Protein Alignment Nulp1 and Tcf25

DIOPT Version :10

• Sequence 1: NP_648174.3
• Gene: Nulp1 / 38897
• FlyBaseID: FBgn0027549
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_006531359.1
• Gene: Tcf25 / 66855
• MGIID: 1914105
• Length: 682
• Species: Mus musculus
• Alignment Length: 754
• Identity: 263/754 - (34%)
• Similarity: 395/754 - (52%)
• Gaps: 127/754 - (16%)

  Fly     1 MSARMLKKLQGD---ADKLAPPP------DDEDCE---------------------------ELS 29
            ||.|.|::|:|:   .:.|.|..      ||:|.|                           ||.
Mouse     1 MSRRALRRLRGEQRGQEPLGPDALKFVLLDDDDAEEEGPKPGLGGRRPGGAGKEGVRVNNRFELI 65

  Fly    30 DNDELEDSDMQRYRKSHLNPFDLL---NQAGLSLSESEFKEDDNETEHPSAALPNATASAAKKKK 91
            :.::|||..:....:|.....|.:   |:.......:|.|:|...|:..|:...||:....||||
Mouse    66 NTEDLEDDLVVNGERSDCTLPDSVSSGNKGRAKHGNAETKQDGGATKAGSSEQSNASGKLRKKKK 130

  Fly    92 KKRKKKA---KSSGNHISSEDNERQDKYFEKVDPLLGKVYDAVPRQSAKQLVSAATGTTATKKLL 153
            |::.||:   :||.|.:     |..|:..|:::...|..:...|..|::            |.:|
Mouse   131 KQKNKKSCTGESSENGL-----EDIDRILERIEDSSGFSHPGPPPLSSR------------KHVL 178

  Fly   154 AVELRHLNPQNEMRRTFGKRVVKVETK-RGRQKPTLKSTYMVTAKDSWPALTKNTITMKLLPAPD 217
            .||.|||||..|::|.||.|.|..|.: |.||:...|.|::.|.|.:||..:|..::|:||.
Mouse   179 YVEHRHLNPDTELKRYFGARAVLGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLE--- 240

  Fly   218 SPSVSSKSITDNGADVQWFAFEHSQYYQGVQQMFLSALERIDSEFLITLIKRCPYHVDSLVQLSE 282
                |.|.::       :|||:|::.||..|..||.|:|.::...::.|::..|||||||:|||:
Mouse   241 ----SKKGLS-------FFAFDHNEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSD 294

  Fly   283 VCKMTEDFSLASELLERALLLLESSLHINFSLTSGNCRLDYRRQENRSFYIVLFKHAQYLEERAC 347
            .|:..||..:|.:|:||||..:|.:.|..||||||.|||||||.||||||:.|:|...:||:|.|
Mouse   295 ACRFQEDQEMARDLIERALYSMECAFHPLFSLTSGTCRLDYRRPENRSFYLTLYKQMSFLEKRGC 359

  Fly   348 SRTAFEISKLLLSLQPDTDPLAMILVIDYYALRSKQFEWLVEFYEKYNAARNLNQLPNMAYSYAL 412
            .|||.|..||:|||:||.|||.|:|:||:.|||::.:|:|:..::::.|.|||:||||.|:|..|
Mouse   360 PRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPL 424

  Fly   413 AL-----------HTLYGACERSNQALQYALLMFPGVLRPLLDEMSVQTDKRVLASSYFFADVSG 466
            |.           |.|..|.::::..:|.||.||||||.|||:..||:.|..|....:|..|...
Mouse   425 AYFLLSQQTDLPEHELSSARQQASLLIQQALTMFPGVLMPLLEYCSVRPDATVSNHRFFGPDAEI 489

  Fly   467 NQSPALHQLVCLYVCRARVVWRQNEVLPWLESNVNIVLDRIESKDPLVNEYKEKRSLRYSGTPPR 531
            :|.|||.|||.||:.|:..:|::..::.|||.||:.||..:::.||.|...:.:|.:.|. ..||
Mouse   490 SQPPALGQLVSLYLGRSHFLWKEPAIMSWLEENVHEVLQAVDAGDPAVEACENRRKVLYQ-RAPR 553

  Fly   532 PILRHVILSDYKEKVPLAVFVSKEKQAIMTYDPLPPPNSVNCYHRKSSSSSSPTTNTNNSVSMFF 596
            .|.||||||:.||.| .|:......|::|.:|||||.:::..|.|  ....||.:: .|::::||
Mouse   554 NIHRHVILSEIKEAV-AALPSDVTTQSVMGFDPLPPLDTIYSYVR--PERLSPVSH-GNTIALFF 614

  Fly   597 QSLLPSFNINNLAANAQLQEGAAPAAGAGAAAGDANIEVGIEQGAAGVAGEGEEAGLQQSLTLMM 661
            :||||::. ..|....|.:.                    :|:|.||  |.....||.:    :|
Mouse   615 RSLLPNYT-TELCLIVQGER--------------------LEEGVAG--GPNRNQGLNR----LM 652

  Fly   662 DAMRDFLQNFRIAEHLRSPETAAAQSTSSNDEEEGSSDY 700
            .|:||.:.||...: |..|.         .|..||..|:
Mouse   653 LAVRDMMANFHFND-LEVPR---------EDNPEGEGDW 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nulp1	NP_648174.3	Tcf25	236..567	CDD:461476	155/341 (45%)
Tcf25	XP_006531359.1	Tcf25	248..588	CDD:461476	155/341 (45%)