DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp3 and POTEJ

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_011509985.1	Gene:	POTEJ / 653781	HGNCID:	37094	Length:	1048	Species:	Homo sapiens

Alignment Length:	409	Identity:	141/409 - (34%)
Similarity:	209/409 - (51%)	Gaps:	45/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VIDVGTGYSKLGFAGNKEPQFIIPSAIAIKESARVGDTNTRRITKGIEDLDFFIGDEAFDATG-Y 72
            |||.|:|..|.||||:..|:.:.||.        ||....:.:..|:...:.::|.||....| .
Human   682 VIDNGSGMCKAGFAGDDAPRAVFPSI--------VGCPRQQGMMGGMHQKESYVGKEAQSKRGIL 738

  Fly    73 SIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVP 137
            ::|||:.||::.:||.||:......:..||..||:|..||||.|||...|||...:|||||||.|
Human   739 TLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTP 803

  Fly   138 GLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNITS 202
            .:|:|:||:|:|..|       .|| ||||:||||||||.:|:.:|..:......:.:|||.:|.
Human   804 AMYVAIQAMLSLYTS-------GRT-TGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTD 860

  Fly   203 FIQSLLREREVGIPPEQSLETAKAIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKAPF 267
            ::..:|.||..........|..:.||||.||:..|..:|.|        .:.:.|.:....:.|.
Human   861 YLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMA--------MVASSSSLEKSYELPD 917

  Fly   268 N--VDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKD 330
            .  :.:..|.|..||..|.|.|...: :..:.|...|.|....:|:|:.||.|.|||||:||:..
Human   918 GQVITISNEWFRCPEALFQPCFLGME-SCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPG 981

  Fly   331 FGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCH 395
            ...|:|::|                ..:.|..:.:::|....::|:||.|||:|||...|.|:..
Human   982 MAHRMQKEI----------------AALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWI 1030

  Fly   396 TKAAYEEYGPSICRHNPVF 414
            :|..|:|.||||. |...|
Human  1031 SKQEYDESGPSIV-HRKCF 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	141/409 (34%)
POTEJ	XP_011509985.1	Ank_2	106..209	CDD:289560
		ANK	130..265	CDD:238125
		ANK repeat	137..166	CDD:293786
		ANK repeat	168..209	CDD:293786
		ANK	206..330	CDD:238125
		ANK repeat	211..242	CDD:293786
		Ank_2	216..308	CDD:289560
		ANK repeat	244..275	CDD:293786
		ANK repeat	277..308	CDD:293786
		NBD_sugar-kinase_HSP70_actin	674..1048	CDD:302596	140/407 (34%)
		ACTIN	678..1048	CDD:214592	140/407 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820