DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and upf1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_002938872.2	Gene:	upf1 / 100135270	XenbaseID:	XB-GENE-6258022	Length:	1100	Species:	Xenopus tropicalis

Alignment Length:	757	Identity:	211/757 - (27%)
Similarity:	326/757 - (43%)	Gaps:	197/757 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   993 QDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQD-MCYRLVTR 1056
            |.||:    .::....|:.||.||:||      |.||....|.:        :||| :..|....
Frog   271 QHVLL----RYEDAYQYQNIFGPLVKL------EADYDKKLKES--------QTQDNITVRWDLG 317

  Fly  1057 VNSKPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARP- 1120
            :|.|....|.         |.:|.:   :::.:.|:...|.:   |.|:: ...|.|..:...|
Frog   318 LNKKRIAYFT---------LPKTDS---DMRLMQGDEICLRY---KGDLA-PLWKGIGHVIKVPD 366

  Fly  1121 -----VVDSLRVELGA-LSAVHQLR--------SSPLCRRILKPTQTVNEVS------------- 1158
                 :...||..:|| :...|..:        |....:..|| |..|:|.|
Frog   367 NYGDEIAIELRSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALK-TFAVDETSVSGYIYHKLLGHE 430

  Fly  1159 ---------LPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELC 1214
                     |||: ||.:|...||..|...|....||       .|:||||||||||:     :.
Frog   431 VEDVIIKCQLPKR-FTAQGLPDLNHSQVYAVKTVLQR-------PLSLIQGPPGTGKT-----VT 482

  Fly  1215 LQTLYGNAAKTLDRKILICAHSNTAVD------HIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHY 1273
            ..|:..:.|:..:..:|:||.||.|||      |..||  .|:|:..:.:            ...
Frog   483 SATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGL--KVVRLCAKSR------------EAI 533

  Fly  1274 SRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKL 1338
            ..|.|..|..|:.:       :.|:...|:|        :||||::|...|:       ..||:.
Frog   534 DSPVSFLALHNQIR-------NMESMPELQK--------LQQLKDETGELSS-------ADEKRY 576

  Fly  1339 QLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCV-----KLANYVDFFDICIVDEATQCTE 1398
            :.:..     ..:||       .:..|::||.|   ||     :||. :.|..| ::||:||.||
Frog   577 RALKR-----TAERE-------LLMNADVICCT---CVGAGDPRLAK-MQFRSI-LIDESTQATE 624

  Fly  1399 PWTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTK 1463
            |..::|:..|...::||||..||..||:.|||...|||.|:|:|:.              ::..:
Frog   625 PECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLV--------------VLGIR 675

  Fly  1464 LFKLSTQYRMHPEICRWPNQYFYEDQLINAECTA---------RFASPLIP--YCVINLKYTCDS 1517
            ..:|..||||||.:..:|:..|||..|.|....|         ::..|..|  :.|...:....|
Frog   676 PIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIAS 740

  Fly  1518 NGAQNKSISNNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALSQVI--------PSHMN 1574
            :|.   |..|..||..|.|:.|::.| ..:|....|:|:||:.|...|.|.:        ..:..
Frog   741 SGT---SYLNRTEAANVEKITTKLLK-AGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQE 801

  Fly  1575 ITPQTVDSYQGLEKDVIIISNART---RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMW 1636
            :...:||::||.|||.||:|..|.   :|.|||.:.:||||||||.|..::|.||.:.|....:|
Frog   802 VEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLW 866

  Fly  1637 RNLLDDARKRKVYFNLDRDDVNDLDRSLIK----KMMVNTIN 1674
            .:||:..:::||   |....:|:|..||::    :.:|||||
Frog   867 NHLLNYYKEQKV---LVEGPLNNLRESLMQFSKPRKLVNTIN 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	76/267 (28%)
		AAA_19	1194..1251	CDD:289986	24/62 (39%)
		YtxH	<1293..1347	CDD:295162	11/53 (21%)
		AAA_12	1435..1626	CDD:289832	65/212 (31%)
upf1	XP_002938872.2	DNA2	126..890	CDD:224037	204/740 (28%)
upf1	XP_002938872.2	DEXXQc_UPF1	451..684	CDD:350797	87/311 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010