DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7565 and WFIKKN2

DIOPT Version :9

Sequence 1:	NP_648171.1	Gene:	CG7565 / 38893	FlyBaseID:	FBgn0035833	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_783165.1	Gene:	WFIKKN2 / 124857	HGNCID:	30916	Length:	576	Species:	Homo sapiens

Alignment Length:	266	Identity:	54/266 - (20%)
Similarity:	89/266 - (33%)	Gaps:	82/266 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 EAYLWNCLQAC-----CEKPRNGSSACNVVLVFKAKCYHIRCQSNEACLPKLRVRMPNEKVQMVL 154
            |..:|:....|     |||..:.:.|.: .|.:..:||    ...|||         ::.:.:.:
Human   122 ECDIWDGQPVCKCKDRCEKEPSFTCASD-GLTYYNRCY----MDAEAC---------SKGITLAV 172

  Fly   155 VNPLGDATWPQLLKAEAAKQNAEILPYDEAALNFWKQPRRLSYLARNQETPVYEDEDFPLADKRM 219
            |......|||....           |..|..::                 |.....:.|..|...
Human   173 VTCRYHFTWPNTSP-----------PPPETTMH-----------------PTTASPETPELDMAA 209

  Fly   220 NQMIFQPDENDVLANEELGYYDSNAKFTTCDMETPCPPPQ----------QCVPLQPNAVRG--- 271
            ..::..|....|...|.:.:        .||: ...|.|:          :.|.::||.|||
Human   210 PALLNNPVHQSVTMGETVSF--------LCDV-VGRPRPEITWEKQLEDRENVVMRPNHVRGNVV 265

  Fly   272 VCTCPEGFVWNKQRK------CV---MAAVPYSSYLTSNEAGQQEAAASENSPEVSTPP----LK 323
            |....:..::|.|.:      |.   :|.|..:.:..|...|.|.||.||:||..:..|    ||
Human   266 VTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLSVVRGHQAAATSESSPNGTAFPAAECLK 330

  Fly   324 AEQNKD 329
            ...::|
Human   331 PPDSED 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7565	NP_648171.1	MANEC	52..153	CDD:297649	13/62 (21%)
		PKD	<454..518	CDD:214510
		PKD	527..615	CDD:214510
		PKD	716..805	CDD:238084
WFIKKN2	NP_783165.1	WAP	44..90	CDD:278522
		KAZAL_FS	138..174	CDD:238052	10/49 (20%)
		I-set	216..304	CDD:254352	19/96 (20%)
		Ig_3	224..304	CDD:143242	17/88 (19%)
		Kunitz_BPTI	328..379	CDD:278443	3/9 (33%)
		Kunitz_BPTI	385..436	CDD:278443
		NTR_WFIKKN	455..563	CDD:239630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930