DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ldbr and Dbr1

DIOPT Version :9

Sequence 1:	NP_996022.1	Gene:	ldbr / 38900	FlyBaseID:	FBgn0035838	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001102907.1	Gene:	Dbr1 / 681234	RGDID:	1598038	Length:	545	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	257/588 - (43%)
Similarity:	331/588 - (56%)	Gaps:	103/588 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIAVEGCAHGELERIYDTIEGIEKVGGTKIDLLLCCGDFQSTRNLEDLQTMAVPKKYLDMCSFY 65
            |::||.||.||||::||:|:...|:.|...:||||||||||:.||..||:.||||.||..|.:||
  Rat     1 MRVAVAGCCHGELDKIYETLALAERRGPGPVDLLLCCGDFQAVRNEADLRCMAVPPKYRHMQTFY 65

  Fly    66 KYYSGELVAPVLTIFIGGNHEASNYLQELPYGGWVAPNIYYLGYAGVVNVNGVRIAGISGIFKGH 130
            :|||||..||||||||||||||||:||||||||||||||||||.||||...||||.|||||||.|
  Rat    66 RYYSGEKKAPVLTIFIGGNHEASNHLQELPYGGWVAPNIYYLGLAGVVKYRGVRIGGISGIFKSH 130

  Fly   131 DFLRGHHEFPPYTDSTCRSVYHVRQLEVFRLKQISGRVDIFLSHDWPTGIYEYGNKAQLLRKKPF 195
            |:.:||.|.|||..||.||:||||.:||::|||:...|.||||||||..||.||||.|||:.|.|
  Rat   131 DYRKGHFECPPYNSSTIRSIYHVRNIEVYKLKQLKQPVHIFLSHDWPRNIYHYGNKKQLLKTKSF 195

  Fly   196 FAADMESGKLGSQPLEELLKAVQPAYWFAAHLHCKFAALVPHNHSQKLGDAESSSSSSSSEDEDE 260
            |..::|:..|||....|||:.::|||||:||||.|||||:.|..:.|               |..
  Rat   196 FRQEVENSTLGSPAASELLEHLKPAYWFSAHLHVKFAALMQHQATDK---------------EQA 245

  Fly   261 EREKVKKAAPVPPPSKSVPVTKFLALDKCLPRRAFLQVVEVPSDPIEGTPR-LEYDAEWLAILHS 324
            .:|                 |||||||||||.|.||||:|:..||  ..|. ||||.||||:|.:
  Rat   246 GKE-----------------TKFLALDKCLPHRDFLQVLEIEHDP--SAPEYLEYDVEWLAVLRA 291

  Fly   325 TNHLISVKENYYYLPGKKAGEFTERSNFTPTEEELEAVTAKF-QKLQVPENFERTVPAFDPAEQS 388
            |:.|::|....:.:| :..|..| |.:::.|||.::.|..|. ...::|.||..|...:||::
  Rat   292 TDDLMNVTGGLWNMP-ENNGLHT-RWDYSATEEAMKDVMEKLNHDPRIPCNFSMTAACYDPSK-- 352

  Fly   389 DYKHMFVDQPKVQL----NPQSNTFCATLGIDD------------PLCLVLLANGLDLPAVGATE 437
                   .|.:|||    :||:..|||.|||.|            .||...:..| ||....:.|
  Rat   353 -------PQTQVQLVHRISPQTTKFCAQLGITDINVMIQKAKEEHHLCGEYVQQG-DLGTDDSEE 409

  Fly   438 CKDR---ETKSSKLQAV--------EEDVAEPLVTPTKRKLNLSLPAPTTAAA---DTTDENVID 488
              ||   .|.:|.|.::        ||:..|..|: |...:|.....|::..|   .|:..::.:
  Rat   410 --DRSEYNTDTSALSSINPDEIMLDEEEEEEEAVS-THSDMNTPSVEPSSDQASDLSTSFSDIRN 471

  Fly   489 LPEEEAEEAIIATETPHVEE----------------PASVPASPNV------KKLKRRNQNIYQA 531
            ||......:..|:.:|..||                ..||....|.      |::|||||.||.|
  Rat   472 LPSSMFVSSDDASRSPASEEGKSGETVECGDEKDLVEFSVKRLSNEHEPEQRKRIKRRNQAIYAA 536

  Fly   532 QED 534
            .:|
  Rat   537 VDD 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ldbr	NP_996022.1	Metallophos	1..229	CDD:278574	148/227 (65%)
		MPP_Dbr1_N	3..296	CDD:277322	169/292 (58%)
		DBR1	281..416	CDD:282819	58/140 (41%)
Dbr1	NP_001102907.1	Metallophos	1..229	CDD:278574	148/227 (65%)
		MPP_Dbr1_N	3..264	CDD:277322	169/292 (58%)
		DBR1	246..377	CDD:282819	59/160 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353194
Domainoid	1	1.000	321	1.000	Domainoid score	I1195
eggNOG	1	0.900	-	-		E1_KOG2863
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9428
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1823
OMA	1	1.010	-	-		QHG48623
OrthoDB	1	1.010	-	-		D1047278at2759
OrthoFinder	1	1.000	-	-		FOG0004461
OrthoInspector	1	1.000	-	-		oto97714
orthoMCL	1	0.900	-	-		OOG6_102255
Panther	1	1.100	-	-	LDO	PTHR12849
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3163
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770