DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp3 and ARP3

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_012599.3	Gene:	ARP3 / 853528	SGDID:	S000003826	Length:	449	Species:	Saccharomyces cerevisiae

Alignment Length:	446	Identity:	259/446 - (58%)
Similarity:	305/446 - (68%)	Gaps:	43/446 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PACVIDVGTGYSKLGFAGNKEPQFIIPSAIA------IKESARVG-----------------DTN 47
            ||.|:|.|||.:|||||||..|.::.|:|||      .|:|:.||                 .||
Yeast     7 PAVVMDNGTGLTKLGFAGNDSPSWVFPTAIATAAPSNTKKSSGVGAPSAVSNEASYFGNSTSATN 71

  Fly    48 TRRIT-----------KGIEDLDFFIGDEAFDAT---GYSIKYPVRHGLVEDWDLMERFLEQCVF 98
            ....|           :|.|||||:||:||..|:   .||:.||:|||.||:||.||||.|..:|
Yeast    72 FNGATGGLLSNNLSGKRGTEDLDFYIGNEALVASQGPSYSLSYPIRHGQVENWDHMERFWENSIF 136

  Fly    99 KYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTL 163
            ||||.|||||:|||||||||.|||||..|||.||:||..||||||||||||||||.|....:|:|
Yeast   137 KYLRTEPEDHFFLLTEPPLNPPENREQVAEIFFESFNCAGLYIAVQAVLALAASWTSSKVTDRSL 201

  Fly   164 TGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNITSFIQSLLREREVGIPPEQSLETAKAIK 228
            ||.|:||||||||||||||||||||.||:||||||:||.|||||||||.   ..:.||.||:.||
Yeast   202 TGTVIDSGDGVTHVIPVAEGYVIGSAIKNIPIAGRDITLFIQSLLRERG---EADTSLRTAEKIK 263

  Fly   229 EKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFT 293
            :::||:||||.|||.|:|.:|.|:.: |...|........||:||||||.|||||:||.::.||.
Yeast   264 QEYCYVCPDIVKEFNKFDKDPSKFAQ-FVVENQEKTRRKVVDIGYERFLAPEIFFNPEIASSDFL 327

  Fly   294 IPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRI 358
            .||..:||..||.||||||:.||||||||||||||||||||||||:|..|:.|:..||.||  ..
Yeast   328 TPLPTVVDQTIQACPIDVRKGLYNNIVLSGGSTMFKDFGRRLQRDLKSIVNNRIAQSELLS--GT 390

  Fly   359 KPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKAAYEEYGPSICRHNPVF 414
            |...:||.||:|..||.|||||||:||.|.||...||||..||||||.|.|:..:|
Yeast   391 KSTGVDVSVISHRKQRNAVWFGGSLLAQTAEFKGYCHTKKDYEEYGPEIVRNFSLF 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	259/446 (58%)
ARP3	NP_012599.3	COG5277	1..445	CDD:227602	258/443 (58%)
ARP3	NP_012599.3	PTZ00280	5..446	CDD:240343	258/444 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	274	1.000	Domainoid score	I271
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68483
Inparanoid	1	1.050	472	1.000	Inparanoid score	I228
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54102
OrthoFinder	1	1.000	-	-		FOG0002894
OrthoInspector	1	1.000	-	-		oto99893
orthoMCL	1	0.900	-	-		OOG6_102024
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R83
SonicParanoid	1	1.000	-	-		X1671
TreeFam	1	0.960	-	-
	14	13.860