Protein Alignment Arp3 and ACTA1

DIOPT Version :10

• Sequence 1: NP_523968.1
• Gene: Arp3 / 38898
• FlyBaseID: FBgn0262716
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_001091.1
• Gene: ACTA1 / 58
• HGNCID: 129
• Length: 377
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 154/419 - (36%)
• Similarity: 215/419 - (51%)
• Gaps: 61/419 - (14%)

  Fly     7 ACVIDVGTGYSKLGFAGNKEPQFIIPSAIAIKESARVGDTNTRRITKGIEDLDFFIGDEAFDATG 71
            |.|.|.|:|..|.||||:..|:.:.||.        ||....:.:..|:...|.::||||....|
Human     9 ALVCDNGSGLVKAGFAGDDAPRAVFPSI--------VGRPRHQGVMVGMGQKDSYVGDEAQSKRG 65

  Fly    72 -YSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFN 135
             .::|||:.||::.:||.||:......:..||..||:|..||||.|||...|||...:|||||||
Human    66 ILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFN 130

  Fly   136 VPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNI 200
            ||.:|:|:||||:|.||       .|| ||||:||||||||.:|:.|||.:...|..:.:|||::
Human   131 VPAMYVAIQAVLSLYAS-------GRT-TGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDL 187

  Fly   201 TSFIQSLLREREVGIPPEQSLETAKAIKEKHCYICPDIAKEFA----------KYDTEPGKWIRN 255
            |.::..:|.||..........|..:.||||.||:..|...|.|          .|:...|:.|
Human   188 TDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVI-- 250

  Fly   256 FSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVRRPLYNNIV 320
                          .:|.|||..||..|.|.|...: :..:.|...|.|..|.||:|:.||.|.|
Human   251 --------------TIGNERFRCPETLFQPSFIGME-SAGIHETTYNSIMKCDIDIRKDLYANNV 300

  Fly   321 LSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLA 385
            :|||:||:.....|:|::|.                .:.|..:.:::|....::|:||.|||:||
Human   301 MSGGTTMYPGIADRMQKEIT----------------ALAPSTMKIKIIAPPERKYSVWIGGSILA 349

  Fly   386 STPEFYQVCHTKAAYEEYGPSICRHNPVF 414
            |...|.|:..||..|:|.||||. |...|
Human   350 SLSTFQQMWITKQEYDEAGPSIV-HRKCF 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_523968.1	ASKHA_NBD_Arp3-like	7..410	CDD:466822	152/413 (37%)
ACTA1	NP_001091.1	ASKHA_NBD_actin	8..372	CDD:466823	151/411 (37%)
		Interaction with alpha-actinin. /evidence=ECO:0000250|UniProtKB:P68135	112..125		5/12 (42%)
		Interaction with alpha-actinin. /evidence=ECO:0000250|UniProtKB:P68135	360..372		7/11 (64%)