DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp3 and POTEB2

DIOPT Version :9

Sequence 1:	NP_001261559.1	Gene:	Arp3 / 38898	FlyBaseID:	FBgn0262716	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001264232.1	Gene:	POTEB2 / 100287399	HGNCID:	48327	Length:	544	Species:	Homo sapiens

Alignment Length:	162	Identity:	32/162 - (19%)
Similarity:	60/162 - (37%)	Gaps:	54/162 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 IQSLLREREVGIPPEQ-SLETAK--AIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKA 265
            |.:||.|:.|.:..:. |.:||:  |:...|..|| ::..::.:      |.:...|..|
Human   283 IVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVIC-ELLSDYKE------KQMLKISSEN----- 335

  Fly   266 PFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDN----VIQNCPID--VRRPLYNNIVLSGG 324
                                  |||:..:.|:...::    |.:|...:  .:.|..|
Human   336 ----------------------SNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEIN------- 371

  Fly   325 STMFKDFGRRLQRDIKRSVDTRLRISENLSEG 356
                ||..|.::.:||:.....:.:.|||:.|
Human   372 ----KDCDREVEEEIKKHGSNPVGLPENLTNG 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp3	NP_001261559.1	PTZ00280	2..417	CDD:240343	32/162 (20%)
POTEB2	NP_001264232.1	ANK	130..255	CDD:238125
		ANK 1	135..167
		ANK repeat	137..166	CDD:293786
		ANK 2	168..200
		ANK repeat	168..199	CDD:293786
		ANK	196..320	CDD:238125	12/37 (32%)
		ANK 3	201..233
		ANK repeat	201..232	CDD:293786
		ANK 4	234..266
		ANK repeat	234..265	CDD:293786
		ANK 5	267..299		5/15 (33%)
		ANK repeat	267..298	CDD:293786	5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..457		19/106 (18%)
		SMC_N	<412..>542	CDD:330553
		CCDC144C	489..>542	CDD:317340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900