DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sarm and SARM1

DIOPT Version :9

Sequence 1:NP_001246662.1 Gene:Sarm / 38895 FlyBaseID:FBgn0262579 Length:1730 Species:Drosophila melanogaster
Sequence 2:NP_055892.2 Gene:SARM1 / 23098 HGNCID:17074 Length:724 Species:Homo sapiens


Alignment Length:676 Identity:311/676 - (46%)
Similarity:436/676 - (64%) Gaps:27/676 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly   666 KSLTAGSGQQEIEQTINKYSNMLTSIVSSLQEDERGGSAITVHDVGGKKSQYLEKINEVIRRAWA 730
            :.::.|:| .|::..:.:....|...:|:|:  :.||:    ..||..    |.::.:::..||.
Human    51 REVSPGAG-TEVQDALERALPELQQALSALK--QAGGA----RAVGAG----LAEVFQLVEEAWL 104

  Fly   731 VPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPDLQ--FSSAQLLEQCLTTENRKHVVDNGLDKVV 793
            :|..|.|:...||:::|..||||||::....|:|:  ..:|:||||.|..|||..|...||..::
Human   105 LPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVIL 169

  Fly   794 NVACVCTKNSNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALA 858
            |:|   .:...:|.:|...|||||:|||||.||..::..|||||||:.||.:|...|||||.||.
Human   170 NLA---KEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALG 231

  Fly   859 NLSLYGGAENQEEMILRKVPMWLFPLAFHNDDN-IKYYACLAIAVLVANKEIEAEVLKSGCLDLV 922
            |.:|:||...|..|:.::...|||||||..:|. ::.:||||:|||..|||:|.||.:||.|.||
Human   232 NCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALV 296

  Fly   923 EPFVTSHDPSAFAR-----SNLAHAHGQSKHWLKRLVPVLSSNREEARNLAAFHFCMEAGIKREQ 982
            ||.|.|.||..|||     |:.:...|...  |:||||:|.|||.||:.:.||:.|.||.||..|
Human   297 EPLVASLDPGRFARCLVDASDTSQGRGPDD--LQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQ 359

  Fly   983 GNTDIFREINAIEALKNVAS-CPNAIASKFAAQALRLIGETVPHKLSQQVPLWSVEDVQEWVKQI 1046
            |.|.:|.:|.||::||.:.| ..|...|..|.:||||:||.||..:...||.|...:||.|::||
Human   360 GKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQI 424

  Fly  1047 GFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMADYSSKDTAKMHQ 1111
            ||:.|.:.|.|.||||||||:|.::.|:.|:|:.:||..|||.|||..||..|:||:.|.:.:..
Human   425 GFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLAD 489

  Fly  1112 FLSEIGTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAVKN-LENSLPSSS 1175
            :|..:...:..|||.:::.|:|:..|..|:|..|:.:||||..:||.|||.|.:. |.:.||.:.
Human   490 WLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTG 554

  Fly  1176 EENMAKTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLLNSIRQAKNFVL 1240
            .:....|.|||:||||::||||||||||||||.|||||||||:||||||::.|:.|:..|:||||
Human   555 GKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVL 619

  Fly  1241 VLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPEDMRSVAHFNGVNW 1305
            ||:|.||.:|:.|.|||||||:|||.||:...||:|||| .|:|||.:.|||||::|..|||:.|
Human   620 VLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIID-GFEWPEPQVLPEDMQAVLTFNGIKW 683

  Fly  1306 IHDYQDACIDKLERFLRGEKNIDRIA 1331
            .|:||:|.|:|:.|||:|..:.|..|
Human   684 SHEYQEATIEKIIRFLQGRSSRDSSA 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SarmNP_001246662.1 SAM_SARM1-like_repeat1 1031..1099 CDD:188900 35/67 (52%)
SAM 1031..1096 CDD:197735 33/64 (52%)
SAM_SARM1-like_repeat2 1100..1169 CDD:188901 24/69 (35%)
SAM 1111..1170 CDD:197735 21/59 (36%)
TIR_2 1185..1285 CDD:290400 68/99 (69%)
SARM1NP_055892.2 ARM 1. /evidence=ECO:0000255 60..100 9/49 (18%)
ARM 2. /evidence=ECO:0000255 114..153 16/38 (42%)
ARM 3. /evidence=ECO:0000255 155..193 15/40 (38%)
ARM 4. /evidence=ECO:0000255 196..235 21/38 (55%)
ARM 5. /evidence=ECO:0000255 237..280 19/42 (45%)
ARM 6. /evidence=ECO:0000255 281..314 19/32 (59%)
ARM 7. /evidence=ECO:0000255 315..354 17/40 (43%)
ARM 8. /evidence=ECO:0000255 359..402 19/42 (45%)
SAM_SARM1-like_repeat1 409..477 CDD:188900 35/67 (52%)
SAM_SARM1-like_repeat2 478..547 CDD:188901 23/68 (34%)
TIR 561..702 CDD:214587 92/141 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 704..724 2/6 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151907
Domainoid 1 1.000 162 1.000 Domainoid score I4005
eggNOG 1 0.900 - - E1_KOG3678
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H9015
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S3511
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D113262at33208
OrthoFinder 1 1.000 - - FOG0007036
OrthoInspector 1 1.000 - - oto88719
orthoMCL 1 0.900 - - OOG6_107086
Panther 1 1.100 - - LDO PTHR22998
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5128
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.700

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