Protein Alignment Sarm and sarm1

DIOPT Version :10

• Sequence 1: NP_001246662.1
• Gene: Sarm / 38895
• FlyBaseID: FBgn0262579
• Length: 1730
• Species: Drosophila melanogaster
• Sequence 2: XP_002937189.2
• Gene: sarm1 / 779619
• XenbaseID: XB-GENE-6033913
• Length: 719
• Species: Xenopus tropicalis
• Alignment Length: 633
• Identity: 297/633 - (46%)
• Similarity: 414/633 - (65%)
• Gaps: 17/633 - (2%)

  Fly   718 LEKINEVIRRAWAVPTHGHELGYSLCNSLRQSGGLDLLMK--NCVKPDLQFSSAQLLEQCLTTEN 780
            :.:|.:::..||.:|..|.|:...||.:||..|.||.|:.  ...:..:::.:.|||||.|..:|
 Frog    87 IAEIFQMVEEAWVMPAVGREVAQGLCETLRLEGALDRLLSLLQSSEASVKYQACQLLEQVLVADN 151

  Fly   781 RKHVVDNGLDKVVNVACVCTKN-SNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLFECRT 844
            |..:...||..|:|:    ||. .:...:|...|||||:|||||.|||.::..|||:.:||.||.
 Frog   152 RDRIARIGLGVVLNL----TKELGDPRLARSLCGILEHMFKHSEETCSQLVCNGGLEYILFWCRW 212

  Fly   845 SDLETLRHCASALANLSLYGGAENQEEMILRKVPMWLFPLAF-HNDDNIKYYACLAIAVLVANKE 908
            :|...|||||.||||.::|||..||..||.::...||||||| ..||.|:::|||||.||..|||
 Frog   213 TDPVVLRHCAVALANCAMYGGPCNQHLMIDKRAAEWLFPLAFSKEDDLIRFHACLAITVLATNKE 277

  Fly   909 IEAEVLKSGCLDLVEPFVTSHDPSAFARSNL---AHAHGQSKHWLKRLVPVLSSNREEARNLAAF 970
            ||.:|.:||.|.|||||::|.||..||||.|   .:..|::...|:||||:|.|:|.||:.:|||
 Frog   278 IEKDVERSGTLALVEPFISSLDPKEFARSLLDSSDNTQGRTGDDLQRLVPLLDSSRLEAQCIAAF 342

  Fly   971 HFCMEAGIKREQGNTDIFREINAIEALKN-VASCPNAIASKFAAQALRLIGETVPHKLSQQVPLW 1034
            :.|:|..||.:|.|..:|.||.|.::|:. |..|.:...|..|.:||:::||.||.::::.||.|
 Frog   343 YLCVEVAIKCQQKNIKLFNEIGATQSLRRIVCYCADGTVSSLAKRALQMMGEEVPRRIARSVPNW 407

  Fly  1035 SVEDVQEWVKQIGFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMA 1099
            ...:||.|::||||::|.:.|.|:|:||||||:|....||.|:.:.:.|..|||.|||..||..|
 Frog   408 KPLEVQHWLQQIGFSNYSENFLENQIDGDLLLRLTMSELRDDLNMTSSITRKRFMRELVELKTFA 472

  Fly  1100 DYSSKDTAKMHQFLSEIGTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAV 1164
            :||:.|.:.:..:|..:...:..|||.::.||||:..|.||.|..|..:|.|....||:.||:|.
 Frog   473 NYSTCDRSNLADWLGSVDPRFRQYTYNLVTAGIDRNFLHHVTEQQLEEDCHISIGFHRVCILSAA 537

  Fly  1165 KN-LENSLPSSSEENMAKTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGL 1228
            :. |.:.||.|..::.|...|||:|||||.||||||||||||.||||:.|||||:||||||::.|
 Frog   538 REMLHSPLPCSVGKSSADGPDVFISYRRSTGSQLASLLKVHLYLRGFTAFIDVEKLEAGKFEDKL 602

  Fly  1229 LNSIRQAKNFVLVLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPED 1293
            |:|:..|:||||:|:..||.:|:.|.|||||||:|||.|||::.||||:.| .|:||:...||||
 Frog   603 LHSVISARNFVLILSAKALDKCMGDNDCKDWVHKEIVTALNNSKNIIPVTD-HFEWPDPMTLPED 666

  Fly  1294 MRSVAHFNGVNWIHDYQDACIDKLERFLRGEKNIDRIAA---MVPGTP 1338
            ||:|..|||:.|.|:||||.::|:.|||:|..:.|..|.   .:.|||
 Frog   667 MRAVLKFNGIKWSHEYQDATVEKIIRFLQGRSSRDSSAGSEISLDGTP 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sarm	NP_001246662.1	SARM1_N	716..1021	CDD:467946	136/310 (44%)
		SAM_SARM1-like_repeat1	1031..1099	CDD:188900	33/67 (49%)
		SAM_SARM1-like_repeat2	1100..1169	CDD:188901	24/69 (35%)
		TIR	1184..1321	CDD:214587	87/136 (64%)
sarm1	XP_002937189.2	SARM1_N	83..394	CDD:467946	136/310 (44%)
		SAM_SARM1-like_repeat1	404..472	CDD:188900	33/67 (49%)
		SAM_SARM1-like_repeat2	473..542	CDD:188901	23/68 (34%)
		TIR	557..697	CDD:214587	89/140 (64%)