDRNTVMH----LARVVKDSQFFLSILPHHVTGMMS 325

  Fly   702 NFVDVRQTRGP----SVIEAPSLPKN---RGKLRGVSAEVKVKDKVLDRQRFIDYQAEMNAKWKQ 759
            :::..|:.:.|    ::|...|...|   :..:..||..|.:....:::.|........|.
Zfish   326 DYMPARRDQYPQHLSNIISLVSDVLNMFPQSSVHSVSMLVTLLKPTINQLRASGVDVLANT---- 386

  Fly   760 KPKDKKKEDEKLKECRREALKKLSEKPKENSHRSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPA 824
                    |:.|:.. :..:..|.||.:|.:.||                 ::..|||...|.
Zfish   387 --------DQDLERV-QGLVNHLQEKSREGTLRS-----------------DKYSFLTADEDA-- 423

  Fly   825 PKLAKTDNAKPPPKKPVPKQPPAIETFS--------QQLQAADKAVLHPQ------PQCS----- 870
                                ||..|.|.        ::.....|..|.|.      |...
Zfish   424 --------------------PPGEEDFRMMSIYPSFEEFHLDQKPFLRPNIISQSFPNARIYLDT 468

  Fly   871 ----------RPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKVHC 925
                      ||:.....||.|              ::|  .|.:..:..|.|:.   ||::|:.
Zfish   469 HFRLLREDFVRPLREGVKELLR--------------IHH--TEKTNGIPMKNRQF---DDIRVYF 514

  Fly   926 IERV-------KGASSKVQGRKECIKLRLSSYRERR-EWIRRENKPVNDIRQHSRSILKWANQWL 982
            ..||       .|.:.||:            :..|| :::|.||         |:.:|
Zfish   515 DTRVILPLCTSMGIAYKVK------------FDTRRLQFVRWEN---------SKRLL------- 551

  Fly   983 KHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTI-ERDYKINNKNTFSV------- 1039
             :||:..::           .|:|:.:           |.:|: :||.|:..:...::
Zfish   552 -YGSLVCLS-----------MDNFETF-----------LFATVTDRDPKLLRQGEVNLCFSPDSR 593

  Fly  1040 ----------SLINVETQDM--CYRLVTR------VNSKPFGKFVLYTLYCCGMLKETFANLLEL 1086
                      |.:.|||...  .||.|..      .|..||.::::.    |....:..|.||
Zfish   594 AALARVQPSDSFLMVETTAYFEAYRYVLEGLQEQDENDVPFQRYIVE----CKTDVDPPAYLL-- 652

  Fly  1087 KFVSGNVFDLTFEILKQDISEE---KLKNIKQLT--ARPVVDSLRVELGALSAVHQLRSSPLCRR 1146
              |.|..:||:.      |:.|   |:.....||  |.|..:.:.::...|.|:
Zfish   653 --VEGRSYDLSC------IAAEGQGKIPPFNPLTQNAWPDEEKMGLDESQLQAL----------- 698

  Fly  1147 ILKPTQTVNEVSLPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVIS 1211
                     :::|.|:                                |.:|||||||||:.|..
Zfish   699 ---------KLALTKE--------------------------------LAIIQGPPGTGKTHVGL 722

  Fly  1212 ELCLQTLYGNAAKTLDRKILICAHSNTAVDHIV-GLLG----SVLRVMNRDQFHLL-RFGM---- 1266
            ::....|..:.|.:....:|:..::|.|:|..: |:.|    .::||..|.....| |||:
Zfish   723 KIAQALLKNHEAWSNGCPMLVVCYTNHALDQFLEGIHGFLKDGIVRVGGRSNSETLKRFGLRELT 787

  Fly  1267 -----------HEKMSHYS--------------------------------RPFSLEAHFN---- 1284
                       |.:.:|:.                                ..:..|.|::
Zfish   788 RFKDFRKNLPQHLRRAHHEISNNMQEAETLLKAQSAQLECSLRGVLKEDFLEKYISEQHWHSLCL 852

  Fly  1285 -----------------------------------------------KAKEQKLQRVSKE----N 1298
                                                           :.:|::|..:.:|    .
Zfish   853 QPLSDGFETVGKKKPSMMAEWLGIGFSLFFQGPQQTDGEVAEDEDGAQLEEEELIDIDEEADLIQ 917

  Fly  1299 AE--ILKKQHNDLKDEIQQLKEKTNLTSTYLLQ------------------------------QL 1331
            ||  ::..:|.| ||:.:...|:.|:.:...|.                              |:
Zfish   918 AERIVVDAEHGD-KDKYKLKVEEKNIAAMAELMLALNLNDAEAQPGQNQTQTHGHAQADEQEWQM 981

  Fly  1332 Q--QKEKKLQLISNQL--SPPLTQREE--------------FEISHMCVTR-------------- 1364
            |  ||:|..|:...:|  :..::::||              :::..:.|.|
Zfish   982 QGHQKKKLRQMARKELKKTSAMSEKEERRIRDVWSLSLKDRWKLYRLWVLRYRSDLRTKALASEQ 1046

  Fly  1365 -----------------------ANIICTTLSSCVKLANYVDFFD--ICIVDEATQCTEPWTLLP 1404
                                   |.::..|.:...|....:....  :.||:||.:..|..|:..
Zfish  1047 VYQEAAERLNEIRRHEDLSVLRQARVVGMTTTGAAKYRQALQQLQPRLVIVEEAAEVLEAHTITT 1111

  Fly  1405 MRFGLTHMVLVGDMQQL-PAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLS 1468
            :.....|::|:||.||| |:..:.:.|.:|.|..|||:|:.|              ::....:|:
Zfish  1112 LSKACQHLILIGDHQQLRPSATVYELAKNFSLEVSMFERLVR--------------VNFPFVRLN 1162

  Fly  1469 TQYRMHPEICRWPNQYFYEDQLINAECTARFASPLIPYCVINLKYT----CDSNGAQNKSISNNE 1529
            .|:||.|.|.|....:.| ..|.|.....::.:  :...:.||.:.    .:......:|..|..
Zfish  1163 YQHRMRPSIARLLTPHIY-SSLENHPSVLKYDN--VKGVLTNLFFVDHIQPEEEIKDGRSHQNPH 1224

  Fly  1530 EARFVAKLLTEM--DKHMPSKRFSYGLISPYQNQCYALSQVIPS--HMNITPQTVDSYQGLEKDV 1590
            |||||.:|...:  ..:.||:   ..:::.|..|.:.|.:::||  ...:....||.|||.|.|:
Zfish  1225 EARFVVELCQYLLFQDYKPSQ---ITILTTYTGQLHCLRKLMPSPKFSGVKVHVVDKYQGEENDI 1286

  Fly  1591 IIISNART---RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARK 1645
            ||:|..|:   |..|||....|:.|||:|.:..|...||.:.|.||.:|.|::...|:
Zfish  1287 IILSLVRSNPQRRVGFLNIPNRVCVALSRAKMGLYCIGNMDMLSSVTLWSNIIHTLRE 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	70/454 (15%)
		AAA_19	1194..1251	CDD:289986	19/61 (31%)
		YtxH	<1293..1347	CDD:295162	17/93 (18%)
		AAA_12	1435..1626	CDD:289832	54/201 (27%)
znfx1	XP_021333001.1	AAA_11	689..>846	CDD:331082	33/208 (16%)
		AAA_11	<985..1134	CDD:331082	26/148 (18%)
		AAA_12	1143..1327	CDD:315700	56/203 (28%)
		LELP1	1511..1629	CDD:317458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910