DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ldbr and DBR1

DIOPT Version :9

Sequence 1:	NP_996022.1	Gene:	ldbr / 38900	FlyBaseID:	FBgn0035838	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_012773.1	Gene:	DBR1 / 853708	SGDID:	S000001632	Length:	405	Species:	Saccharomyces cerevisiae

Alignment Length:	421	Identity:	155/421 - (36%)
Similarity:	227/421 - (53%)	Gaps:	64/421 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIAVEGCAHGELERIYDTIEGIEKVGGTKIDLLLCCGDFQSTRNLEDLQTMAVPKKYLDMCSFY 65
            ::|||:||.||:|.:||..:..|.  ..|.||||:..|||||.|:.:|.:::|:|.||..:..|.
Yeast     4 LRIAVQGCCHGQLNQIYKEVSRIH--AKTPIDLLIILGDFQSIRDGQDFKSIAIPPKYQRLGDFI 66

  Fly    66 KYYSGELVAPVLTIFIGGNHEASNYLQELPYGGWVAPNIYYLGYAGVVNVNGVRIAGISGIFKGH 130
            .||:.|:.|||.|||||||||:..:|..||:||:||.||:|:||:.|:...|:||..:|||:|..
Yeast    67 SYYNNEIEAPVPTIFIGGNHESMRHLMLLPHGGYVAKNIFYMGYSNVIWFKGIRIGSLSGIWKEW 131

  Fly   131 DFLRGHHEFPPYTD-------STCRSVYHVRQLEVFRLKQISGRVDIFLSHDWPTGIYEYGNKAQ 188
            ||   :.:.|.:.|       :..|::||||..::..|..|..|:||.||||||.|:..:|:...
Yeast   132 DF---NKQRPDWNDLENNNWKANIRNLYHVRISDIAPLFMIKHRIDIMLSHDWPNGVVYHGDTKH 193

  Fly   189 LLRKKPFFAADMESGKLGSQPLEELLKAVQPAYWFAAHLHCKFAALVPHNHSQKLGDAESSSSS- 252
            ||:.||||..|::.|||||....:||:.::|.:|.:||||.:|.|.:.||........:|:|.:
Yeast   194 LLKLKPFFEQDIKEGKLGSPVTWQLLRDLRPQWWLSAHLHVRFMASIKHNKRSHEPPNKSTSKTK 258

  Fly   253 ----------SSSEDE-------DEEREKVKKAAPVPPPSKSVPVTKFLALDKCLPRRAFLQVVE 300
                      ||.|||       .||.|...|...          |:|||||||||||.:|:::|
Yeast   259 KNNNEIDLDLSSDEDERSGIMNCQEENEYDSKYGE----------TRFLALDKCLPRRRWLEILE 313

  Fly   301 VPSDPIEGT-----PRLEYDAEW---LAILHSTNHLISVKE----NYYYL--PGKKAGEFTERSN 351
            :..|....:     .|:.:|.|:   |.|.....:|:|.|.    |:..|  ..::.|...:..|
Yeast   314 IEPDTSHASWKDENHRMFWDPEFINNLVICQKNKNLLSNKPFNSVNWIELSQSNREEGRDIDWEN 378

  Fly   352 FTPTEEELEAVTAKFQKLQVPENFERTVPAF 382
            :.     :.|.|...||.:|     |...||
Yeast   379 YA-----IPAYTLDIQKDEV-----RQTKAF 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ldbr	NP_996022.1	Metallophos	1..229	CDD:278574	104/234 (44%)
		MPP_Dbr1_N	3..296	CDD:277322	132/317 (42%)
		DBR1	281..416	CDD:282819	35/116 (30%)
DBR1	NP_012773.1	MPP_Dbr1_N	6..309	CDD:277322	132/317 (42%)
DBR1	NP_012773.1	DBR1	293..>354	CDD:398606	22/70 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346259
Domainoid	1	1.000	212	1.000	Domainoid score	I493
eggNOG	1	0.900	-	-		E1_KOG2863
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I656
Isobase	1	0.950	-	0	Normalized mean entropy	S1349
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004461
OrthoInspector	1	1.000	-	-		oto99889
orthoMCL	1	0.900	-	-		OOG6_102255
Panther	1	1.100	-	-	LDO	PTHR12849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R294
SonicParanoid	1	1.000	-	-		X3163
TreeFam	1	0.960	-	-
	14	13.730