DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp3 and POTEC

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001131143.1	Gene:	POTEC / 388468	HGNCID:	33894	Length:	542	Species:	Homo sapiens

Alignment Length:	162	Identity:	32/162 - (19%)
Similarity:	60/162 - (37%)	Gaps:	54/162 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 IQSLLREREVGIPPEQ-SLETAK--AIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKA 265
            |.:||.|:.|.:..:. |.:||:  |:...|..|| ::..::.:      |.:...|..|
Human   320 IVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVIC-ELLSDYKE------KQMLKISSEN----- 372

  Fly   266 PFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDN----VIQNCPID--VRRPLYNNIVLSGG 324
                                  |||:..:.|:...::    |.:|...:  .:.|..|
Human   373 ----------------------SNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEIN------- 408

  Fly   325 STMFKDFGRRLQRDIKRSVDTRLRISENLSEG 356
                ||..|.::.:||:.....:.:.|||:.|
Human   409 ----KDCDREVEEEIKKHGSNPVGLPENLTNG 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	32/162 (20%)
POTEC	NP_001131143.1	ANK 1	138..171
		Ank_4	143..193	CDD:290365
		ANK	167..292	CDD:238125
		ANK 2	172..201
		ANK repeat	174..203	CDD:293786
		Ank_2	177..269	CDD:289560
		ANK repeat	205..236	CDD:293786
		ANK 3	205..234
		ANK	233..357	CDD:238125	12/37 (32%)
		ANK repeat	238..269	CDD:293786
		ANK 4	238..267
		Ank_2	243..335	CDD:289560	5/14 (36%)
		ANK repeat	271..302	CDD:293786
		ANK 5	271..300
		ANK repeat	304..335	CDD:293786	5/14 (36%)
		ANK 6	304..333		5/12 (42%)
		ANK 7	337..373		10/69 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..494		19/106 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900