DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7565 and E01G6.1

DIOPT Version :9

Sequence 1:	NP_648171.1	Gene:	CG7565 / 38893	FlyBaseID:	FBgn0035833	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_510044.2	Gene:	E01G6.1 / 181387	WormBaseID:	WBGene00008449	Length:	1467	Species:	Caenorhabditis elegans

Alignment Length:	481	Identity:	88/481 - (18%)
Similarity:	142/481 - (29%)	Gaps:	172/481 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TTQNALLVGSKKHKETSP--DNSVGGSISPNLVCHKMLRHVFENATPRDEQQAGVFEEYKPPPDA 88
            :||.::....|..|:.|.  .|..||  :||       |...:.|......|:..|...   |..
Worm   555 STQRSMWFYDKSKKKCSQFVYNGCGG--TPN-------RFTTKVACTESCVQSSAFGLC---PRG 607

  Fly    89 VEPLEEEAYL------WNCLQAC-----CEKPRNGSSACNVVLVFKAKCYHIRCQSNEACLPKLR 142
            :.|..||..:      .|....|     |.|.....|.|              |::..||
Worm   608 MNPFTEEGEITPKTCTLNVRSTCPSGASCVKSSTNQSIC--------------CKAVTAC----- 653

  Fly   143 VRMPNEKVQMVLVNPLGDATWPQLLKAEAAKQNAEILPYDEAALNFWKQPRRLSYLARNQETPVY 207
               |:.::...:         |......|.....:..|.|...|.....|.  .::..:...|..
Worm   654 ---PDNRIPYNI---------PGTNSVVACSIERDDCPDDFQCLESATAPG--FHMCCSGPLPSA 704

  Fly   208 EDEDFPLAD-KRMNQMIFQPDE-NDVLANEELGYYDSNAKFTTCDMETPCPPP-----QQCVPLQ 265
            :....|:|. ..|.:..|:||. .|:|:|                 .:||||.     |.|
Worm   705 QRPVRPIAPVAPMPRRPFEPDSFADLLSN-----------------ISPCPPQLFSSGQSC---- 748

  Fly   266 PNAVRGVCTCPE--------GFVWNKQRKCVMAAVPYSSYLTSNEAGQQEAAASENSPEVSTPPL 322
              .|..|..||:        ||   ||..|..                            :|||
Worm   749 --TVNQVGDCPKNHICFRDIGF---KQGSCCR----------------------------TTPP- 779

  Fly   323 KAEQNKDIVVSVMSKEVRLPEQEVTLAAFTVPDEQTSDTK-------------YKYLWTLISQPK 374
            |..|...:.|.:...:|::.:.::        |....|.|             .||      ||.
Worm   780 KCSQRGYVPVFLDRTQVQVCQVDL--------DGCPEDAKCMTSSVAKLAICCQKY------QPP 830

  Fly   375 GPMN----------GTISDQSKSKVKLSNLSEGLYTFKVTVTGDNGTFGEATANVTVLPEN---R 426
            .|.|          |::|:.:::..|.:..:.|...|:    |.:..|.|........|..   .
Worm   831 SPNNNRPANRGVNQGSVSNNNQNNNKGAVCANGETPFR----GPDNKFQECNFVHNTCPSGYQCE 891

  Fly   427 INQPPQVIISPREQIIRQPTTNAILD 452
            .:...|.:......:||.|:.:::.:
Worm   892 FSSTGQAVCCTNTNVIRCPSGSSVFE 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7565	NP_648171.1	MANEC	52..153	CDD:297649	20/111 (18%)
		PKD	<454..518	CDD:214510
		PKD	527..615	CDD:214510
		PKD	716..805	CDD:238084
E01G6.1	NP_510044.2	Lustrin_cystein	95..136	CDD:291299
		WR1	289..325	CDD:214601
		Kunitz_BPTI	330..386	CDD:278443
		Kunitz_BPTI	437..492	CDD:278443
		Kunitz_BPTI	541..596	CDD:278443	12/49 (24%)
		Lustrin_cystein	860..902	CDD:291299	7/45 (16%)
		Lustrin_cystein	909..951	CDD:291299	1/9 (11%)
		Lustrin_cystein	963..1006	CDD:291299
		EB	1265..1321	CDD:279949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930