DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp3 and Actl6a

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001034122.1	Gene:	Actl6a / 361925	RGDID:	1307747	Length:	429	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	122/462 - (26%)
Similarity:	201/462 - (43%)	Gaps:	118/462 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ACVIDVGTGYSKLGFAGNKEPQFIIPSAIAI--------------KESARVG------DTNTRRI 51
            |.|.|:|:...:.|:||...|:...|:||.:              .:..:.|      |||..|:
  Rat    13 ALVFDIGSYTVRAGYAGEDCPKVDFPTAIGVVLERDDGSTMMEIDGDKGKQGGPTYYIDTNALRV 77

  Fly    52 TKGIEDLDFFIGDEAFDATGYSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPP 116
            .:           |:.:|..     |:::|:|||||..:..|:.....::::|...|..|::|.|
  Rat    78 PR-----------ESMEAIS-----PLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAP 126

  Fly   117 LNTPENREYTAEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVA 181
            .||...||...|:|||.:::|..::...|||...|:..|        ||:::|||...|..|||.
  Rat   127 WNTRAKREKLTELMFEHYSIPAFFLCKTAVLTAFANGRS--------TGLILDSGATHTTAIPVH 183

  Fly   182 EGYVIGSCIKHIPIAGRNITSFIQSLLREREVGIPPEQSLETAKAI----------KEK------ 230
            :|||:...|...|:||..||...:.|.:|..:.:.|...:.:.:|:          |||
  Rat   184 DGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELIPPYMIASKEAVREGSPANWKRKEKLPQVTR 248

  Fly   231 --HCYICPDIAKEF---------AKYDTEPGKWIRNFSGVNTVTKAP---------FNVDVGYER 275
              |.|:|..:.::|         :.||.:            ...:.|         :|.|.|.||
  Rat   249 SWHNYMCNCVIQDFQASVLQVSDSTYDEQ------------VAAQMPTVHYEFPNGYNCDFGAER 301

  Fly   276 FLGPEIFFHPEFSN-----PDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKDFGRRL 335
            ...||..|.|  ||     .:..:.:|.:|...:..|.||:|..||.:::::||:|:.:.|..||
  Rat   302 LKIPEGLFDP--SNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSFTDRL 364

  Fly   336 QRDIKRSVDTRLR---ISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTK 397
            .|::.:.....:|   |:.|.:..|                |::.|.|||:|||...|.|:..:|
  Rat   365 NRELSQKTPPSMRLKLIANNTTVER----------------RFSSWIGGSILASLGTFQQMWISK 413

  Fly   398 AAYEEYG 404
            ..|||.|
  Rat   414 QEYEEGG 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	122/462 (26%)
Actl6a	NP_001034122.1	Actin	11..429	CDD:394979	122/462 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910