DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ldbr and Dbr1

DIOPT Version :9

Sequence 1:	NP_996022.1	Gene:	ldbr / 38900	FlyBaseID:	FBgn0035838	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_113580.2	Gene:	Dbr1 / 83703	MGIID:	1931520	Length:	550	Species:	Mus musculus

Alignment Length:	601	Identity:	263/601 - (43%)
Similarity:	331/601 - (55%)	Gaps:	124/601 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIAVEGCAHGELERIYDTIEGIEKVGGTKIDLLLCCGDFQSTRNLEDLQTMAVPKKYLDMCSFY 65
            |::||.||.||||::||:|:...|:.|...:||||||||||:.||..||:.||||.||..|.:||
Mouse     1 MRVAVAGCCHGELDKIYETLALAERRGSGPVDLLLCCGDFQAVRNEADLRCMAVPPKYRHMQTFY 65

  Fly    66 KYYSGELVAPVLTIFIGGNHEASNYLQELPYGGWVAPNIYYLGYAGVVNVNGVRIAGISGIFKGH 130
            :|||||..||||||||||||||||:||||||||||||||||||.||||...||||.|||||||.|
Mouse    66 RYYSGEKKAPVLTIFIGGNHEASNHLQELPYGGWVAPNIYYLGLAGVVKYRGVRIGGISGIFKSH 130

  Fly   131 DFLRGHHEFPPYTDSTCRSVYHVRQLEVFRLKQISGRVDIFLSHDWPTGIYEYGNKAQLLRKKPF 195
            |:.:||.|.|||..||.||:||||.:||::|||:...|.||||||||..||.||||.|||:.|.|
Mouse   131 DYRKGHFECPPYNSSTIRSIYHVRNIEVYKLKQLKQPVHIFLSHDWPRNIYHYGNKKQLLKTKSF 195

  Fly   196 FAADMESGKLGSQPLEELLKAVQPAYWFAAHLHCKFAALVPHNHSQKLGDAESSSSSSSSEDEDE 260
            |..::|:..|||....|||:.:||||||:||||.|||||:.|                .:.|:|:
Mouse   196 FRQEVENSTLGSPAASELLEHLQPAYWFSAHLHVKFAALMQH----------------QATDKDQ 244

  Fly   261 EREKVKKAAPVPPPSKSVPVTKFLALDKCLPRRAFLQVVEVPSDPIEGTPR-LEYDAEWLAILHS 324
            ..::                |||||||||||.|.||||:|:..||  ..|. ||||.|||.:|.:
Mouse   245 AGKE----------------TKFLALDKCLPHRDFLQVLEIEHDP--SAPEYLEYDVEWLTVLRA 291

  Fly   325 TNHLISVKENYYYLPGKKAGEFTERSNFTPTEEELEAVTAKF-QKLQVPENFERTVPAFDPAE-Q 387
            |:.||:|....:.:| :..|..| |.:::.|||.::.|..|. ...:||.||..|...:||:: |
Mouse   292 TDDLINVTGGLWNMP-EDNGLHT-RWDYSATEETMKEVMEKLNHDPKVPCNFTMTAACYDPSKPQ 354

  Fly   388 SDYKHMFVDQPKVQLNPQSNTFCATLGIDDPLCLVLLANGLDLPAVGATECK-DRETKSSKLQAV 451
            :..|.:.      ::|||:..|||.|||.|...::..|...:....|..|.: |..|:.|
Mouse   355 TQVKLVH------RINPQTTEFCAQLGITDINVMIQKAREEEHHQCGEYEQQGDPGTEES----- 408

  Fly   452 EEDVAEPLVTPTKRKLNLSLPAPTTAAADTTDENVIDLPEEEAEEAIIA---TETPHVEEPAS-- 511
            |||.:| ..|.|..   ||...|.....|..:|.     |||.|||:.|   ..||.| ||||
Mouse   409 EEDRSE-YNTDTSA---LSSINPDEIMLDEEEEE-----EEEEEEAVSAHSDMNTPSV-EPASDQ 463

  Fly   512 -------------VPASPNV--------------------------------------------- 518
                         :|:|..|
Mouse   464 ASDLSTSFSDIRNLPSSMFVSSDDASRSPASGEGKCGETVESGDEKDLAKFPLKRLSDEHEPEQR 528

  Fly   519 KKLKRRNQNIYQAQED 534
            ||:|||||.||.|.:|
Mouse   529 KKIKRRNQAIYAAVDD 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ldbr	NP_996022.1	Metallophos	1..229	CDD:278574	149/227 (66%)
		MPP_Dbr1_N	3..296	CDD:277322	169/292 (58%)
		DBR1	281..416	CDD:282819	58/137 (42%)
Dbr1	NP_113580.2	Metallophos	1..229	CDD:278574	149/227 (66%)
		MPP_Dbr1_N	3..264	CDD:277322	169/292 (58%)
		DBR1	246..377	CDD:282819	58/156 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..550		44/170 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849551
Domainoid	1	1.000	322	1.000	Domainoid score	I1211
eggNOG	1	0.900	-	-		E1_KOG2863
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9428
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1824
Isobase	1	0.950	-	0	Normalized mean entropy	S1349
OMA	1	1.010	-	-		QHG48623
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004461
OrthoInspector	1	1.000	-	-		oto94191
orthoMCL	1	0.900	-	-		OOG6_102255
Panther	1	1.100	-	-	LDO	PTHR12849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R294
SonicParanoid	1	1.000	-	-		X3163
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740