DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp3 and POTEH

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001129685.1	Gene:	POTEH / 23784	HGNCID:	133	Length:	545	Species:	Homo sapiens

Alignment Length:	162	Identity:	33/162 - (20%)
Similarity:	61/162 - (37%)	Gaps:	54/162 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 IQSLLREREVGIPPEQ-SLETAK--AIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKA 265
            |.|||.|:.:.:..:. |.:||:  |:..:|..|| .:..::.:      |.|...|..|
Human   357 IVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVIC-QLLSDYKE------KQILKVSSEN----- 409

  Fly   266 PFNVDVGYERFLGPEIFFHPEFSNPDFTIPL-----SEIVDNVIQNCPIDV-RRPLYNNIVLSGG 324
                                  |||:..:.|     |:.:.....:.|.:: :.|..|    .||
Human   410 ----------------------SNPEQDLKLTSEEESQRLKGSENSQPEEMSQEPEIN----KGG 448

  Fly   325 STMFKDFGRRLQRDIKRSVDTRLRISENLSEG 356
            .       |:::.::|:...|.:...|||:.|
Human   449 D-------RKVEEEMKKHGSTHMGFPENLTNG 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	33/162 (20%)
POTEH	NP_001129685.1	Ank_4	180..230	CDD:290365
		ANK 1	180..208
		ANK	204..329	CDD:238125
		ANK 2	209..238
		ANK repeat	211..240	CDD:293786
		Ank_2	214..306	CDD:289560
		ANK repeat	242..273	CDD:293786
		ANK 3	242..271
		ANK	270..394	CDD:238125	12/37 (32%)
		ANK repeat	275..306	CDD:293786
		ANK 4	275..304
		Ank_2	280..372	CDD:289560	5/14 (36%)
		ANK repeat	308..339	CDD:293786
		ANK 5	308..337
		ANK repeat	341..372	CDD:293786	5/14 (36%)
		ANK 6	341..370		5/12 (42%)
		ANK 7	374..404		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..524		19/106 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900