Protein Alignment Sarm and SARM1

DIOPT Version :10

• Sequence 1: NP_001246662.1
• Gene: Sarm / 38895
• FlyBaseID: FBgn0262579
• Length: 1730
• Species: Drosophila melanogaster
• Sequence 2: NP_055892.2
• Gene: SARM1 / 23098
• HGNCID: 17074
• Length: 724
• Species: Homo sapiens
• Alignment Length: 676
• Identity: 311/676 - (46%)
• Similarity: 436/676 - (64%)
• Gaps: 27/676 - (3%)

  Fly   666 KSLTAGSGQQEIEQTINKYSNMLTSIVSSLQEDERGGSAITVHDVGGKKSQYLEKINEVIRRAWA 730
            :.::.|:| .|::..:.:....|...:|:|:  :.||:    ..||..    |.::.:::..||.
Human    51 REVSPGAG-TEVQDALERALPELQQALSALK--QAGGA----RAVGAG----LAEVFQLVEEAWL 104

  Fly   731 VPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPDLQ--FSSAQLLEQCLTTENRKHVVDNGLDKVV 793
            :|..|.|:...||:::|..||||||::....|:|:  ..:|:||||.|..|||..|...||..::
Human   105 LPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVIL 169

  Fly   794 NVACVCTKNSNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALA 858
            |:|   .:...:|.:|...|||||:|||||.||..::..|||||||:.||.:|...|||||.||.
Human   170 NLA---KEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALG 231

  Fly   859 NLSLYGGAENQEEMILRKVPMWLFPLAFHNDDN-IKYYACLAIAVLVANKEIEAEVLKSGCLDLV 922
            |.:|:||...|..|:.::...|||||||..:|. ::.:||||:|||..|||:|.||.:||.|.||
Human   232 NCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALV 296

  Fly   923 EPFVTSHDPSAFAR-----SNLAHAHGQSKHWLKRLVPVLSSNREEARNLAAFHFCMEAGIKREQ 982
            ||.|.|.||..|||     |:.:...|...  |:||||:|.|||.||:.:.||:.|.||.||..|
Human   297 EPLVASLDPGRFARCLVDASDTSQGRGPDD--LQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQ 359

  Fly   983 GNTDIFREINAIEALKNVAS-CPNAIASKFAAQALRLIGETVPHKLSQQVPLWSVEDVQEWVKQI 1046
            |.|.:|.:|.||::||.:.| ..|...|..|.:||||:||.||..:...||.|...:||.|::||
Human   360 GKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQI 424

  Fly  1047 GFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMADYSSKDTAKMHQ 1111
            ||:.|.:.|.|.||||||||:|.::.|:.|:|:.:||..|||.|||..||..|:||:.|.:.:..
Human   425 GFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLAD 489

  Fly  1112 FLSEIGTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAVKN-LENSLPSSS 1175
            :|..:...:..|||.:::.|:|:..|..|:|..|:.:||||..:||.|||.|.:. |.:.||.:.
Human   490 WLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTG 554

  Fly  1176 EENMAKTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLLNSIRQAKNFVL 1240
            .:....|.|||:||||::||||||||||||||.|||||||||:||||||::.|:.|:..|:||||
Human   555 GKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVL 619

  Fly  1241 VLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPEDMRSVAHFNGVNW 1305
            ||:|.||.:|:.|.|||||||:|||.||:...||:|||| .|:|||.:.|||||::|..|||:.|
Human   620 VLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIID-GFEWPEPQVLPEDMQAVLTFNGIKW 683

  Fly  1306 IHDYQDACIDKLERFLRGEKNIDRIA 1331
            .|:||:|.|:|:.|||:|..:.|..|
Human   684 SHEYQEATIEKIIRFLQGRSSRDSSA 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sarm	NP_001246662.1	SARM1_N	716..1021	CDD:467946	140/313 (45%)
		SAM_SARM1-like_repeat1	1031..1099	CDD:188900	35/67 (52%)
		SAM_SARM1-like_repeat2	1100..1169	CDD:188901	24/69 (35%)
		TIR	1184..1321	CDD:214587	89/136 (65%)
SARM1	NP_055892.2	ARM 1. /evidence=ECO:0000255	60..100		9/49 (18%)
		SARM1_N	94..399	CDD:467946	139/309 (45%)
		ARM 2. /evidence=ECO:0000255	114..153		16/38 (42%)
		ARM 3. /evidence=ECO:0000255	155..193		15/40 (38%)
		ARM 4. /evidence=ECO:0000255	196..235		21/38 (55%)
		ARM 5. /evidence=ECO:0000255	237..280		19/42 (45%)
		ARM 6. /evidence=ECO:0000255	281..314		19/32 (59%)
		ARM 7. /evidence=ECO:0000255	315..354		17/40 (43%)
		ARM 8. /evidence=ECO:0000255	359..402		19/42 (45%)
		SAM_SARM1-like_repeat1	409..477	CDD:188900	35/67 (52%)
		SAM_SARM1-like_repeat2	478..547	CDD:188901	23/68 (34%)
		TIR	561..702	CDD:214587	92/141 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..724		2/6 (33%)