DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Arp3 and POTED

DIOPT Version :9

Sequence 1:NP_001261559.1 Gene:Arp3 / 38898 FlyBaseID:FBgn0262716 Length:418 Species:Drosophila melanogaster
Sequence 2:NP_778146.2 Gene:POTED / 317754 HGNCID:23822 Length:584 Species:Homo sapiens


Alignment Length:420 Identity:85/420 - (20%)
Similarity:140/420 - (33%) Gaps:159/420 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PACVIDVGTGYSKLGFAGN------KEPQFIIPSAIAIKESARVGDTNTRRITKGIEDLDFFIGD 64
            |.|   .|:|.|.:|..|:      .||::.|                 ||     ||||     
Human   107 PCC---RGSGKSNVGAWGDYDHSAFMEPRYHI-----------------RR-----EDLD----- 141

  Fly    65 EAFDATGYSIKYPVRHGLV--EDWDLMERFLEQCVFKYL---RAEPEDHYFLLTEP-PLNTPENR 123
             ......:..|.|.:..:|  .|.|:.:|..|:....:|   ....|....||... .||..:|:
Human   142 -KLHRAAWWGKVPRKDLIVMLRDTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVLDNK 205

  Fly   124 EYTAEIMFETFNVPGLYIAVQ-----AVLALAASWASRS---------------------AEERT 162
            :.||           |..|:|     .||.|....|.|:                     |:...
Human   206 KRTA-----------LIKAIQCQEDECVLMLLEHGADRNIPDEYGNTALHYAIYNEDKLMAKALL 259

  Fly   163 LTGIVVDSGD--GVTHVIPVAEG------YVIGSCIKH------IPIAGRNI--------TSFIQ 205
            |.|..::|.:  |:|   |:..|      .|:...||.      :...||..        ::.|.
Human   260 LYGADIESKNKCGLT---PLLLGVHEQKQQVVKFLIKKKANLNVLDRYGRTALILAVCCGSASIV 321

  Fly   206 SLLREREVGIPPEQ-SLETAK--AIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKAPF 267
            :||.|:.|.:..:. |.:||:  |:...|..|| ::..::.:      |.:...|..|       
Human   322 NLLLEQNVDVSSQDLSGQTAREYAVSSHHHVIC-ELLSDYKE------KQMLKISSEN------- 372

  Fly   268 NVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDN----VIQNCPID--VRRPLYNNIVLSGGST 326
                                |||:..:.|:...::    |.:|...:  .:.|..|         
Human   373 --------------------SNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEIN--------- 408

  Fly   327 MFKDFGRRLQRDIKRSVDTRLRISENLSEG 356
              ||..|.::.:||:.....:.:.|||:.|
Human   409 --KDCDREVEEEIKKHGSNPVGLPENLTNG 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Arp3NP_001261559.1 PTZ00280 2..417 CDD:240343 85/420 (20%)
POTEDNP_778146.2 Ank_4 143..193 CDD:290365 9/49 (18%)
ANK 167..292 CDD:238125 28/138 (20%)
ANK 1 172..201 6/28 (21%)
ANK repeat 174..203 CDD:293786 6/28 (21%)
Ank_2 177..269 CDD:289560 21/102 (21%)
ANK repeat 205..236 CDD:293786 10/41 (24%)
ANK 2 205..234 10/39 (26%)
ANK 233..357 CDD:238125 25/127 (20%)
ANK repeat 238..269 CDD:293786 4/30 (13%)
ANK 3 238..267 3/28 (11%)
Ank_2 243..335 CDD:289560 18/94 (19%)
ANK repeat 271..302 CDD:293786 7/33 (21%)
ANK 4 271..300 7/31 (23%)
ANK repeat 304..335 CDD:293786 7/30 (23%)
ANK 5 304..333 7/28 (25%)
ANK 6 337..366 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..502 19/106 (18%)
SH3_and_anchor <440..556 CDD:275056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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