Protein Alignment Nulp1 and TCF25

DIOPT Version :10

• Sequence 1: NP_648174.3
• Gene: Nulp1 / 38897
• FlyBaseID: FBgn0027549
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_055787.1
• Gene: TCF25 / 22980
• HGNCID: 29181
• Length: 676
• Species: Homo sapiens
• Alignment Length: 766
• Identity: 267/766 - (34%)
• Similarity: 403/766 - (52%)
• Gaps: 157/766 - (20%)

  Fly     1 MSARMLKKLQGD---ADKLAPPP------DDEDCEELSDNDEL-----EDSDMQRYRKSHLNPFD 51
            ||.|.|::|:|:   .:.|.|..      ||:|.||.....||     ..:..:..|.:  |.|:
Human     1 MSRRALRRLRGEQRGQEPLGPGALHFDLRDDDDAEEEGPKRELGVRRPGGAGKEGVRVN--NRFE 63

  Fly    52 LLN-------------QAGLSLSE--------------SEFKEDDNETEHPSAALPNATASAA-- 87
            |:|             ::|.:|::              :|.|.|.::||    .:|:..:.|:
Human    64 LINIDDLEDDPVVNGERSGCALTDAVAPGNKGRGQRGNTESKTDGDDTE----TVPSEQSHASGK 124

  Fly    88 -KKKKKKRKKKAKSSGNHISSEDNERQDKYFEKVDPLLGKVYDAVPRQSAKQLVSAATG------ 145
             :|||||:|.|..|:|        |..:...|.:|.:|.::.|             :||
Human   125 LRKKKKKQKNKKSSTG--------EASENGLEDIDRILERIED-------------STGLNRPGP 168

  Fly   146 --TTATKKLLAVELRHLNPQNEMRRTFGKRVVKVETK-RGRQKPTLKSTYMVTAKDSWPALTKNT 207
              .::.|.:|.||.|||||..|::|.||.|.:..|.: |.||:...|.|::.|.|.:||..:|..
Human   169 APLSSRKHVLYVEHRHLNPDTELKRYFGARAILGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPG 233

  Fly   208 ITMKLLPAPDSPSVSSKSITDNGADVQWFAFEHSQYYQGVQQMFLSALERIDSEFLITLIKRCPY 272
            ::|:||.       |.|.::       :||||||:.||..|..||.|:|.::...::.|::..||
Human   234 LSMRLLE-------SKKGLS-------FFAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPY 284

  Fly   273 HVDSLVQLSEVCKMTEDFSLASELLERALLLLESSLHINFSLTSGNCRLDYRRQENRSFYIVLFK 337
            |||||:|||:.|:..||..:|.:|:||||..:|.:.|..||||||.|||||||.||||||:.|:|
Human   285 HVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLTSGACRLDYRRPENRSFYLALYK 349

  Fly   338 HAQYLEERACSRTAFEISKLLLSLQPDTDPLAMILVIDYYALRSKQFEWLVEFYEKYNAARNLNQ 402
            ...:||:|.|.|||.|..||:|||:||.|||.|:|:||:.|||::.:|:|:..::::.|.|||:|
Human   350 QMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQ 414

  Fly   403 LPNMAYSYALALHTL-----YGACERSNQ------ALQYALLMFPGVLRPLLDEMSVQTDKRVLA 456
            |||.|:|..||...|     ...||:|:.      .:|.||.||||||.|||:..||:.|..|.:
Human   415 LPNFAFSVPLAYFLLSQQTDLPECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSS 479

  Fly   457 SSYFFADVSGNQSPALHQLVCLYVCRARVVWRQNEVLPWLESNVNIVLDRIESKDPLVNEYKEKR 521
            ..:|..:...:|.|||.|||.||:.|:..:|::...:.|||.||:.||..:::.||.|...:.:|
Human   480 HRFFGPNAEISQPPALSQLVNLYLGRSHFLWKEPATMSWLEENVHEVLQAVDAGDPAVEACENRR 544

  Fly   522 SLRYSGTPPRPILRHVILSDYKEKVPLAVFVSKEKQAIMTYDPLPPPNSVNCYHRKSSSSSSPTT 586
            .:.|. ..||.|.||||||:.||.| .|:......|::|.:|||||.:::..|.|  ....||.:
Human   545 KVLYQ-RAPRNIHRHVILSEIKEAV-AALPPDVTTQSVMGFDPLPPSDTIYSYVR--PERLSPIS 605

  Fly   587 NTNNSVSMFFQSLLPSFNINNLAANAQLQEGAAPAAGAGAAAGDANIEVGIEQGAAGVAGEGEEA 651
            : .|::::||:||||::.:          ||..|                 |:|.||
Human   606 H-GNTIALFFRSLLPNYTM----------EGERP-----------------EEGVAG-------- 634

  Fly   652 GL--QQSLTLMMDAMRDFLQNFRIAEHLRSPETAAAQSTSSNDEEEGSSDY 700
            ||  .|.|..:|.|:||.:.||.:.: |.:|.         .|:.||..::
Human   635 GLNRNQGLNRLMLAVRDMMANFHLND-LEAPH---------EDDAEGEGEW 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nulp1	NP_648174.3	Tcf25	236..567	CDD:461476	157/341 (46%)
TCF25	NP_055787.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		16/57 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	85..147		18/73 (25%)
		Tcf25	248..588	CDD:461476	157/341 (46%)