DRSC/TRiP Functional Genomics Resources

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Protein Alignment nmo and Cilk1

DIOPT Version :9

Sequence 1:NP_001356976.1 Gene:nmo / 38890 FlyBaseID:FBgn0011817 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_001157252.1 Gene:Cilk1 / 56542 MGIID:1934157 Length:629 Species:Mus musculus


Alignment Length:397 Identity:115/397 - (28%)
Similarity:184/397 - (46%) Gaps:50/397 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 RPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDIL-Q 107
            :.:|.|.:|.|........|..:|:||:...|.|......: ||:|.|....|.|::...::: :
Mouse     8 KQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNL-REVKSLKKLNHANIVKLKEVIRE 71

  Fly   108 PPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADH-IKVFLYQILRGLKYLHSARILHRDIKPGN 171
            ..||      |.|.|.::.:|:::|.....|..:. |:..:||||:||.::|.....|||:||.|
Mouse    72 NDHL------YFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130

  Fly   172 LLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGEL 236
            ||.....::||.||||||  |.......|..|.|::|||||:|:.:.:|||.:|:|:||||..|:
Mouse   131 LLCMGPELVKIADFGLAR--EIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEV 193

  Fly   237 LGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSF-SVLYTLSSHATH 300
            ...|.||...:.:..:..|.::||||...|..   ||.:.........|... :.|.||..:|:.
Mouse   194 YTLRPLFPGASEIDTIFKICQVLGTPKKTDWP---EGYQLSSAMNFLWPQCIPNNLKTLIPNASS 255

  Fly   301 EAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAGQP 365
            ||:.||..:|.:||.||.:.:.||.:||...|.              ..|:      ....:|:|
Mouse   256 EAIQLLRDLLQWDPKKRPTASQALRYPYFQIGH--------------PLGI------ISKDSGKP 300

  Fly   366 FDDLWER-------KLTSVQQVKEEMHKFIAEQLQTGRVPLCINPQSAA--FKSFASST--VAHP 419
            ..::.::       |.....|...:.:..|:.:......|    ||.:.  :|...|.|  ::|.
Mouse   301 QREVQDKTGPPPYIKPAPPAQAPAKAYTLISSRPSQASQP----PQHSVHPYKGDVSRTEQLSHV 361

  Fly   420 SELPPSP 426
            .|..|||
Mouse   362 QEGKPSP 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nmoNP_001356976.1 STKc_NLK 39..411 CDD:173748 108/378 (29%)
Cilk1NP_001157252.1 STKc_MAK_like 4..284 CDD:270824 96/287 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..376 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..483
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 581..629
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833240
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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