Protein Alignment CG7565 and Kiaa0319

DIOPT Version :10

• Sequence 1: NP_648171.1
• Gene: CG7565 / 38893
• FlyBaseID: FBgn0035833
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001183952.1
• Gene: Kiaa0319 / 361244
• RGDID: 1307443
• Length: 1081
• Species: Rattus norvegicus
• Alignment Length: 1157
• Identity: 384/1157 - (33%)
• Similarity: 543/1157 - (46%)
• Gaps: 204/1157 - (17%)

  Fly     8 ICNLLLLATAMSSAYADVTTQNALLVGSKKHKETSPDNSVGGSISPNLVCHKMLR--HVFENATP 70
            :.:.|||..||:...:...::.          .|..|    ..|||||...:::|  |.|.
  Rat     7 VLSSLLLLAAMAGGSSQQCSEG----------RTYSD----AIISPNLESIRIMRVSHTFS---- 53

  Fly    71 RDEQQAGVFEEYKPPPDAVEPLEEEAYLWNCLQACCEKPRNGSSACNVVLVFKAKCYHIRCQSNE 135
                                       :.:|..|||:.|     :|::...|:..||.:.|...|
  Rat    54 ---------------------------VGDCTAACCDLP-----SCDLAWWFEGSCYLVNCMRPE 86

  Fly   136 ACLPKLR---------VRMPNEKVQMVLVNPLGDATWPQLLKAEAAKQNAEILPYDEAALNFWKQ 191
            .|.|:..         ||.|.::...:|  ..||....:...:.|...:.|.|..|
  Rat    87 NCEPRTTGPIRSYLTFVRRPVQRSGQLL--DYGDMMLGRGSPSGAWGDSLEDLRKD--------- 140

  Fly   192 PRRLSYLARN---QETPVYEDEDFPLADKRMNQMIFQP-DENDVLANEELGYY--------DSNA 244
               |.:|.::   :||..|.| |:    |.:.:.:.|| ::.|...:.|...:        |.||
  Rat   141 ---LPFLGKDGGPEETAEYSD-DY----KELERGLLQPSNQQDPRGSAEYPDWSLLPSSDGDFNA 197

  Fly   245 KFT-----------------TCDME----------TPCPPPQQCVPLQPNAVRGVCTCPEGFVWN 282
            ..|                 ..|.|          :|.|...:...:.|::|....| .||....
  Rat   198 SATGDNSAASTEKLQDLTPYPLDQEQLQSLNESTWSPTPRHSEMSSMWPSSVTASPT-EEGLEGE 261

  Fly   283 KQ------------RKCVM--------------AAVPYSSYLT----SNEAGQQEAAASENSPEV 317
            :.            :|..|              ..|..||..|    |.:.|.....||...|.:
  Rat   262 ETLQLQEQPNNSSGKKVPMPSHNPSPASLESSPTTVEKSSIFTVTPWSRDPGTPTFPASTVLPGL 326

  Fly   318 STP-----PLKAEQNKDIVVSVMSKEV-RLPEQEVTLAAFTVPDEQTSDTKYKYLWTLISQPKGP 376
            .:|     |..:...|.:.||.....| .||..|..|.| :|.....:||.|.|.|:|:|.|. .
  Rat   327 ISPSWPLSPTTSRTVKALAVSAGDNLVLTLPNGEAELKA-SVEPAPPADTAYTYEWSLMSHPV-D 389

  Fly   377 MNGTISDQSKSKVKLSNLSEGLYTFKVTVTGDNGTFGEATANVTVLPENRINQPPQVIISPREQI 441
            ..|.|..::|..:.||.||.|||.|:|.|:|:| .|||...||||:|..||||||..|:||:.|.
  Rat   390 FQGKIKQENKPTLHLSQLSVGLYAFRVAVSGEN-AFGEGYVNVTVMPAARINQPPVAIVSPQIQE 453

  Fly   442 IRQPTTNAILDGSTSTDDDKITNWHWEVISGPIGYQPVLPEVNTLQLDLTSPGNYTFKLTVTDSN 506
            :..|.|:|::|||.||||.:|.::|||.:.||...:..|.:...|:|....||||||:||:|||:
  Rat   454 LSLPLTSALIDGSQSTDDAEIVSYHWEEVDGPFLGEAFLDDSPLLRLSNLDPGNYTFRLTITDSD 518

  Fly   507 NVTNSTTATIAVLKETDYAPVANAGDAVILYLPNNNVTLNGTASSDDHEIVAWEWTKDASDEAKA 571
            ..||||||.:.:....||.||||||....:.||.|.:.|||..|||||:||.:||..|...|:|.
  Rat   519 GATNSTTAALIIRGSLDYPPVANAGPNQTITLPQNTIILNGNQSSDDHQIVLYEWFPDPGGESKE 583

  Fly   572 VDMQNTRTPYVQLSNLEEGMYTFVLKVTDGSGQSSTAKVHVFVKPPTNSPPVAEAGSNTTTSLPI 636
            :.||..:|||:.||.|:||.|||.|.|||.|||.|||.|.:.|:...|..|||.||.:.....|:
  Rat   584 MVMQGAQTPYLHLSELQEGEYTFQLMVTDSSGQQSTALVTLTVQAENNQAPVAVAGPDKELVFPV 648

  Fly   637 NWVLLNGSDSKDDIGIKSYLWKQLSGPNNAVILKSNSSIANATSLTLGLYEFELTVADENNNTAT 701
            ...:|:||.|.||.||..|.|:.:.||:...:...:.:||..|.|.:|.|.|.|||.|:...::|
  Rat   649 QSAMLDGSRSSDDHGIVCYRWEHIRGPSAVEMENVDKAIATVTGLQVGTYHFRLTVRDQQGLSST 713

  Fly   702 DTTWVKIVQERNAAPIANAGGDHTVTLPATAIYFNGSKSWDDLAVVKYLWTRDEHSLAAGVIVAD 766
            .|..|.:.:|.|:.|.|.|||.|.:.||..:|..:||:|.||..:|.|||.||..|.|||.|:..
  Rat   714 STLTVAVKKENNSPPRAQAGGRHVLMLPNNSITLDGSRSTDDRGIVSYLWIRDGQSPAAGDIIGS 778

  Fly   767 TDKEPVMILTNLVQGRYVFTLTVSDDQGLTSSDTVSVNVRRDPKLLNLVQMTLPMGISVLVQSEL 831
            :|....:.|||||:|.|.|.|.|:|.||.:.|||..|.|..|||...:|::.|.:|:..|.:.:.
  Rat   779 SDNGAALQLTNLVEGVYTFHLLVTDSQGASDSDTAIVEVLPDPKKDGMVELILQVGVEQLTEQQK 843

  Fly   832 DSVVQKLQLLLG--DENKIQVRELKYDLHTD-ATVLVFYVNDGQG-KALDGLQVERQLRTQLQKD 892
            :::|::|.:||.  |.:   |:.||...||| :||:||||..|.. |.|....|.|.|..:|.|:
  Rat   844 ETLVRQLAVLLNVLDSD---VKVLKIQAHTDVSTVIVFYVQSGSPFKVLRAADVARNLHKRLSKE 905

  Fly   893 ASILGAF----AVDIRTSVCQSDCSGHGSCNPITRACICEAFWMPS--AGYFFNNQEANCDWSIL 951
            .   |||    .:.|.|:.|...|||||.|:|||:.|||...||.:  ..|.::. |:||:||:.
  Rat   906 K---GAFLLFKVLRIDTAGCLLKCSGHGHCDPITKRCICSQLWMENLLQRYMWDG-ESNCEWSVF 966

  Fly   952 YVFVGVIVGCLLLSGVFWGIACACRQSKKPRLRQKVQKYSLIGNKDEEAA--------------- 1001
            ||....:...:|...|.|...|.||:.|:.::|:|. ||:::.|.||:..
  Rat   967 YVAALALTLTVLTGAVTWVCICCCRRRKRTKIRKKT-KYTILDNMDEQERMELRPKYGIKHRSTE 1030

  Fly  1002 -NYSRNTSLTESETDSDVLFETRTKSNGLGKHKSHNSHSHGHGSSGGSGSSG 1052
             |.|...|.:|.|:|.|.||.......|:.|           ||..||..||
  Rat  1031 HNSSLMVSESEFESDQDTLFSQERMERGVLK-----------GSLNGSARSG 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7565	NP_648171.1	MANEC	52..153	CDD:471454	23/111 (21%)
		myxo_dep_M36	<428..810	CDD:468355	175/381 (46%)
Kiaa0319	NP_001183952.1	MANEC	23..102	CDD:471454	23/128 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..160		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..216		8/47 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..298		9/70 (13%)
		myxo_dep_M36	<440..825	CDD:468355	177/384 (46%)
		Endocytosis signal	1004..1007		1/2 (50%)