DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7565 and kiaa0319l

DIOPT Version :9

Sequence 1:	NP_648171.1	Gene:	CG7565 / 38893	FlyBaseID:	FBgn0035833	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_005159827.1	Gene:	kiaa0319l / 100034533	ZFINID:	ZDB-GENE-060503-110	Length:	951	Species:	Danio rerio

Alignment Length:	994	Identity:	332/994 - (33%)
Similarity:	503/994 - (50%)	Gaps:	160/994 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EPLEEEAYLWNCLQACCEKPRNGSSACNVVLVFKAKCYHIRCQSNEACLPKLRVRMPNEKVQMVL 154
            :||..:.....|.::||.:|     :|..|.....:|..:.|...|.|
Zfish    59 QPLAVDQGGSRCWESCCLEP-----SCGAVWSLGGRCVLLACSQRETC----------------- 101

  Fly   155 VNPLGDATWPQLLKAEAAKQNAEILPYDEA-----ALNFWKQPRRLSYLARNQETPVYEDEDFPL 214
                |.::.||              |:.|:     .||  |..||.:..|  |:.....|.:
Zfish   102 ----GISSLPQ--------------PHVESLGLLQLLN--KSKRRKTRSA--QDIRAIRDTE--- 141

  Fly   215 ADKRMNQMIFQPDE-----NDVLANEELGYYDSNAKF-TTCDMETPCPPPQQCVPLQPNAVRGVC 273
                 ..|...|.|     |...::...|  :..|:. ||.|.:
Zfish   142 -----QDMSSNPSEPLTTSNSAASSSSSG--EQTAEHNTTLDSD--------------------- 178

  Fly   274 TCPEGFVWNKQRKCVMAAVPYSSYLTSNEAGQQEAAASENSPEVSTPPLKAEQNKDIVVSV-MSK 337
                             |..:|:...||::.|...|.:      :||.:..   :::|||. .:.
Zfish   179 -----------------AANHSTLNNSNQSPQSTVAPA------TTPAVTV---RELVVSAGQNV 217

  Fly   338 EVRLPEQEVTLAAFTVPDEQTSDTKYKYLWTLISQPKGPMNGTISDQSKSKVKLSNLSEGLYTFK 402
            ||.||..||.|:|:.||...|. |.|.:.|.||:.|| ..:|.:..:....:|||.|:.|||.|:
Zfish   218 EVTLPRNEVKLSAYVVPAPPTG-TNYDFDWRLITHPK-DYSGEMEGKHTMTLKLSKLTVGLYEFE 280

  Fly   403 VTVTGDNGTFGEATANVTVLPENRINQPPQVIISPREQIIRQPTTNAILDGSTSTDDDKITNWHW 467
            |.|.|: |..||...||||.||.|:|:||..::||:.|.|..||::.::|||.||||||:..|||
Zfish   281 VVVDGE-GAHGEGYVNVTVKPEPRVNKPPVAVVSPKYQEISLPTSSTVIDGSRSTDDDKVVLWHW 344

  Fly   468 EVISGPIGYQPVLPEVNTLQLDLTSPGNYTFKLTVTDSNNVTNSTTATIAVLKETDYAPVANAGD 532
            |.:.||:..:....:.:.|.|....||||||.||||||:...|||.|.:.|.|.|||.|.||||.
Zfish   345 EEVKGPLREEKASGDTDILTLTNLVPGNYTFSLTVTDSDGAQNSTQAMLLVNKATDYRPTANAGP 409

  Fly   533 AVILYLPNNNVTLNGTASSDDHEIVAWEWTKDASDEAKAVDMQNTRTPYVQLSNLEEGMYTFVLK 597
            ..::.||:|.:||||..|:|||:.:::||:.....:.|.|:||..|||.:|||.::||.|||.|.
Zfish   410 NQVITLPHNYITLNGNQSTDDHDNLSYEWSLSPESKGKVVEMQGVRTPTLQLSAMQEGDYTFELT 474

  Fly   598 VTDGSGQSSTAKVHVFVKPPTNSPPVAEAGSNTTTSLPINWVLLNGSDSKDDIGIKSYLWKQLSG 662
            |||.|||..|.:|.|.|:|..|.||||:||.:...:||::...|:|..|.||..|.:|.||:..|
Zfish   475 VTDSSGQQDTTQVTVIVQPENNQPPVADAGPDKELTLPVDHTTLDGGKSTDDQKIVTYHWKKTKG 539

  Fly   663 PNNAVILKSNSSIANATSLTLGLYEFELTVADENNNTATDTTWVKIVQERNAAPIANAGGDHTVT 727
            |....:..:.:.:|..|.|..|.|.|.|||.||.|..::||..|.:.:|.:..|:|.......:|
Zfish   540 PEGVKLDNAETVVATVTGLQEGEYIFMLTVTDERNLESSDTVSVIVREENDQPPVAKVVSSPPIT 604

  Fly   728 LPATAIYFNGSKSWDDLAVVKYLWTRDEHSLAAGVIVADTDKEPVMILTNLVQGRYVFTLTVSDD 792
            ||......:||:|.||...:.|||||:|:|.|||.::..:|.:.|:.|.|||:|:|.|||||:|.
Zfish   605 LPVRTAVLDGSRSSDDKGSISYLWTREENSPAAGDVLNHSDHQAVLFLGNLVEGKYSFTLTVTDS 669

  Fly   793 QGLTSSDTVSVNVRRDPKLLNLVQMTLPMGISVLVQSELDSVVQKLQLLLGD-ENKIQVRELK-Y 855
            :|.||||:..|:||.|....:||::.|.:.::.:.:.:.|..::::.:|||. ::.|.:||:. :
Zfish   670 KGKTSSDSGVVDVRPDVYERDLVELILEVAVAQVSRRQKDMYIRQVGVLLGVLDSDITIREISAF 734

  Fly   856 DLHTDATVLVFYVNDGQGK-ALDGLQVERQLRTQLQKDAS---ILGAFAVDIRTSVCQSDCSGHG 916
            :.|  :|.|||.|:.|.|: .|.|..|..:||.:.:|..:   |..|..||  |.:||.:|||||
Zfish   735 NEH--STRLVFLVSGGPGRPPLTGHSVAMELRNKFRKQKNEFLIFKARRVD--TVICQLNCSGHG 795

  Fly   917 SCNPITRACICEAFWMPSA-GYFFNNQEANCDWSILYVFVGVIVGCLLLSGVFWGIACACRQSKK 980
            .|:..||.|:|..|||.:. ..:|.:.|:||:||:|||.:...:..:.::.|.||:.|.||: :|
Zfish   796 ECDSFTRRCVCHLFWMENLFSTYFGDAESNCEWSVLYVTIASFMIVVAIATVIWGLVCCCRR-RK 859

  Fly   981 PRLRQKVQKYSLIGNKDEEAANYS-------------RNTSLTESETD--SD-----VLFETRTK 1025
            .::|:| .:|.::...|:|.....             .:::|..|::|  ||     :.:..|.:
Zfish   860 SKVRRK-SRYKMLNEDDQETMELKLPRPGRLKSVPAPTSSALMHSDSDLESDDGQAGIPWSDRER 923

  Fly  1026 S-----------NGLGKHK 1033
            .           ||.|.||
Zfish   924 GKLLPPQNGSLRNGQGPHK 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7565	NP_648171.1	MANEC	52..153	CDD:297649	12/62 (19%)
		PKD	<454..518	CDD:214510	31/63 (49%)
		PKD	527..615	CDD:214510	42/87 (48%)
		PKD	716..805	CDD:238084	40/88 (45%)
kiaa0319l	XP_005159827.1	PKD	309..395	CDD:214510	39/85 (46%)
		PKD	403..491	CDD:238084	43/87 (49%)
		PKD	<523..585	CDD:238084	24/61 (39%)
		PKD	594..682	CDD:214510	39/87 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575825
Domainoid	1	1.000	512	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_28IWW
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1275
OMA	1	1.010	-	-		QHG47042
OrthoDB	1	1.010	-	-		D224617at33208
OrthoFinder	1	1.000	-	-		FOG0004787
OrthoInspector	1	1.000	-	-		otm25069
orthoMCL	1	0.900	-	-		OOG6_105545
Panther	1	1.100	-	-	LDO	PTHR46182
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4968
SonicParanoid	1	1.000	-	-		X2843
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800