DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KRT84 and LamC

DIOPT Version :9

Sequence 1:NP_149034.2 Gene:KRT84 / 3890 HGNCID:6461 Length:600 Species:Homo sapiens
Sequence 2:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster


Alignment Length:459 Identity:119/459 - (25%)
Similarity:198/459 - (43%) Gaps:78/459 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   118 GGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEIDPNAQRVKKDEKEQIKTLNNKFASFIDK 182
            ||.....|||... |.:|:.|:                      ::.|||:::.||::.|.:||:
  Fly    22 GGASTSSRVGATS-PTSPTRTS----------------------RQQEKEELQHLNDRLACYIDR 63

Human   183 VRFLEQQNKLLETKWSFLQEQ-KCIRSNLEPLFESYITNLRRQLEVLVSDQARLQAERNHL---- 242
            :|.||.:|..|..:.:..|:. ....|||:.::|..:...|:.|:....::|:|:.:...|    
  Fly    64 MRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEEN 128

Human   243 QDVLEGFKKKYEEEVVCRANA---------------------------------ENEFVA----- 269
            .|:.....||.:|..|...||                                 |||.:.     
  Fly   129 DDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDD 193

Human   270 LKKDVDAAFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQS--HISETSVIVKMDNSRDLNLDG 332
            |:|.::|..:.:.|||....:|.:|:.|...::.:|:...:|  .|..:.:..::....:..|..
  Fly   194 LRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQ 258

Human   333 IIAEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEH 397
            .:.|::.|||...|.:|.:.|..|..:.:.::..|.:..........|:..:...|..|.|::::
  Fly   259 SLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQN 323

Human   398 AKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIEI 462
            .:...|.|.|.:.|.|...:.........:|.||..||:.:.:||.||.|||.||:.|:.||:||
  Fly   324 LEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEI 388

Human   463 ATYRRLLEGEESRL-CEGVG-PVNISVSSSRGGLVCGPEPLVAGSTLSRGGVTFSGSSSVCATSG 525
            |.|.:||.|||.|| .|..| |...|..||.|      ..|.|.::...|.||.||..|  ||.|
  Fly   389 AAYDKLLCGEERRLNIESPGRPTTDSGISSNG------SHLTASASSRSGRVTPSGRRS--ATPG 445

Human   526 VLAS 529
            :..|
  Fly   446 ISGS 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT84NP_149034.2 Head 1..165 8/46 (17%)
Keratin_2_head 16..161 CDD:292825 8/42 (19%)
Filament 165..475 CDD:278467 90/354 (25%)
Coil 1A 166..200 12/33 (36%)
Linker 1 201..210 2/9 (22%)
Coil 1B 211..311 26/141 (18%)
DUF5082 215..315 CDD:293493 28/143 (20%)
Nnf1 293..411 CDD:281911 22/119 (18%)
Linker 12 312..328 1/15 (7%)
Coil 2 329..472 42/142 (30%)
RILP-like <375..>444 CDD:304877 16/68 (24%)
Tail 473..600 22/59 (37%)
LamCNP_001260974.1 Filament 45..401 CDD:278467 90/355 (25%)
ATP-synt_B <67..>142 CDD:304375 17/74 (23%)
MreC <178..>224 CDD:302802 12/45 (27%)
LTD 473..574 CDD:279300
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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