DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7504 and znfx1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_012808186.2	Gene:	znfx1 / 100486840	XenbaseID:	XB-GENE-1218977	Length:	1889	Species:	Xenopus tropicalis

Alignment Length:	996	Identity:	191/996 - (19%)
Similarity:	333/996 - (33%)	Gaps:	385/996 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   894 EMELYHQKAEDSKKLQKKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIR 958
            |:.:||   :|:...::|.      ||::::...|:....        |..|.: :|:     :.
Frog   366 ELLMYH---DDNASHKRKF------DDIRIYFDTRIISPL--------CTSLGI-AYK-----VH 407

  Fly   959 RENKPVNDIR-QHSRSILKWANQWLKHGSVDAVAEQDVLMPIPPEFDSF-------KNYREI--- 1012
            .:..|:..:| |:|:.:|        :||:..:::.:        |::|       ::..|:
Frog   408 FDTTPLKMVRWQNSKRLL--------YGSLVCLSKDN--------FETFLFATVSNRDAAELANG 456

  Fly  1013 -----FVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDM--CYRLV----TRVNSK--PFGK 1064
                 |..|.:..|..|...|           |.:.|||...  .||.|    ..::.:  ||.|
Frog   457 EVQLQFSELSRALLAQTQPND-----------SFLMVETTAYFEAYRHVLEGLQEIDDQDVPFQK 510

  Fly  1065 FVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTAR--PVVDSLRV 1127
               |.:.|...::.      .|....|..:||:..|.:........|||..|.:|  |.:|.|..
Frog   511 ---YIVDCQNQVRS------PLYLDMGISYDLSCLIAENSDKARIRKNINILESREWPSMDVLGF 566

  Fly  1128 ELGALSAVHQLRSSPLCRRILKPTQTVNEVSLPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQ 1192
            :...:.||                    :::|.|:
Frog   567 DESQMEAV--------------------QLALTKE------------------------------ 581

  Fly  1193 PSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRK---ILICAHSNTAVD-------HIVGLL 1247
              |.:|||||||||:.|..::....|..:.|...:.:   :|:..::|.|:|       |.:|
Frog   582 --LAIIQGPPGTGKTYVGLKIARTLLSNSDAWQFEGRCYPVLVVCYTNHALDQFLEGIQHFLG-- 642

  Fly  1248 GSVLRVMNRD------QFHL----------------LRFG------------------------- 1265
            ..::||..|.      ||.|                ||.|
Frog   643 KGIVRVGGRSNSEVLKQFTLRQLRASPDFHRNVPPHLRRGYFEIKQSMKESEQKLQEGAQLLQCS 707

  Fly  1266 ----MHE-------KMSHYSRPFSLE--------------------------------------A 1281
                :||       |..|:....|:|                                      |
Frog   708 VSGIIHERFLENYMKAEHWDSLLSIEEDDDFCFQNSRGKPSAIVEWLALGVTPYARTPDLNGAGA 772

  Fly  1282 HFNKAKEQKLQRVSKENAEIL-------------------------------------------- 1302
            .....:|::.:.|..|..|::
Frog   773 QPQDLQEEEEEEVEDEEDELIEIPEEADIIQAERVLDGDEEAARPKRKDTNDVRELADLLLAMSL 837

  Fly  1303 ----------------------KKQHNDLKDEIQQLKEKT-------------NLTSTYLL---- 1328
                                  ||....:|:|:::|...|             |:.|.:.|
Frog   838 ENKEQSENAVETGEWEFTRKQKKKSKKKVKNELRKLDSMTAEEADQVTDIWHLNIRSRWRLYRFW 902

  Fly  1329 ---------QQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDF 1384
                     |::...|:|.|..:::|:....|.:...:.|     |.:|..|.:...|....:..
Frog   903 LHCYQLGIRQKILSHEEKYQEHADRLAELRVQEDLVILKH-----AQVIGMTTTGAAKYRKILQE 962

  Fly  1385 FD--ICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQL-PAVVLSKKAIDFGLSNSMFDRIQRS 1446
            ..  |.||:||.:..|...:..:.....|::|:||.||| |:..:...|.:|.|..|:|:|:.||
Frog   963 VKPRIVIVEEAAEVLEAHIITTLSSACQHLILIGDHQQLRPSANVYDLAKNFNLEVSLFERLIRS 1027

  Fly  1447 LQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTARFASPLIPYCVINL 1511
                          :....:|:.|:||.|||.|....:.|: :|.|......:.|  |.....||
Frog  1028 --------------NLPFVRLNYQHRMRPEIARLLTPHIYK-ELDNHPSVLNYES--IKGVSTNL 1075

  Fly  1512 KYT----CDSNGAQNKSISNNEEARFVAKLLTEM--DKHMPSKRFSYGLISPYQNQCYALSQVIP 1570
            .:.    .:......||..|..||:|:.:|....  .::.||:   ..:::.|..|.:.|.:::|
Frog  1076 FFVEHNFLEQEIKDGKSHQNMHEAKFIVELCKYFLCQEYKPSQ---ITILTTYTGQLFCLRKLMP 1137

  Fly  1571 S--HMNITPQTVDSYQGLEKDVIIISNARTR---GCGFLTNYQRLNVALTRPRRCLVICGNFEDL 1630
            :  ...:....||.|||.|.|:|::|..|:.   ..|||....|:.|||:|.::.|...||...|
Frog  1138 AKKFSGVKVHVVDKYQGEENDIILLSLVRSNKEGRVGFLQISNRICVALSRAKKGLFCIGNMGML 1202

  Fly  1631 KSVEMW---------RNLLDD 1642
            ..|.:|         ||.:.|
Frog  1203 GKVNLWSCINLTLRQRNQIGD 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	73/457 (16%)
		AAA_19	1194..1251	CDD:289986	19/66 (29%)
		YtxH	<1293..1347	CDD:295162	17/145 (12%)
		AAA_12	1435..1626	CDD:289832	53/201 (26%)
znfx1	XP_012808186.2	PRK12678	<5..>121	CDD:237171
		EEXXEc_NFX1	565..>649	CDD:350694	24/137 (18%)
		AAA_11	<869..1003	CDD:404072	30/138 (22%)
		EEXXEc_NFX1	<943..1038	CDD:350694	27/108 (25%)
		SF1_C_Upf1	1040..1209	CDD:350195	48/174 (28%)
		exchanger_TraA	<1281..>1532	CDD:411343
		NF-X1-zinc-finger	1425..1469	CDD:100116
		PRK03918	<1605..>1785	CDD:235175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910