DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7565 and SPINT1

DIOPT Version :9

Sequence 1:	NP_648171.1	Gene:	CG7565 / 38893	FlyBaseID:	FBgn0035833	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001373802.1	Gene:	SPINT1 / 6692	HGNCID:	11246	Length:	529	Species:	Homo sapiens

Alignment Length:	244	Identity:	58/244 - (23%)
Similarity:	93/244 - (38%)	Gaps:	72/244 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 DSNAKFT--TCDMETP-----------CPPPQQC----VPLQPNAVRG---VCTCPEGFVWN--K 283
            |:||..:  ...:|:|           |...|.|    |.|||:  ||   :..|   |:.|  .
Human    64 DTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPD--RGEDAIAAC---FLINCLY 123

  Fly   284 QRKCVMAAVP---YSSYLTSNEAGQQEAAASENSPEVSTPPLKAEQNKDIVVSVMSKEVRLPEQE 345
            ::..|....|   :.:|||...........::.......|  ||....|:.|.        |::.
Human   124 EQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIP--KAWAGIDLKVQ--------PQEP 178

  Fly   346 VTLAAFTVPDEQTSDTKYKYLWTLISQPKGPMNGTISDQSKSKVKLSNLSEGLYTFKVTVTGDNG 410
            :.|     .|.:.:|      |.|:   :|..:..:..:..::|:|..|.||.|.|::|||..:
Human   179 LVL-----KDVENTD------WRLL---RGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSD- 228

  Fly   411 TFGEATANVTV------------LPENRINQP----PQVIISPREQIIR 443
             ..|.||||||            |..|::.:.    |:....|.|||.:
Human   229 -HPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICK 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7565	NP_648171.1	MANEC	52..153	CDD:297649
		PKD	<454..518	CDD:214510
		PKD	527..615	CDD:214510
		PKD	716..805	CDD:238084
SPINT1	NP_001373802.1	MANEC	50..139	CDD:400058	19/79 (24%)
		Kunitz_BPTI	249..301	CDD:394972	7/28 (25%)
		LDLa	334..366	CDD:197566
		Kunitz_BPTI	391..442	CDD:394972
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930