DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ldbr and dbr-1

DIOPT Version :9

Sequence 1:	NP_996022.1	Gene:	ldbr / 38900	FlyBaseID:	FBgn0035838	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_491868.2	Gene:	dbr-1 / 172357	WormBaseID:	WBGene00000937	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	201/524 - (38%)
Similarity:	272/524 - (51%)	Gaps:	93/524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIAVEGCAHGELERIYDTIEGIEKVGGTKIDLLLCCGDFQSTRNLEDLQTMAVPKKYLDMCSFY 65
            ::|||.||:|||::.||:|:..||:..|.|.|||:||||:|:.||..||..|::|.||..:.:||
Worm    41 IRIAVVGCSHGEMDAIYETMTLIEQKNGYKFDLLICCGDYQAVRNYGDLPHMSIPPKYRSLQTFY 105

  Fly    66 KYYSGELVAPVLTIFIGGNHEASNYLQELPYGGWVAPNIYYLGYAGVVNVNGVRIAGISGIFKGH 130
            ||||||..|||||:|||||||||.||.|||.||||||||||:|:|..:....:||||:||||...
Worm   106 KYYSGEQKAPVLTLFIGGNHEASGYLCELPNGGWVAPNIYYMGFANCIRFANLRIAGLSGIFSQG 170

  Fly   131 DFLRGHHEFPPYTDSTCRSVYHVRQLEVFRLKQ--------ISGRVDIFLSHDWPTGIYEYGNKA 187
            ||...|:|.|.:::...:|.||||.:::|||:|        ||..:||.||||||.||.::|:|.
Worm   171 DFQFSHYERPSFSERDVKSAYHVRNVDMFRLRQLKSDNENKISNPIDIMLSHDWPGGIPDFGDKE 235

  Fly   188 QLLRKKPFFAADMESGKLGSQPLEELLKAVQPAYWFAAHLHCKFAALVPHNHSQKLGDAESSSSS 252
            .|.|||..|.||..|||||:....:|:...:|.|:.|||||..|||||||            ..|
Worm   236 WLFRKKDLFEADHNSGKLGNPSGMKLIYDCRPRYYLAAHLHIAFAALVPH------------KGS 288

  Fly   253 SSSEDEDEEREKVKKAAPVPPPSKSVPVTKFLALDKCLPRRAFLQVVEV-PSDPIEGTPRLEYDA 316
            .|..               |.|      |:||:|||.:|.|.|:|.:|: .:|  :....|.||.
Worm   289 GSGR---------------PQP------TRFLSLDKPIPGRKFMQALELNVAD--DAKLELSYDP 330

  Fly   317 EWLAILHSTNHLISVKENYYYLPGKKAGE--FTERSNFTPTEEELEAVTAKFQKLQV-PENFERT 378
            :|||||.:|:.|.:..:....||...:..  ..||.:|.||.|||:.: .|...|.: .::|::|
Worm   331 QWLAILRNTDLLTTGTKEQLILPDMASNRPCVYERKDFRPTAEELKEI-EKLGDLTIRTDSFQQT 394

  Fly   379 VPAFDPAEQSDYKHMFVDQPKVQLNPQSNTFCATLGIDDPLCLVLLANGLDLPAVGATECKDRET 443
            .|   |.::.......|.......||||..||..|||                         |:.
Worm   395 AP---PLKEITESSKNVPPSAYYRNPQSAEFCQWLGI-------------------------RDL 431

  Fly   444 KSSKLQAVEEDVAEPLVTPTKRKLNLSLPAPTTAAADTTDENVI-------DLPE-------EEA 494
            ....::...|.|..|....|:...|..   |.....|..||:.:       |.||       |:.
Worm   432 NQMLVEKTSEHVGTPYYMMTQDDANAK---PNQDDVDFGDEDFVIDRGHTSDEPEAKKSRLDEDK 493

  Fly   495 EEAI 498
            .||:
Worm   494 FEAV 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ldbr	NP_996022.1	Metallophos	1..229	CDD:278574	125/235 (53%)
		MPP_Dbr1_N	3..296	CDD:277322	145/300 (48%)
		DBR1	281..416	CDD:282819	47/138 (34%)
dbr-1	NP_491868.2	Metallophos	41..277	CDD:278574	125/235 (53%)
		MPP_Dbr1_N	43..311	CDD:277322	145/300 (48%)
		DBR1	293..428	CDD:282819	48/146 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166749
Domainoid	1	1.000	262	1.000	Domainoid score	I1047
eggNOG	1	0.900	-	-		E1_KOG2863
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9428
Inparanoid	1	1.050	320	1.000	Inparanoid score	I1496
Isobase	1	0.950	-	0	Normalized mean entropy	S1349
OMA	1	1.010	-	-		QHG48623
OrthoDB	1	1.010	-	-		D1047278at2759
OrthoFinder	1	1.000	-	-		FOG0004461
OrthoInspector	1	1.000	-	-		oto18118
orthoMCL	1	0.900	-	-		OOG6_102255
Panther	1	1.100	-	-	LDO	PTHR12849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R294
SonicParanoid	1	1.000	-	-		X3163
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790