DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp3 and POTEI

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001358855.1	Gene:	POTEI / 653269	HGNCID:	37093	Length:	1097	Species:	Homo sapiens

Alignment Length:	417	Identity:	143/417 - (34%)
Similarity:	208/417 - (49%)	Gaps:	61/417 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VIDVGTGYSKLGFAGNKEPQFIIPSAIAIKESARVGDTNTRRITKGIEDLDFFIGDEAFDATG-Y 72
            |||.|:|..|.||||:..|:.:.||.        ||....:.:..|:...:.::|.||....| .
Human   731 VIDNGSGMCKAGFAGDDAPRAVFPSI--------VGRPRQQGMMGGMHQKESYVGKEAQSKRGIL 787

  Fly    73 SIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVP 137
            ::|||:.||::.:||.||:......:..||..||:|..||||.|||...|||...:|||||||.|
Human   788 TLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTP 852

  Fly   138 GLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNITS 202
            .:|:|:||:|:|..|       .|| ||||:||||||||.:|:.:|..:......:.:|||.:|.
Human   853 AMYVAIQAMLSLYTS-------GRT-TGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTD 909

  Fly   203 FIQSLLREREVGIPPEQSLETAKAIKEKHCYICPDIAKEFA----------KYDTEPGKWIRNFS 257
            ::..:|.||..........|..:.||||.||:..|..:|.|          .|:...|:.|
Human   910 YLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMAASSSSLEKSYELPDGQVI---- 970

  Fly   258 GVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLS 322
                        .:|.|.|..||..|.|.|...: :..:.|...|.|....:|:|:.||.|.|||
Human   971 ------------TIGNEWFRCPEALFQPCFLGME-SCGIHETTFNSIMKSDVDIRKDLYTNTVLS 1022

  Fly   323 GGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLAST 387
            ||:||:.....|:|::|                ..:.|..:.:::|....::|:||.|||:|||.
Human  1023 GGTTMYPGMAHRMQKEI----------------AALAPSMLKIRIIAPPKRKYSVWVGGSILASL 1071

  Fly   388 PEFYQVCHTKAAYEEYGPSICRHNPVF 414
            ..|.|:..:|..|:|.||||. |...|
Human  1072 STFQQMWISKQEYDESGPSIV-HRKCF 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	143/417 (34%)
POTEI	NP_001358855.1	Ank_2	158..>361	CDD:393464
		ANK repeat	174..203	CDD:293786
		ANK repeat	205..236	CDD:293786
		ANK repeat	238..269	CDD:293786
		ANK repeat	271..302	CDD:293786
		ANK repeat	304..335	CDD:293786
		CCDC144C	670..>723	CDD:373382
		NBD_sugar-kinase_HSP70_actin	723..1097	CDD:388382	142/415 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820