DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp3 and ACTL7A

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_006678.1	Gene:	ACTL7A / 10881	HGNCID:	161	Length:	435	Species:	Homo sapiens

Alignment Length:	419	Identity:	127/419 - (30%)
Similarity:	199/419 - (47%)	Gaps:	82/419 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ACVIDVGTGYSKLGFAGNKEPQFIIPSAIA--IKESARVGDTNTRRITKGIEDLDFFIGDEAFDA 69
            |.|:|:||||.|.||||...|...|.:.:.  ..|:|:.||  .|:.|        |:|.| .:.
Human    71 AVVVDLGTGYCKCGFAGLPRPTHKISTTVGKPYMETAKTGD--NRKET--------FVGQE-LNN 124

  Fly    70 TGYSIKY--PVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFE 132
            |...:|.  |:|||::.|||.::...|....:.::..||:|..|:::|||:...|||..||::||
Human   125 TNVHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFE 189

  Fly   133 TFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAG 197
            .||.|.::||.|:.|       |..:..|| :|:||:.|.||::|:|:.|||.:.|....:..||
Human   190 AFNTPAMHIAYQSRL-------SMYSYGRT-SGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAG 246

  Fly   198 RNITSFIQSLLR-------EREVGIPPEQSLETAKAIKEKHCYICPD--------IAKEFAKYDT 247
            .::|:::..||.       :.::||        .:.||:|.|::..|        :::...:|..
Human   247 SDLTAYLLGLLNSAGNEFTQDQMGI--------VEDIKKKCCFVALDPIEEKKVPLSEHTIRYVL 303

  Fly   248 EPGKWIRNFSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVR 312
            ..||                .:.:..||||..|:||.|.... ...:.|.....:.:..|.|.::
Human   304 PDGK----------------EIQLCQERFLCSEMFFKPSLIK-SMQLGLHTQTVSCLNKCDIALK 351

  Fly   313 RPLYNNIVLSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQR-YA 376
            |.|..||:|.|||||...|..|||:::....                  |.|...:....:| .|
Human   352 RDLMGNILLCGGSTMLSGFPNRLQKELSSMC------------------PNDTPQVNVLPERDSA 398

  Fly   377 VWFGGSMLASTPEFYQVCHTKAAYEEYGP 405
            ||.|||:|||...|..:...:..|||:||
Human   399 VWTGGSILASLQGFQPLWVHRFEYEEHGP 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	127/419 (30%)
ACTL7A	NP_006678.1	ACTL7A_N	1..65	CDD:293445
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		Required for interaction with TES	31..51
		NBD_sugar-kinase_HSP70_actin	67..435	CDD:302596	127/419 (30%)
		ACTIN	69..435	CDD:214592	127/419 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810