DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp3 and ACTL9

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_848620.3	Gene:	ACTL9 / 284382	HGNCID:	28494	Length:	416	Species:	Homo sapiens

Alignment Length:	416	Identity:	127/416 - (30%)
Similarity:	203/416 - (48%)	Gaps:	55/416 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGRLP----ACVIDVGTGYSKLGFAGNKEPQFIIPSAIAIKESARVGDTNTRRITKGIEDLDFF 61
            :|.|||    |.|||:|||..|:||||...|.:.:.:.:        |....:..|.|...|..|
Human    41 VADRLPPKTGAVVIDMGTGTCKVGFAGQASPTYTVATIL--------GCQPKKPATSGQSGLQTF 97

  Fly    62 IGDEAFDATGYSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYT 126
            ||:.|......::..|:|.|:|.|||..|......:...||....||..|.::||.:...|||..
Human    98 IGEAARVLPELTLVQPLRSGIVVDWDAAELIWRHLLEHDLRVATHDHPLLFSDPPFSPATNREKL 162

  Fly   127 AEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIK 191
            .|:.||:...|.:|:|.|:||::.|        ...::|:|||:|.|||:.:||.:||.:....:
Human   163 VEVAFESLRSPAMYVASQSVLSVYA--------HGRVSGLVVDTGHGVTYTVPVFQGYNLLHATE 219

  Fly   192 HIPIAGRNITSFIQSLLREREVGIP-PEQSLETAKAIKEKHCYICPDIAKEFAKYDTEPGKWIRN 255
            .:.:||.|:|:|:..:|  .:.|:| .:|.|:..:.||..:||:..|..||.|:.:.|..:.::.
Human   220 RLDLAGNNLTAFLAEML--LQAGLPLGQQDLDLVENIKHHYCYVASDFQKEQARPEQEYKRTLKL 282

  Fly   256 FSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDF----TIPLSEIVDNVIQNCPIDVRRPLY 316
            ..| .|||       :|.|.|..||:.|:|    |:.    .:.||.:....::...:::|..|.
Human   283 PDG-RTVT-------LGKELFQCPELLFNP----PEVPGLSPVGLSTMAKQSLRKLSLEMRADLA 335

  Fly   317 NNIVLSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGG 381
            .|::|.|||::|..|..|.:.::.|::                |....|.|.....:.::||.||
Human   336 QNVLLCGGSSLFTGFEGRFRAELLRAL----------------PAETHVVVAAQPTRNFSVWIGG 384

  Fly   382 SMLASTPEFYQVCHTKAAYEEYGPSI 407
            |:|||...|......:..|||.||.|
Human   385 SILASLRAFQSCWVLREQYEEQGPYI 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	127/415 (31%)
ACTL9	NP_848620.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		NBD_sugar-kinase_HSP70_actin	49..416	CDD:302596	123/408 (30%)
		ACTIN	49..415	CDD:214592	123/408 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910