Protein Alignment Nulp1 and RQC1

DIOPT Version :10

• Sequence 1: NP_648174.3
• Gene: Nulp1 / 38897
• FlyBaseID: FBgn0027549
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_010620.3
• Gene: RQC1 / 851933
• SGDID: S000002741
• Length: 723
• Species: Saccharomyces cerevisiae
• Alignment Length: 699
• Identity: 163/699 - (23%)
• Similarity: 274/699 - (39%)
• Gaps: 161/699 - (23%)

  Fly     1 MSARMLKKLQGDADKLAPPPDDEDCEELSDNDELEDSDMQRYRKSHLNPFDLLN---QAGLSLSE 62
            ||:|.|::||.|...|.....:.:..:::.......:..:|.     |.|.::|   .:..|..|
Yeast     1 MSSRALRRLQDDNALLESLLSNSNANKMTSGKSTAGNIQKRE-----NIFSMMNNVRDSDNSTDE 60

  Fly    63 SEFKEDDNET------EHPSAALPNATASAAKKKKKKRKKKAK-SSGNHIS----------SEDN 110
            .:..|.|.|.      :..|...|.....|:|..::|:.|||| ...||.:          .:|:
Yeast    61 GQMSEQDEEAAAAGERDTQSNGQPKRITLASKSSRRKKNKKAKRKQKNHTAEAAKDKGSDDDDDD 125

  Fly   111 ERQDK---YFEKVDPL-LGKVYD-----------AVPRQSA----KQLVSAATGTTATK------ 150
            |..||   .|:|.|.| .||..:           :.|.:::    |..:|..:....||
Yeast   126 EEFDKIIQQFKKTDILKYGKTKNDDTNEEGFFTASEPEEASSQPWKSFLSLESDPGFTKFPISCL 190

  Fly   151 ----KLLAVELRHLNPQNEMRRTFG-----------------------------KRVVK------ 176
                |....:.:.|:|..|.:..|.                             ||:::
Yeast   191 RHSCKFFQNDFKKLDPHTEFKLLFDDISPESLEDIDSMTSTPVSPQQLKQIQRLKRLIRNWGGKD 255

  Fly   177 ---VETKRGRQKPTLKSTYMVTAKDSWPALTKNTITMKLLPAPD-------SPSVSSKSITDNGA 231
               .....|.....||.|.:   :|.|....:..::||||.:.|       ...:..|.:..|
Yeast   256 HRLAPNGPGMHPQHLKFTKI---RDDWIPTQRGELSMKLLSSDDLLDWQLWERPLDWKDVIQN-- 315

  Fly   232 DV-QWFAFEHSQYY-----------QGVQQMFLSALERIDSEFLITLI-KRCPYHVDSLVQLSEV 283
            || ||..|  ..:|           :.:...:||.:...|.|.||.|| .:.||||..|:|::.:
Yeast   316 DVSQWQKF--ISFYKFEPLNSDLSKKSMMDFYLSVIVHPDHEALINLISSKFPYHVPGLLQVALI 378

  Fly   284 CKMTEDFSLASELLERALLLLESSLHINFSLTSGNCRLDYRRQENRSFYIVLFKHAQYLEERACS 348
            .....|.|..:.||:|||.:.:.:|..|....|.||:|.|....||.||:.:|::.|.|.:|...
Yeast   379 FIRQGDRSNTNGLLQRALFVFDRALKANIIFDSLNCQLPYIYFFNRQFYLAIFRYIQSLAQRGVI 443

  Fly   349 RTAFEISKLLLSLQPDTDPLAMILVIDYYALRSKQFEWLVEF--------YEKYNAARNLNQLPN 405
            .||.|.:|:|.||.|..|||.....:|:|.|.:..:::::|.        |:::|         .
Yeast   444 GTASEWTKVLWSLSPLEDPLGCRYFLDHYFLLNNDYQYIIELSNSPLMNCYKQWN---------T 499

  Fly   406 MAYSYALALHTL-YGACERSNQALQYALLMFPGVLRPLLDEMSVQTDKRVLASSYFFADVSGNQS 469
            :.:|.|:.|..| ......:..||..|....|..|..|..|       ::|.......|:|.:..
Yeast   500 LGFSLAVVLSFLRINEMSSARNALLKAFKHHPLQLSELFKE-------KLLGDHALTKDLSIDGH 557

  Fly   470 PALHQLVCLYVCRARVVWRQNEVLPWLESNV----------NIVLDRIESKDPLVNEYKEKRSLR 524
            .|.:..:..|:.|..::|.:||.:.:|...:          |:.:|..:.:|.  |.....:|..
Yeast   558 SAENLELKAYMARFPLLWNRNEEVTFLHDEMSSILQDYHRGNVTIDSNDGQDH--NNINNLQSPF 620

  Fly   525 YSGTPPRPILRHVILSDYKEKVPLAV--FVSKEKQAIMTYDPLPP-PNS 570
            :....|..:||..|||: :..|..|:  |:..:.: :..:|.||| |.|
Yeast   621 FIAGIPINLLRFAILSE-ESSVMAAIPSFIWSDNE-VYEFDVLPPMPTS 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nulp1	NP_648174.3	Tcf25	236..567	CDD:461476	92/363 (25%)
RQC1	NP_010620.3	Tcf25	327..663	CDD:461476	91/355 (26%)